RNA-Binding Proteins in Cardiomyopathies
The post-transcriptional regulation of gene expression plays an important role in heart development and disease. Cardiac-specific alternative splicing, mediated by RNA-binding proteins, orchestrates the isoform switching of proteins that are essential for cardiomyocyte organization and contraction....
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-03-01
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| Series: | Journal of Cardiovascular Development and Disease |
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| Online Access: | https://www.mdpi.com/2308-3425/11/3/88 |
| _version_ | 1797240553244459008 |
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| author | De-Li Shi |
| author_facet | De-Li Shi |
| author_sort | De-Li Shi |
| collection | DOAJ |
| description | The post-transcriptional regulation of gene expression plays an important role in heart development and disease. Cardiac-specific alternative splicing, mediated by RNA-binding proteins, orchestrates the isoform switching of proteins that are essential for cardiomyocyte organization and contraction. Dysfunctions of RNA-binding proteins impair heart development and cause the main types of cardiomyopathies, which represent a heterogenous group of abnormalities that severely affect heart structure and function. In particular, mutations of RBM20 and RBFOX2 are associated with dilated cardiomyopathy, hypertrophic cardiomyopathy, or hypoplastic left heart syndrome. Functional analyses in different animal models also suggest possible roles for other RNA-binding proteins in cardiomyopathies because of their involvement in organizing cardiac gene programming. Recent studies have provided significant insights into the causal relationship between RNA-binding proteins and cardiovascular diseases. They also show the potential of correcting pathogenic mutations in RNA-binding proteins to rescue cardiomyopathy or promote cardiac regeneration. Therefore, RNA-binding proteins have emerged as promising targets for therapeutic interventions for cardiovascular dysfunction. The challenge remains to decipher how they coordinately regulate the temporal and spatial expression of target genes to ensure heart function and homeostasis. This review discusses recent advances in understanding the implications of several well-characterized RNA-binding proteins in cardiomyopathies, with the aim of identifying research gaps to promote further investigation in this field. |
| first_indexed | 2024-04-24T18:09:16Z |
| format | Article |
| id | doaj.art-75fbee221de6478995793f2c3e6d059c |
| institution | Directory Open Access Journal |
| issn | 2308-3425 |
| language | English |
| last_indexed | 2024-04-24T18:09:16Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Cardiovascular Development and Disease |
| spelling | doaj.art-75fbee221de6478995793f2c3e6d059c2024-03-27T13:47:34ZengMDPI AGJournal of Cardiovascular Development and Disease2308-34252024-03-011138810.3390/jcdd11030088RNA-Binding Proteins in CardiomyopathiesDe-Li Shi0Department of Medical Research, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, ChinaThe post-transcriptional regulation of gene expression plays an important role in heart development and disease. Cardiac-specific alternative splicing, mediated by RNA-binding proteins, orchestrates the isoform switching of proteins that are essential for cardiomyocyte organization and contraction. Dysfunctions of RNA-binding proteins impair heart development and cause the main types of cardiomyopathies, which represent a heterogenous group of abnormalities that severely affect heart structure and function. In particular, mutations of RBM20 and RBFOX2 are associated with dilated cardiomyopathy, hypertrophic cardiomyopathy, or hypoplastic left heart syndrome. Functional analyses in different animal models also suggest possible roles for other RNA-binding proteins in cardiomyopathies because of their involvement in organizing cardiac gene programming. Recent studies have provided significant insights into the causal relationship between RNA-binding proteins and cardiovascular diseases. They also show the potential of correcting pathogenic mutations in RNA-binding proteins to rescue cardiomyopathy or promote cardiac regeneration. Therefore, RNA-binding proteins have emerged as promising targets for therapeutic interventions for cardiovascular dysfunction. The challenge remains to decipher how they coordinately regulate the temporal and spatial expression of target genes to ensure heart function and homeostasis. This review discusses recent advances in understanding the implications of several well-characterized RNA-binding proteins in cardiomyopathies, with the aim of identifying research gaps to promote further investigation in this field.https://www.mdpi.com/2308-3425/11/3/88cardiomyopathyRNA-binding proteinpost-transcriptional regulationRBM20RBM24RBPMS |
| spellingShingle | De-Li Shi RNA-Binding Proteins in Cardiomyopathies Journal of Cardiovascular Development and Disease cardiomyopathy RNA-binding protein post-transcriptional regulation RBM20 RBM24 RBPMS |
| title | RNA-Binding Proteins in Cardiomyopathies |
| title_full | RNA-Binding Proteins in Cardiomyopathies |
| title_fullStr | RNA-Binding Proteins in Cardiomyopathies |
| title_full_unstemmed | RNA-Binding Proteins in Cardiomyopathies |
| title_short | RNA-Binding Proteins in Cardiomyopathies |
| title_sort | rna binding proteins in cardiomyopathies |
| topic | cardiomyopathy RNA-binding protein post-transcriptional regulation RBM20 RBM24 RBPMS |
| url | https://www.mdpi.com/2308-3425/11/3/88 |
| work_keys_str_mv | AT delishi rnabindingproteinsincardiomyopathies |