Emerging Therapeutic RNAs for the Targeting of Cancer Associated Fibroblasts
Tumor mass consists of a complex ensemble of malignant cancer cells and a wide variety of resident and infiltrating cells, secreted factors, and extracellular matrix proteins that are referred as tumor microenvironment (TME). Cancer associated fibroblasts (CAFs) are key TME components that support t...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-05-01
|
| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/12/6/1365 |
| _version_ | 1797566953681846272 |
|---|---|
| author | Laura Santana-Viera Maria L. Ibba Deborah Rotoli Silvia Catuogno Carla L. Esposito |
| author_facet | Laura Santana-Viera Maria L. Ibba Deborah Rotoli Silvia Catuogno Carla L. Esposito |
| author_sort | Laura Santana-Viera |
| collection | DOAJ |
| description | Tumor mass consists of a complex ensemble of malignant cancer cells and a wide variety of resident and infiltrating cells, secreted factors, and extracellular matrix proteins that are referred as tumor microenvironment (TME). Cancer associated fibroblasts (CAFs) are key TME components that support tumor growth, generating a physical barrier against drugs and immune infiltration, and contributing to regulate malignant progression. Thus, it is largely accepted that therapeutic approaches aimed at hampering the interactions between tumor cells and CAFs can enhance the effectiveness of anti-cancer treatments. In this view, nucleic acid therapeutics have emerged as promising molecules. Here, we summarize recent knowledge about their role in the regulation of CAF transformation and tumor-promoting functions, highlighting their therapeutic utility and challenges. |
| first_indexed | 2024-03-10T19:34:46Z |
| format | Article |
| id | doaj.art-75fbc9a0e9294730a420390131cc30e2 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T19:34:46Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-75fbc9a0e9294730a420390131cc30e22023-11-20T01:50:07ZengMDPI AGCancers2072-66942020-05-01126136510.3390/cancers12061365Emerging Therapeutic RNAs for the Targeting of Cancer Associated FibroblastsLaura Santana-Viera0Maria L. Ibba1Deborah Rotoli2Silvia Catuogno3Carla L. Esposito4Institute Experimental Endocrinology and Oncology “Gaetano Salvatore” (IEOS), National Research Council (CNR), 80145 Naples, ItalyInstitute Experimental Endocrinology and Oncology “Gaetano Salvatore” (IEOS), National Research Council (CNR), 80145 Naples, ItalyInstitute Experimental Endocrinology and Oncology “Gaetano Salvatore” (IEOS), National Research Council (CNR), 80145 Naples, ItalyInstitute Experimental Endocrinology and Oncology “Gaetano Salvatore” (IEOS), National Research Council (CNR), 80145 Naples, ItalyInstitute Experimental Endocrinology and Oncology “Gaetano Salvatore” (IEOS), National Research Council (CNR), 80145 Naples, ItalyTumor mass consists of a complex ensemble of malignant cancer cells and a wide variety of resident and infiltrating cells, secreted factors, and extracellular matrix proteins that are referred as tumor microenvironment (TME). Cancer associated fibroblasts (CAFs) are key TME components that support tumor growth, generating a physical barrier against drugs and immune infiltration, and contributing to regulate malignant progression. Thus, it is largely accepted that therapeutic approaches aimed at hampering the interactions between tumor cells and CAFs can enhance the effectiveness of anti-cancer treatments. In this view, nucleic acid therapeutics have emerged as promising molecules. Here, we summarize recent knowledge about their role in the regulation of CAF transformation and tumor-promoting functions, highlighting their therapeutic utility and challenges.https://www.mdpi.com/2072-6694/12/6/1365tumor microenvironmentcancer associated fibroblaststherapeutic RNAs |
| spellingShingle | Laura Santana-Viera Maria L. Ibba Deborah Rotoli Silvia Catuogno Carla L. Esposito Emerging Therapeutic RNAs for the Targeting of Cancer Associated Fibroblasts Cancers tumor microenvironment cancer associated fibroblasts therapeutic RNAs |
| title | Emerging Therapeutic RNAs for the Targeting of Cancer Associated Fibroblasts |
| title_full | Emerging Therapeutic RNAs for the Targeting of Cancer Associated Fibroblasts |
| title_fullStr | Emerging Therapeutic RNAs for the Targeting of Cancer Associated Fibroblasts |
| title_full_unstemmed | Emerging Therapeutic RNAs for the Targeting of Cancer Associated Fibroblasts |
| title_short | Emerging Therapeutic RNAs for the Targeting of Cancer Associated Fibroblasts |
| title_sort | emerging therapeutic rnas for the targeting of cancer associated fibroblasts |
| topic | tumor microenvironment cancer associated fibroblasts therapeutic RNAs |
| url | https://www.mdpi.com/2072-6694/12/6/1365 |
| work_keys_str_mv | AT laurasantanaviera emergingtherapeuticrnasforthetargetingofcancerassociatedfibroblasts AT marialibba emergingtherapeuticrnasforthetargetingofcancerassociatedfibroblasts AT deborahrotoli emergingtherapeuticrnasforthetargetingofcancerassociatedfibroblasts AT silviacatuogno emergingtherapeuticrnasforthetargetingofcancerassociatedfibroblasts AT carlalesposito emergingtherapeuticrnasforthetargetingofcancerassociatedfibroblasts |