Factors Associated with Treatment Prescription to Pulmonary Tuberculosis Contacts in Catalonia (2019–2021): A Population-Based Epidemiological Study
In countries with low tuberculosis (TB) incidence, the systematic testing and treatment of latent TB infection (LTBI) in contacts of pulmonary TB index cases is the standard of care. The objective of this study, conducted in Catalonia over 2019–2021, was to assess the factors associated with LTBI tr...
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| Format: | Article |
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MDPI AG
2023-12-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/11/12/1800 |
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| author | Ángela Domínguez Núria Soldevila Diana Toledo Ignasi Parrón Joan-Pau Millet Irene Barrabeig Pere Godoy on behalf of Transmission of Tuberculosis in Catalonia (Spain) Working Group |
| author_facet | Ángela Domínguez Núria Soldevila Diana Toledo Ignasi Parrón Joan-Pau Millet Irene Barrabeig Pere Godoy on behalf of Transmission of Tuberculosis in Catalonia (Spain) Working Group |
| author_sort | Ángela Domínguez |
| collection | DOAJ |
| description | In countries with low tuberculosis (TB) incidence, the systematic testing and treatment of latent TB infection (LTBI) in contacts of pulmonary TB index cases is the standard of care. The objective of this study, conducted in Catalonia over 2019–2021, was to assess the factors associated with LTBI treatment prescription to close contacts of pulmonary TB index cases. In this population-based epidemiological study of LTBI prevalence among pulmonary TB contacts between 2019 and 2021, multiple logistic backward stepwise regression was used to identify the factors associated with treatment prescription, for which the adjusted odds ratio (aOR) and 95% confidence intervals (CI) were calculated. A total of 1487 LTBI contacts of 542 pulmonary TB index cases were studied, 80.6% of whom received a prescription. The factors associated with LTBI treatment prescription were exposure ≥6 h/day (aOR 14.20; 95% CI 5.22–38.66) and exposure <6 h/day (aOR 7.32, 95% CI 2.48–21.64), whereas the factors associated with no LTBI treatment prescription were age ≥55 years (aOR 0.22, 95% CI 0.08–0.64) and bacillus Calmette–Guerin vaccination (aOR 0.38, 95% CI 0.16–0.90). Crucial to LTBI treatment prescription is information on the contact’s duration of exposure to pulmonary TB, not only for contacts exposed for ≥6 h/day, but also for contacts with lower daily exposure levels. |
| first_indexed | 2024-03-08T20:18:10Z |
| format | Article |
| id | doaj.art-76032033a6d14d41b529d7176567df09 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-08T20:18:10Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-76032033a6d14d41b529d7176567df092023-12-22T14:47:11ZengMDPI AGVaccines2076-393X2023-12-011112180010.3390/vaccines11121800Factors Associated with Treatment Prescription to Pulmonary Tuberculosis Contacts in Catalonia (2019–2021): A Population-Based Epidemiological StudyÁngela Domínguez0Núria Soldevila1Diana Toledo2Ignasi Parrón3Joan-Pau Millet4Irene Barrabeig5Pere Godoy6on behalf of Transmission of Tuberculosis in Catalonia (Spain) Working GroupDepartament de Medicina, Universitat de Barcelona, 08036 Barcelona, SpainDepartament de Medicina, Universitat de Barcelona, 08036 Barcelona, SpainDepartament de Medicina, Universitat de Barcelona, 08036 Barcelona, SpainAgència de Salut Publica de Catalunya, 08005 Barcelona, SpainCIBER de Epidemiología y Salud Pública (CIBERESP), 28029 Madrid, SpainCIBER de Epidemiología y Salud Pública (CIBERESP), 28029 Madrid, SpainCIBER de Epidemiología y Salud Pública (CIBERESP), 28029 Madrid, SpainIn countries with low tuberculosis (TB) incidence, the systematic testing and treatment of latent TB infection (LTBI) in contacts of pulmonary TB index cases is the standard of care. The objective of this study, conducted in Catalonia over 2019–2021, was to assess the factors associated with LTBI treatment prescription to close contacts of pulmonary TB index cases. In this population-based epidemiological study of LTBI prevalence among pulmonary TB contacts between 2019 and 2021, multiple logistic backward stepwise regression was used to identify the factors associated with treatment prescription, for which the adjusted odds ratio (aOR) and 95% confidence intervals (CI) were calculated. A total of 1487 LTBI contacts of 542 pulmonary TB index cases were studied, 80.6% of whom received a prescription. The factors associated with LTBI treatment prescription were exposure ≥6 h/day (aOR 14.20; 95% CI 5.22–38.66) and exposure <6 h/day (aOR 7.32, 95% CI 2.48–21.64), whereas the factors associated with no LTBI treatment prescription were age ≥55 years (aOR 0.22, 95% CI 0.08–0.64) and bacillus Calmette–Guerin vaccination (aOR 0.38, 95% CI 0.16–0.90). Crucial to LTBI treatment prescription is information on the contact’s duration of exposure to pulmonary TB, not only for contacts exposed for ≥6 h/day, but also for contacts with lower daily exposure levels.https://www.mdpi.com/2076-393X/11/12/1800contact tracingtuberculosislatent TB infectiontreatmentprescriptionprevention |
| spellingShingle | Ángela Domínguez Núria Soldevila Diana Toledo Ignasi Parrón Joan-Pau Millet Irene Barrabeig Pere Godoy on behalf of Transmission of Tuberculosis in Catalonia (Spain) Working Group Factors Associated with Treatment Prescription to Pulmonary Tuberculosis Contacts in Catalonia (2019–2021): A Population-Based Epidemiological Study Vaccines contact tracing tuberculosis latent TB infection treatment prescription prevention |
| title | Factors Associated with Treatment Prescription to Pulmonary Tuberculosis Contacts in Catalonia (2019–2021): A Population-Based Epidemiological Study |
| title_full | Factors Associated with Treatment Prescription to Pulmonary Tuberculosis Contacts in Catalonia (2019–2021): A Population-Based Epidemiological Study |
| title_fullStr | Factors Associated with Treatment Prescription to Pulmonary Tuberculosis Contacts in Catalonia (2019–2021): A Population-Based Epidemiological Study |
| title_full_unstemmed | Factors Associated with Treatment Prescription to Pulmonary Tuberculosis Contacts in Catalonia (2019–2021): A Population-Based Epidemiological Study |
| title_short | Factors Associated with Treatment Prescription to Pulmonary Tuberculosis Contacts in Catalonia (2019–2021): A Population-Based Epidemiological Study |
| title_sort | factors associated with treatment prescription to pulmonary tuberculosis contacts in catalonia 2019 2021 a population based epidemiological study |
| topic | contact tracing tuberculosis latent TB infection treatment prescription prevention |
| url | https://www.mdpi.com/2076-393X/11/12/1800 |
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