Dual-targeting CD44 and mucin by hyaluronic acid and 5TR1 aptamer for epirubicin delivery into cancer cells: Synthesis, characterization, in vitro and in vivo evaluation

Dual-targeting CD44 and mucin by hyaluronic acid and 5TR1 aptamer for epirubicin delivery into cancer cells: Synthesis, characterization, in vitro and in vivo evaluation

One of the revolutionized cancer treatment is active targeting nanomedicines. This study aims to create a dual-targeted drug delivery system for Epirubicin (EPI) to cancer cells. Hyaluronic acid (HA) is the first targeting ligand, and 5TR1 aptamer (5TR1) is the second targeting ligand to guide the d...

Full description

Bibliographic Details
Main Authors: Zahra Jamshidi, Reza Dehghan, Mojgan Nejabat, Khalil Abnous, Seyed Mohammad Taghdisi, Farzin Hadizadeh
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Heliyon
Subjects:
Breast cancer
Epirubicin
Hyaluronic acid
MUC1
5TR1 aptamer
Targeted drug delivery
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024008648

Similar Items

Similar Items