Contact tracing is associated with treatment success of index tuberculosis cases in Uganda
ABSTRACT: OBJECTIVE: To determine the effect of contact tracing on the treatment outcomes of index tuberculosis (TB) cases in Uganda. METHODS: We evaluated TB cases registered at an urban public health facility in Uganda in 2015–2020. We extracted data from the unit's TB and contact tracing re...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-08-01
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| Series: | International Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971221005385 |
| _version_ | 1818722112012025856 |
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| author | Joseph Baruch Baluku Rachael Alele Kabamooli Norah Kajumba Martin Nabwana David Kateete Sarah Kiguli Irene Andia-Biraro |
| author_facet | Joseph Baruch Baluku Rachael Alele Kabamooli Norah Kajumba Martin Nabwana David Kateete Sarah Kiguli Irene Andia-Biraro |
| author_sort | Joseph Baruch Baluku |
| collection | DOAJ |
| description | ABSTRACT: OBJECTIVE: To determine the effect of contact tracing on the treatment outcomes of index tuberculosis (TB) cases in Uganda. METHODS: We evaluated TB cases registered at an urban public health facility in Uganda in 2015–2020. We extracted data from the unit's TB and contact tracing registers. Treatment outcomes were classified as cure, loss to follow-up, death and treatment failure. Treatment success was the sum of cure and treatment completion. RESULTS: Among 778 TB cases, contact tracing was conducted for 455 (58.5%). Compared with cases without contract tracing (n=323), cases with contract tracing (n=455) had higher treatment success (92.5% vs 79.3%) and cure rates (57.1% vs 39.9%) and lower loss to follow-up (3.5% vs 9.3%), treatment failure (0.4% vs 1.6%) and death (3.5% vs 9.9%) (P<0.001). Contact tracing was associated with higher odds of treatment success (adjusted odds ratio (aOR) 3.00, 95% CI 1.92–4.70, P<0.001) and cure (aOR 3.11, 95% CI 1.97–4.90, P<0.001), and lower odds of loss to follow-up (aOR 0.33, (0.13–0.83), P=0.018) and death (aOR 0.38, (0.20–0.72), P=0.003). CONCLUSION: TB contact tracing should be conducted consistently not only for the benefit of identifying new TB cases but also to promote treatment success of index cases. |
| first_indexed | 2024-12-17T20:49:26Z |
| format | Article |
| id | doaj.art-75ffa9aa3f1044d68b3d4502984ad015 |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-12-17T20:49:26Z |
| publishDate | 2021-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-75ffa9aa3f1044d68b3d4502984ad0152022-12-21T21:33:05ZengElsevierInternational Journal of Infectious Diseases1201-97122021-08-01109129136Contact tracing is associated with treatment success of index tuberculosis cases in UgandaJoseph Baruch Baluku0Rachael Alele Kabamooli1Norah Kajumba2Martin Nabwana3David Kateete4Sarah Kiguli5Irene Andia-Biraro6Kiruddu National Referral Hospital, Kampala, Uganda; Makerere University Lung Institute, Kampala, Uganda; Corresponding author: PO Box 26343 Kampala, +256706327972.Kitebi Health Center, Kampala, UgandaKitebi Health Center, Kampala, UgandaMakerere University – Johns Hopkins University Research Collaboration, Kampala, UgandaDepartment of Microbiology and Immunology, Makerere University College of Health SciencesDepartment of Paediatrics and Child Health, Makerere University College of Health SciencesDepartment of Internal Medicine, Makerere University College of Health SciencesABSTRACT: OBJECTIVE: To determine the effect of contact tracing on the treatment outcomes of index tuberculosis (TB) cases in Uganda. METHODS: We evaluated TB cases registered at an urban public health facility in Uganda in 2015–2020. We extracted data from the unit's TB and contact tracing registers. Treatment outcomes were classified as cure, loss to follow-up, death and treatment failure. Treatment success was the sum of cure and treatment completion. RESULTS: Among 778 TB cases, contact tracing was conducted for 455 (58.5%). Compared with cases without contract tracing (n=323), cases with contract tracing (n=455) had higher treatment success (92.5% vs 79.3%) and cure rates (57.1% vs 39.9%) and lower loss to follow-up (3.5% vs 9.3%), treatment failure (0.4% vs 1.6%) and death (3.5% vs 9.9%) (P<0.001). Contact tracing was associated with higher odds of treatment success (adjusted odds ratio (aOR) 3.00, 95% CI 1.92–4.70, P<0.001) and cure (aOR 3.11, 95% CI 1.97–4.90, P<0.001), and lower odds of loss to follow-up (aOR 0.33, (0.13–0.83), P=0.018) and death (aOR 0.38, (0.20–0.72), P=0.003). CONCLUSION: TB contact tracing should be conducted consistently not only for the benefit of identifying new TB cases but also to promote treatment success of index cases.http://www.sciencedirect.com/science/article/pii/S1201971221005385contact tracinginvestigationtuberculosisoutcomessuccessUganda |
| spellingShingle | Joseph Baruch Baluku Rachael Alele Kabamooli Norah Kajumba Martin Nabwana David Kateete Sarah Kiguli Irene Andia-Biraro Contact tracing is associated with treatment success of index tuberculosis cases in Uganda International Journal of Infectious Diseases contact tracing investigation tuberculosis outcomes success Uganda |
| title | Contact tracing is associated with treatment success of index tuberculosis cases in Uganda |
| title_full | Contact tracing is associated with treatment success of index tuberculosis cases in Uganda |
| title_fullStr | Contact tracing is associated with treatment success of index tuberculosis cases in Uganda |
| title_full_unstemmed | Contact tracing is associated with treatment success of index tuberculosis cases in Uganda |
| title_short | Contact tracing is associated with treatment success of index tuberculosis cases in Uganda |
| title_sort | contact tracing is associated with treatment success of index tuberculosis cases in uganda |
| topic | contact tracing investigation tuberculosis outcomes success Uganda |
| url | http://www.sciencedirect.com/science/article/pii/S1201971221005385 |
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