Outcomes of cystoid macular edema following Descemet’s membrane endothelial keratoplasty in a referral center for keratoplasty in Spain: retrospective study
Abstract The aim of this study was to analyze the outcomes of eyes with visually significant cystoid macular œdema (vs-CMO) after Descemet membrane endothelial keratoplasty (DMEK) in a referral center for keratoplasty in Spain. We conducted a retrospective, single-surgeon case series of eyes that de...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-02-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-29127-5 |
| _version_ | 1811165931300192256 |
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| author | Nuno Moura-Coelho Renato Papa-Vettorazzi Imalvet Santiesteban-García Arnaldo Dias-Santos Felicidad Manero João Paulo Cunha José Güell |
| author_facet | Nuno Moura-Coelho Renato Papa-Vettorazzi Imalvet Santiesteban-García Arnaldo Dias-Santos Felicidad Manero João Paulo Cunha José Güell |
| author_sort | Nuno Moura-Coelho |
| collection | DOAJ |
| description | Abstract The aim of this study was to analyze the outcomes of eyes with visually significant cystoid macular œdema (vs-CMO) after Descemet membrane endothelial keratoplasty (DMEK) in a referral center for keratoplasty in Spain. We conducted a retrospective, single-surgeon case series of eyes that developed post-DMEK vs-CMO performed between January 2011 and December 2020. Data collected included: indication for DMEK; biometric data; ocular comorbidities; past medical history; time to detection of vs-CMO after DMEK (T, weeks); best-corrected visual acuity (BCVA, logMAR) and central retinal thickness (CRT, µm) at diagnosis of vs-CMO, after resolution of CMO, and at last follow-up; and management strategy. Main outcomes analyzed were incidence of vs-CMO, improvement in BCVA and CRT after treatment of vs-CMO. Of 291 consecutive DMEK surgeries, 14 eyes of 13 patients (4.8%) developed vs-CMO. Five patients (38.5%) had history of CMO, and 28.6% of eyes had ophthalmic comorbidities. Median (P25-P75) T was 4 (3–10) weeks. Treatment success was observed in 12/13 eyes (92.3%), two of which required second-line treatment. In successful cases (median time-to-resolution 3.0 (2.0–3.5) months), median BCVA improved from 0.60 (0.40–0.80) logMAR to 0.30 (0.15–0.40) logMAR (p = 0.002) after treatment, and median CRT improved from 582.5 (400.0–655.0) µm to 278.0 (258.0–294.0) µm (p = 0.005). In our study, we found a 4.8% rate of post-DMEK vs-CMO, with most cases occurring in the first 3 months after surgery. Good functional and anatomical outcomes are expected in most eyes, without treatment-related complications or implications in graft outcomes. Additional studies are encouraged to determine a standardized protocol for post-DMEK vs-CMO. |
| first_indexed | 2024-04-10T15:44:14Z |
| format | Article |
| id | doaj.art-75fb2d1449904c5ea30422c0e1aa9395 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-10T15:44:14Z |
| publishDate | 2023-02-01 |
| publisher | Nature Portfolio |
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| spelling | doaj.art-75fb2d1449904c5ea30422c0e1aa93952023-02-12T12:12:33ZengNature PortfolioScientific Reports2045-23222023-02-011311910.1038/s41598-023-29127-5Outcomes of cystoid macular edema following Descemet’s membrane endothelial keratoplasty in a referral center for keratoplasty in Spain: retrospective studyNuno Moura-Coelho0Renato Papa-Vettorazzi1Imalvet Santiesteban-García2Arnaldo Dias-Santos3Felicidad Manero4João Paulo Cunha5José Güell6Cornea and Refractive Surgery Unit, Instituto Microcirurgia Ocular (IMO)Cornea and Refractive Surgery Unit, Instituto Microcirurgia Ocular (IMO)Cornea and Refractive Surgery Unit, Instituto Microcirurgia Ocular (IMO)NOVA Medical School, Faculdade de Ciências Médicas – Universidade Nova de Lisboa (NMS|FCM-UNL)Cornea and Refractive Surgery Unit, Instituto Microcirurgia Ocular (IMO)Ophthalmology, Hospital CUF CascaisCornea and Refractive Surgery Unit, Instituto Microcirurgia Ocular (IMO)Abstract The aim of this study was to analyze the outcomes of eyes with visually significant cystoid macular œdema (vs-CMO) after Descemet membrane endothelial keratoplasty (DMEK) in a referral center for keratoplasty in Spain. We conducted a retrospective, single-surgeon case series of eyes that developed post-DMEK vs-CMO performed between January 2011 and December 2020. Data collected included: indication for DMEK; biometric data; ocular comorbidities; past medical history; time to detection of vs-CMO after DMEK (T, weeks); best-corrected visual acuity (BCVA, logMAR) and central retinal thickness (CRT, µm) at diagnosis of vs-CMO, after resolution of CMO, and at last follow-up; and management strategy. Main outcomes analyzed were incidence of vs-CMO, improvement in BCVA and CRT after treatment of vs-CMO. Of 291 consecutive DMEK surgeries, 14 eyes of 13 patients (4.8%) developed vs-CMO. Five patients (38.5%) had history of CMO, and 28.6% of eyes had ophthalmic comorbidities. Median (P25-P75) T was 4 (3–10) weeks. Treatment success was observed in 12/13 eyes (92.3%), two of which required second-line treatment. In successful cases (median time-to-resolution 3.0 (2.0–3.5) months), median BCVA improved from 0.60 (0.40–0.80) logMAR to 0.30 (0.15–0.40) logMAR (p = 0.002) after treatment, and median CRT improved from 582.5 (400.0–655.0) µm to 278.0 (258.0–294.0) µm (p = 0.005). In our study, we found a 4.8% rate of post-DMEK vs-CMO, with most cases occurring in the first 3 months after surgery. Good functional and anatomical outcomes are expected in most eyes, without treatment-related complications or implications in graft outcomes. Additional studies are encouraged to determine a standardized protocol for post-DMEK vs-CMO.https://doi.org/10.1038/s41598-023-29127-5 |
| spellingShingle | Nuno Moura-Coelho Renato Papa-Vettorazzi Imalvet Santiesteban-García Arnaldo Dias-Santos Felicidad Manero João Paulo Cunha José Güell Outcomes of cystoid macular edema following Descemet’s membrane endothelial keratoplasty in a referral center for keratoplasty in Spain: retrospective study Scientific Reports |
| title | Outcomes of cystoid macular edema following Descemet’s membrane endothelial keratoplasty in a referral center for keratoplasty in Spain: retrospective study |
| title_full | Outcomes of cystoid macular edema following Descemet’s membrane endothelial keratoplasty in a referral center for keratoplasty in Spain: retrospective study |
| title_fullStr | Outcomes of cystoid macular edema following Descemet’s membrane endothelial keratoplasty in a referral center for keratoplasty in Spain: retrospective study |
| title_full_unstemmed | Outcomes of cystoid macular edema following Descemet’s membrane endothelial keratoplasty in a referral center for keratoplasty in Spain: retrospective study |
| title_short | Outcomes of cystoid macular edema following Descemet’s membrane endothelial keratoplasty in a referral center for keratoplasty in Spain: retrospective study |
| title_sort | outcomes of cystoid macular edema following descemet s membrane endothelial keratoplasty in a referral center for keratoplasty in spain retrospective study |
| url | https://doi.org/10.1038/s41598-023-29127-5 |
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