Silencing SHMT2 inhibits the progression of tongue squamous cell carcinoma through cell cycle regulation

Silencing SHMT2 inhibits the progression of tongue squamous cell carcinoma through cell cycle regulation

Abstract Background Serine hydroxymethyltransferase 2 (SHMT2) is a vital metabolic enzyme in one carbon metabolism catalyzing the conversion of serine to glycine, which has been reported to play a crucial role in the progression of tumors. However, its function in tongue squamous cell carcinoma (TSC...

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Bibliographic Details
Main Authors: Yan Liao, Fang Wang, Yadong Zhang, Hongshi Cai, Fan Song, Jinsong Hou
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Cancer Cell International
Subjects:
SHMT2
Tongue squamous cell carcinoma
Survival analysis
Cell cycle
Weighted gene co-expression network analysis
Gene set enrichment analysis
Online Access:https://doi.org/10.1186/s12935-021-01880-5

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