Harnessing a high cargo-capacity transposon for genetic applications in vertebrates.

Harnessing a high cargo-capacity transposon for genetic applications in vertebrates.

Viruses and transposons are efficient tools for permanently delivering foreign DNA into vertebrate genomes but exhibit diminished activity when cargo exceeds 8 kilobases (kb). This size restriction limits their molecular genetic and biotechnological utility, such as numerous therapeutically relevant...

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Bibliographic Details
Main Authors: Darius Balciunas, Kirk J Wangensteen, Andrew Wilber, Jason Bell, Aron Geurts, Sridhar Sivasubbu, Xin Wang, Perry B Hackett, David A Largaespada, R Scott McIvor, Stephen C Ekker
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2006-11-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC1635535?pdf=render

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