The Biological Activities of Sesterterpenoid-Type Ophiobolins
Ophiobolins (Ophs) are a group of tricarbocyclic sesterterpenoids whose structures contain a tricyclic 5-8-5 carbotricyclic skeleton. Thus far, 49 natural Ophs have been reported and assigned into A–W subgroups in order of discovery. While these sesterterpenoids were first characterized as highly ef...
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-07-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/15/7/229 |
| _version_ | 1798005151831687168 |
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| author | Wei Tian Zixin Deng Kui Hong |
| author_facet | Wei Tian Zixin Deng Kui Hong |
| author_sort | Wei Tian |
| collection | DOAJ |
| description | Ophiobolins (Ophs) are a group of tricarbocyclic sesterterpenoids whose structures contain a tricyclic 5-8-5 carbotricyclic skeleton. Thus far, 49 natural Ophs have been reported and assigned into A–W subgroups in order of discovery. While these sesterterpenoids were first characterized as highly effective phytotoxins, later investigations demonstrated that they display a broad spectrum of biological and pharmacological characteristics such as phytotoxic, antimicrobial, nematocidal, cytotoxic, anti-influenza and inflammation-promoting activities. These bioactive molecules are promising drug candidates due to the developments of their anti-proliferative activities against a vast number of cancer cell lines, multidrug resistance (MDR) cells and cancer stem cells (CSCs). Despite numerous studies on the biological functions of Ophs, their pharmacological mechanism still requires further research. This review summarizes the chemical structures, sources, and biological activities of the oph family and discusses its mechanisms and structure–activity relationship to lay the foundation for the future developments and applications of these promising molecules. |
| first_indexed | 2024-04-11T12:34:30Z |
| format | Article |
| id | doaj.art-75ff5ac9e0254f07ba79d898b806b598 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-11T12:34:30Z |
| publishDate | 2017-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-75ff5ac9e0254f07ba79d898b806b5982022-12-22T04:23:40ZengMDPI AGMarine Drugs1660-33972017-07-0115722910.3390/md15070229md15070229The Biological Activities of Sesterterpenoid-Type OphiobolinsWei Tian0Zixin Deng1Kui Hong2Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, and Wuhan University School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, ChinaKey Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, and Wuhan University School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, ChinaKey Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, and Wuhan University School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, ChinaOphiobolins (Ophs) are a group of tricarbocyclic sesterterpenoids whose structures contain a tricyclic 5-8-5 carbotricyclic skeleton. Thus far, 49 natural Ophs have been reported and assigned into A–W subgroups in order of discovery. While these sesterterpenoids were first characterized as highly effective phytotoxins, later investigations demonstrated that they display a broad spectrum of biological and pharmacological characteristics such as phytotoxic, antimicrobial, nematocidal, cytotoxic, anti-influenza and inflammation-promoting activities. These bioactive molecules are promising drug candidates due to the developments of their anti-proliferative activities against a vast number of cancer cell lines, multidrug resistance (MDR) cells and cancer stem cells (CSCs). Despite numerous studies on the biological functions of Ophs, their pharmacological mechanism still requires further research. This review summarizes the chemical structures, sources, and biological activities of the oph family and discusses its mechanisms and structure–activity relationship to lay the foundation for the future developments and applications of these promising molecules.https://www.mdpi.com/1660-3397/15/7/229ophiobolinssourcebioactivitiesstructure–activity relationshipmechanisms |
| spellingShingle | Wei Tian Zixin Deng Kui Hong The Biological Activities of Sesterterpenoid-Type Ophiobolins Marine Drugs ophiobolins source bioactivities structure–activity relationship mechanisms |
| title | The Biological Activities of Sesterterpenoid-Type Ophiobolins |
| title_full | The Biological Activities of Sesterterpenoid-Type Ophiobolins |
| title_fullStr | The Biological Activities of Sesterterpenoid-Type Ophiobolins |
| title_full_unstemmed | The Biological Activities of Sesterterpenoid-Type Ophiobolins |
| title_short | The Biological Activities of Sesterterpenoid-Type Ophiobolins |
| title_sort | biological activities of sesterterpenoid type ophiobolins |
| topic | ophiobolins source bioactivities structure–activity relationship mechanisms |
| url | https://www.mdpi.com/1660-3397/15/7/229 |
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