SARS-CoV-2 seroprevalence in Aden, Yemen: a population-based study
SUMMARY: Background: In Yemen, initial surveillance of coronavirus disease 2019 (COVID-19) focused primarily on patients with symptoms or severe disease. The full spectrum of the disease remains unclear. To the best of the authors’ knowledge, this is the first seroprevalence study performed in Yeme...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-02-01
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| Series: | International Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971221012297 |
| _version_ | 1798034447985016832 |
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| author | Abdulla Salem Bin-Ghouth Sheikh Al-Shoteri Nuha Mahmoud Altaf Musani Nasser Mohsen Baoom Ali Ahmed Al-Waleedi Evans Buliva Eman AbdelKreem Aly Jeremias Domingos Naiene Rosa Crestani Mikiko Senga Amal Barakat Lubna Al-Ariqi Khaled Zein Al-Sakkaf Abeer Shaef Najib Thabit Ahmed Murshed Samuel Omara |
| author_facet | Abdulla Salem Bin-Ghouth Sheikh Al-Shoteri Nuha Mahmoud Altaf Musani Nasser Mohsen Baoom Ali Ahmed Al-Waleedi Evans Buliva Eman AbdelKreem Aly Jeremias Domingos Naiene Rosa Crestani Mikiko Senga Amal Barakat Lubna Al-Ariqi Khaled Zein Al-Sakkaf Abeer Shaef Najib Thabit Ahmed Murshed Samuel Omara |
| author_sort | Abdulla Salem Bin-Ghouth |
| collection | DOAJ |
| description | SUMMARY: Background: In Yemen, initial surveillance of coronavirus disease 2019 (COVID-19) focused primarily on patients with symptoms or severe disease. The full spectrum of the disease remains unclear. To the best of the authors’ knowledge, this is the first seroprevalence study performed in Yemen. Methods: This cross-sectional investigation included 2001 participants from all age groups from four districts in Aden, southern Yemen. A multi-stage sampling method was used. Data were collected using a well-structured questionnaire, and blood samples were taken. Healgen COVID-19 IgG/IgM Rapid Diagnostic Test (RDT) Cassettes were used in all participants. All positive RDTs and 14% of negative RDTs underwent enzyme-linked immunosorbent assay (ELISA) testing (WANTAI SARS-CoV-2 Ab ELISA Kit) for confirmation. Results: In total, 549 of 2001 participants were RDT positive and confirmed by ELISA, giving a prevalence of COVID-19 of 27.4%. The prevalence of immunoglobulin G was 25%. The prevalence of asymptomatic COVID-19 in the entire study group was 7.9%. The highest prevalence was observed in Al-Mansurah district (33.4%). Regarding sociodemographic factors, the prevalence of COVID-19 was significantly higher among females, housewives and subjects with a history of contact with a COVID-19 patient: 32%, 31% and 39%, respectively. Conclusion: This study found high prevalence of COVID-19 in the study population. Household transmission was common. |
| first_indexed | 2024-04-11T20:43:28Z |
| format | Article |
| id | doaj.art-7600302e92314a2c943964874d02ba1e |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-04-11T20:43:28Z |
| publishDate | 2022-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-7600302e92314a2c943964874d02ba1e2022-12-22T04:04:06ZengElsevierInternational Journal of Infectious Diseases1201-97122022-02-01115239244SARS-CoV-2 seroprevalence in Aden, Yemen: a population-based studyAbdulla Salem Bin-Ghouth0Sheikh Al-Shoteri1Nuha Mahmoud2Altaf Musani3Nasser Mohsen Baoom4Ali Ahmed Al-Waleedi5Evans Buliva6Eman AbdelKreem Aly7Jeremias Domingos Naiene8Rosa Crestani9Mikiko Senga10Amal Barakat11Lubna Al-Ariqi12Khaled Zein Al-Sakkaf13Abeer Shaef14Najib Thabit15Ahmed Murshed16Samuel Omara17College of Medicine, Hadhramout University, Mukalla, Yemen; Corresponding author. College of Medicine, Hadhramout University, Post Box 8892, Mukalla, Yemen.Aden