Inhibition of Ceramide Glycosylation Enhances Cisplatin Sensitivity in Cholangiocarcinoma by Limiting the Activation of the ERK Signaling Pathway

Inhibition of Ceramide Glycosylation Enhances Cisplatin Sensitivity in Cholangiocarcinoma by Limiting the Activation of the ERK Signaling Pathway

Cholangiocarcinoma (CCA) is an aggressive tumor of the biliary epithelium with poor survival that shows limited response to conventional chemotherapy. Increased expression of glucosylceramide synthase (GCS) contributes to drug resistance and the progression of various cancers; the expression profile...

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Bibliographic Details
Main Authors: Piyasiri Chueakwon, Peeranat Jatooratthawichot, Krajang Talabnin, James R. Ketudat Cairns, Chutima Talabnin
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Life
Subjects:
glucosylceramide synthase
PPMP
cisplatin
sensitivity
cholangiocarcinoma
Online Access:https://www.mdpi.com/2075-1729/12/3/351

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