Induction of human somatostatin and parvalbumin neurons by expressing a single transcription factor LIM homeobox 6

Induction of human somatostatin and parvalbumin neurons by expressing a single transcription factor LIM homeobox 6

Human GABAergic interneurons (GIN) are implicated in normal brain function and in numerous mental disorders. However, the generation of functional human GIN subtypes from human pluripotent stem cells (hPSCs) has not been established. By expressing LHX6, a transcriptional factor that is critical for...

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Bibliographic Details
Main Authors: Fang Yuan, Xin Chen, Kai-Heng Fang, Yuanyuan Wang, Mingyan Lin, Shi-Bo Xu, Hai-Qin Huo, Min Xu, Lixiang Ma, Yuejun Chen, Shuijin He, Yan Liu
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-09-01
Series:eLife
Subjects:
direct differentiation
PV neuron
SST neuron
HiPSCs
Online Access:https://elifesciences.org/articles/37382

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