University, YemenWorld Health Organization Country Office, YemenWorld Health Organization Country Office, YemenMinistry of Public Health and Population, YemenMinistry of Public Health and Population, YemenWorld Health Organization Eastern Mediterranean Regional Office, Cairo, EgyptWorld Health Organization Eastern Mediterranean Regional Office, Cairo, EgyptWorld Health Organization Eastern Mediterranean Regional Office, Cairo, EgyptWorld Health Organization Eastern Mediterranean Regional Office, Cairo, EgyptWorld Health Organization Eastern Mediterranean Regional Office, Cairo, EgyptWorld Health Organization Eastern Mediterranean Regional Office, Cairo, EgyptWorld Health Organization Eastern Mediterranean Regional Office, Cairo, EgyptAden University, YemenAden University, YemenWorld Health Organization Country Office, YemenWorld Health Organization Country Office, YemenWorld Health Organization Country Office, YemenSUMMARY: Background: In Yemen, initial surveillance of coronavirus disease 2019 (COVID-19) focused primarily on patients with symptoms or severe disease. The full spectrum of the disease remains unclear. To the best of the authors’ knowledge, this is the first seroprevalence study performed in Yemen. Methods: This cross-sectional investigation included 2001 participants from all age groups from four districts in Aden, southern Yemen. A multi-stage sampling method was used. Data were collected using a well-structured questionnaire, and blood samples were taken. Healgen COVID-19 IgG/IgM Rapid Diagnostic Test (RDT) Cassettes were used in all participants. All positive RDTs and 14% of negative RDTs underwent enzyme-linked immunosorbent assay (ELISA) testing (WANTAI SARS-CoV-2 Ab ELISA Kit) for confirmation. Results: In total, 549 of 2001 participants were RDT positive and confirmed by ELISA, giving a prevalence of COVID-19 of 27.4%. The prevalence of immunoglobulin G was 25%. The prevalence of asymptomatic COVID-19 in the entire study group was 7.9%. The highest prevalence was observed in Al-Mansurah district (33.4%). Regarding sociodemographic factors, the prevalence of COVID-19 was significantly higher among females, housewives and subjects with a history of contact with a COVID-19 patient: 32%, 31% and 39%, respectively. Conclusion: This study found high prevalence of COVID-19 in the study population. Household transmission was common.http://www.sciencedirect.com/science/article/pii/S1201971221012297AntibodiesCOVID-19 serosurveyELISAImmunitySARS-CoV-2 sero-epidemiology |
| spellingShingle | Abdulla Salem Bin-Ghouth Sheikh Al-Shoteri Nuha Mahmoud Altaf Musani Nasser Mohsen Baoom Ali Ahmed Al-Waleedi Evans Buliva Eman AbdelKreem Aly Jeremias Domingos Naiene Rosa Crestani Mikiko Senga Amal Barakat Lubna Al-Ariqi Khaled Zein Al-Sakkaf Abeer Shaef Najib Thabit Ahmed Murshed Samuel Omara SARS-CoV-2 seroprevalence in Aden, Yemen: a population-based study International Journal of Infectious Diseases Antibodies COVID-19 serosurvey ELISA Immunity SARS-CoV-2 sero-epidemiology |
| title | SARS-CoV-2 seroprevalence in Aden, Yemen: a population-based study |
| title_full | SARS-CoV-2 seroprevalence in Aden, Yemen: a population-based study |
| title_fullStr | SARS-CoV-2 seroprevalence in Aden, Yemen: a population-based study |
| title_full_unstemmed | SARS-CoV-2 seroprevalence in Aden, Yemen: a population-based study |
| title_short | SARS-CoV-2 seroprevalence in Aden, Yemen: a population-based study |
| title_sort | sars cov 2 seroprevalence in aden yemen a population based study |
| topic | Antibodies COVID-19 serosurvey ELISA Immunity SARS-CoV-2 sero-epidemiology |
| url | http://www.sciencedirect.com/science/article/pii/S1201971221012297 |
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