PARK2 Mutation Causes Metabolic Disturbances and Impaired Survival of Human iPSC-Derived Neurons

PARK2 Mutation Causes Metabolic Disturbances and Impaired Survival of Human iPSC-Derived Neurons

The protein parkin, encoded by the PARK2 gene, is vital for mitochondrial homeostasis, and although it has been implicated in Parkinson’s disease (PD), the disease mechanisms remain unclear. We have applied mass spectrometry-based proteomics to investigate the effects of parkin dysfunction on the mi...

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Bibliographic Details
Main Authors: Helle Bogetofte, Pia Jensen, Matias Ryding, Sissel I. Schmidt, Justyna Okarmus, Louise Ritter, Christina S. Worm, Michaela C. Hohnholt, Carla Azevedo, Laurent Roybon, Lasse K. Bak, Helle Waagepetersen, Brent J. Ryan, Richard Wade-Martins, Martin R. Larsen, Morten Meyer
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Parkinson’s
proteomics
oxidative stress
metabolism
survival
mitochondria
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00297/full

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