The Prognostic Role of p16 Expression in Tonsil Cancer Treated by Either Surgery or Radiation
ObjectivesAlthough human papillomavirus (HPV) infection is considered as a favorable prognostic factor in oropharyngeal cancer, the prognosis of HPV-associated tonsil cancer has rarely been studied especially when surgery was the main treatment. In this study, the authors investigated the effect of...
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Format: | Article |
Language: | English |
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Korean Society of Otorhinolaryngology-Head and Neck Surgery
2012-12-01
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Series: | Clinical and Experimental Otorhinolaryngology |
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Online Access: | http://www.e-ceo.org/upload/pdf/ceo-5-207.pdf |
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author | Tae Wook Kim Sung Yong Choi Young Hyeh Ko Chung-Hwan Baek Young-Ik Son |
author_facet | Tae Wook Kim Sung Yong Choi Young Hyeh Ko Chung-Hwan Baek Young-Ik Son |
author_sort | Tae Wook Kim |
collection | DOAJ |
description | ObjectivesAlthough human papillomavirus (HPV) infection is considered as a favorable prognostic factor in oropharyngeal cancer, the prognosis of HPV-associated tonsil cancer has rarely been studied especially when surgery was the main treatment. In this study, the authors investigated the effect of p16 over-expression (HPV infection) on tonsil cancer prognosis according to the type of treatment, HPV presence by PCR, and expression of p53 and epidermal growth factor receptor (EGFR) by immunohistochemistry (IHC).MethodsMedical records of 33 tonsil cancer patients were reviewed. Using formalin-fixed and paraffin-embedded tumor specimens, PCR-based genotyping of HPV and IHC of p16, p53 and EGFR were performed. The effects of HPV presence and the expression of IHC markers were analyzed on the recurrence-free survival. Five-year disease-free survival (DFS) rates were evaluated according to p16 expression status.ResultsAn over-expression of p16 was observed in 27 (81.9%) out of 33 cases. Surgery-based treatment was provided for 21 (63.6%) patients. There was no association between p16 immunoreactivity and HPV presence, nor with p53 and EGFR expression. Regardless of main treatment modalities, five-year DFS did not differ by p16 expression status (P=0.051). However, over-expression of p16 was associated with a lower recurrence in multivariable analyses (P=0.046).ConclusionRegardless of main treatment modalities, an over-expression of p16 (HPV infection) is associated with a lower recurrence in tonsil cancers. However it is not associated with simple HPV presence or p53 and EGFR over-expression. |
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institution | Directory Open Access Journal |
issn | 1976-8710 2005-0720 |
language | English |
last_indexed | 2024-04-12T19:21:39Z |
publishDate | 2012-12-01 |
publisher | Korean Society of Otorhinolaryngology-Head and Neck Surgery |
record_format | Article |
series | Clinical and Experimental Otorhinolaryngology |
spelling | doaj.art-7608408ee90241f2b8b26ce213929e512022-12-22T03:19:34ZengKorean Society of Otorhinolaryngology-Head and Neck SurgeryClinical and Experimental Otorhinolaryngology1976-87102005-07202012-12-015420721210.3342/ceo.2012.5.4.207186The Prognostic Role of p16 Expression in Tonsil Cancer Treated by Either Surgery or RadiationTae Wook Kim0Sung Yong Choi1Young Hyeh Ko2Chung-Hwan Baek3Young-Ik Son4Department of Otorhinolaryngology, Incheon Medical Center, Incheon, Korea.Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.ObjectivesAlthough human papillomavirus (HPV) infection is considered as a favorable prognostic factor in oropharyngeal cancer, the prognosis of HPV-associated tonsil cancer has rarely been studied especially when surgery was the main treatment. In this study, the authors investigated the effect of p16 over-expression (HPV infection) on tonsil cancer prognosis according to the type of treatment, HPV presence by PCR, and expression of p53 and epidermal growth factor receptor (EGFR) by immunohistochemistry (IHC).MethodsMedical records of 33 tonsil cancer patients were reviewed. Using formalin-fixed and paraffin-embedded tumor specimens, PCR-based genotyping of HPV and IHC of p16, p53 and EGFR were performed. The effects of HPV presence and the expression of IHC markers were analyzed on the recurrence-free survival. Five-year disease-free survival (DFS) rates were evaluated according to p16 expression status.ResultsAn over-expression of p16 was observed in 27 (81.9%) out of 33 cases. Surgery-based treatment was provided for 21 (63.6%) patients. There was no association between p16 immunoreactivity and HPV presence, nor with p53 and EGFR expression. Regardless of main treatment modalities, five-year DFS did not differ by p16 expression status (P=0.051). However, over-expression of p16 was associated with a lower recurrence in multivariable analyses (P=0.046).ConclusionRegardless of main treatment modalities, an over-expression of p16 (HPV infection) is associated with a lower recurrence in tonsil cancers. However it is not associated with simple HPV presence or p53 and EGFR over-expression.http://www.e-ceo.org/upload/pdf/ceo-5-207.pdfHuman papillomavirusOropharyngeal neoplasmsTherapeuticsImmunohistochemistryPrognosisp16 (INK4A) |
spellingShingle | Tae Wook Kim Sung Yong Choi Young Hyeh Ko Chung-Hwan Baek Young-Ik Son The Prognostic Role of p16 Expression in Tonsil Cancer Treated by Either Surgery or Radiation Clinical and Experimental Otorhinolaryngology Human papillomavirus Oropharyngeal neoplasms Therapeutics Immunohistochemistry Prognosis p16 (INK4A) |
title | The Prognostic Role of p16 Expression in Tonsil Cancer Treated by Either Surgery or Radiation |
title_full | The Prognostic Role of p16 Expression in Tonsil Cancer Treated by Either Surgery or Radiation |
title_fullStr | The Prognostic Role of p16 Expression in Tonsil Cancer Treated by Either Surgery or Radiation |
title_full_unstemmed | The Prognostic Role of p16 Expression in Tonsil Cancer Treated by Either Surgery or Radiation |
title_short | The Prognostic Role of p16 Expression in Tonsil Cancer Treated by Either Surgery or Radiation |
title_sort | prognostic role of p16 expression in tonsil cancer treated by either surgery or radiation |
topic | Human papillomavirus Oropharyngeal neoplasms Therapeutics Immunohistochemistry Prognosis p16 (INK4A) |
url | http://www.e-ceo.org/upload/pdf/ceo-5-207.pdf |
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