Validity and reliability of CDAI in comparison to DAS28 in Iraqi patients with active rheumatoid arthritis
Background: Rheumatoid arthritis (RA) disease activity plays a central role in causing disability both directly and via indirect effects mediated through joint damage. Evaluation of RA disease activity is therefore important to predict the outcome and effectiveness of therapeutic interventions durin...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
College of Medicine University of Baghdad
2012-10-01
|
| Series: | مجلة كلية الطب |
| Subjects: | |
| Online Access: | http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/724 |
| _version_ | 1797370155487985664 |
|---|---|
| author | Faiq I. Gorial |
| author_facet | Faiq I. Gorial |
| author_sort | Faiq I. Gorial |
| collection | DOAJ |
| description | Background: Rheumatoid arthritis (RA) disease activity plays a central role in causing disability both directly and via indirect effects mediated through joint damage. Evaluation of RA disease activity is therefore important to predict the outcome and effectiveness of therapeutic interventions during follow-up. Clinical disease activity index (CDAI) is new simple tool for measurement of disease activity.
Objectives: To assess validity and reliability of CDAI in comparison to disease activity score-28 joints (DAS28) in Iraqi patients with active RA.
Patients and Methods: Sixty nine Iraqi RA patients were included in this study. All patients were fulfilling the ACR classification criteria and active. Full history was taken and complete clinical examination was done for all patients. Patients’ age, sex, duration of the disease, number of tender joints, number of swollen joints, patient’s and physician’s (evaluator) global assessment by visual analogue scale (VAS) (0–10 cm) were recorded. Laboratory analysis included erythrocyte sedimentation rate (ESR). CDAI and DAS28 were measured to assess disease activity.
Results: Of 69 patients included in this study, there were 58 women and 11 men. Mean age of the patients was 45.65±12.26 years and mean duration of disease was 7.75±7.85 years. Mean DAS28 and CDAI were 5.86±1.24 and 30.07±14.07respectively.There was direct significant correlation between CDAI and DAS28 (r= 0.879, P< 0.001). Also we found good agreement between CDAI and DAS28 (Kappa = 0.795, P < 0.001). CDAI had sensitivity 90%, specificity 92%, Likelihood ratio (LR) 45.67, Area under the curve (AUC) 0.983 [95% confidence interval (CI) 0.933-1.000] (P value < 0.001).
Conclusions: CDAI is a valid and reliable measure for assessment of Iraqi patients with active RA in comparison to DAS28. |
| first_indexed | 2024-03-08T17:58:20Z |
| format | Article |
| id | doaj.art-7608e5a8259645c18ba331a95dddb0b0 |
| institution | Directory Open Access Journal |
| issn | 0041-9419 2410-8057 |
| language | English |
| last_indexed | 2024-03-08T17:58:20Z |
| publishDate | 2012-10-01 |
| publisher | College of Medicine University of Baghdad |
| record_format | Article |
| series | مجلة كلية الطب |
| spelling | doaj.art-7608e5a8259645c18ba331a95dddb0b02024-01-02T03:55:43ZengCollege of Medicine University of Baghdadمجلة كلية الطب0041-94192410-80572012-10-0154310.32007/jfacmedbagdad.v3231-233%Validity and reliability of CDAI in comparison to DAS28 in Iraqi patients with active rheumatoid arthritisFaiq I. Gorial0Department of Medicine, Medical Rheumatology Unit. , College of Medicine, Baghdad University.Background: Rheumatoid arthritis (RA) disease activity plays a central role in causing disability both directly and via indirect effects mediated through joint damage. Evaluation of RA disease activity is therefore important to predict the outcome and effectiveness of therapeutic interventions during follow-up. Clinical disease activity index (CDAI) is new simple tool for measurement of disease activity. Objectives: To assess validity and reliability of CDAI in comparison to disease activity score-28 joints (DAS28) in Iraqi patients with active RA. Patients and Methods: Sixty nine Iraqi RA patients were included in this study. All patients were fulfilling the ACR classification criteria and active. Full history was taken and complete clinical examination was done for all patients. Patients’ age, sex, duration of the disease, number of tender joints, number of swollen joints, patient’s and physician’s (evaluator) global assessment by visual analogue scale (VAS) (0–10 cm) were recorded. Laboratory analysis included erythrocyte sedimentation rate (ESR). CDAI and DAS28 were measured to assess disease activity. Results: Of 69 patients included in this study, there were 58 women and 11 men. Mean age of the patients was 45.65±12.26 years and mean duration of disease was 7.75±7.85 years. Mean DAS28 and CDAI were 5.86±1.24 and 30.07±14.07respectively.There was direct significant correlation between CDAI and DAS28 (r= 0.879, P< 0.001). Also we found good agreement between CDAI and DAS28 (Kappa = 0.795, P < 0.001). CDAI had sensitivity 90%, specificity 92%, Likelihood ratio (LR) 45.67, Area under the curve (AUC) 0.983 [95% confidence interval (CI) 0.933-1.000] (P value < 0.001). Conclusions: CDAI is a valid and reliable measure for assessment of Iraqi patients with active RA in comparison to DAS28.http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/724Clinical disease activity index, disease activity score 28 joints, rheumatoid arthritis activity. |
| spellingShingle | Faiq I. Gorial Validity and reliability of CDAI in comparison to DAS28 in Iraqi patients with active rheumatoid arthritis مجلة كلية الطب Clinical disease activity index, disease activity score 28 joints, rheumatoid arthritis activity. |
| title | Validity and reliability of CDAI in comparison to DAS28 in Iraqi patients with active rheumatoid arthritis |
| title_full | Validity and reliability of CDAI in comparison to DAS28 in Iraqi patients with active rheumatoid arthritis |
| title_fullStr | Validity and reliability of CDAI in comparison to DAS28 in Iraqi patients with active rheumatoid arthritis |
| title_full_unstemmed | Validity and reliability of CDAI in comparison to DAS28 in Iraqi patients with active rheumatoid arthritis |
| title_short | Validity and reliability of CDAI in comparison to DAS28 in Iraqi patients with active rheumatoid arthritis |
| title_sort | validity and reliability of cdai in comparison to das28 in iraqi patients with active rheumatoid arthritis |
| topic | Clinical disease activity index, disease activity score 28 joints, rheumatoid arthritis activity. |
| url | http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/724 |
| work_keys_str_mv | AT faiqigorial validityandreliabilityofcdaiincomparisontodas28iniraqipatientswithactiverheumatoidarthritis |