Pulsed low dose-rate irradiation response in isogenic HNSCC cell lines with different radiosensitivity
Management of locoregionally recurrent head and neck squamous cell carcinomas (HNSCC) is challenging due to potential radioresistance. Pulsed low-dose rate (PLDR) irradiation exploits phenomena of increased radiosensitivity, low-dose hyperradiosensitivity (LDHRS), and inverse dose-rate effect. The p...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Sciendo
2020-03-01
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| Series: | Radiology and Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.2478/raon-2020-0015 |
| _version_ | 1819078921024438272 |
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| author | Todorovic Vesna Prevc Ajda Zakelj Martina Niksic Savarin Monika Bucek Simon Groselj Blaz Strojan Primoz Cemazar Maja Sersa Gregor |
| author_facet | Todorovic Vesna Prevc Ajda Zakelj Martina Niksic Savarin Monika Bucek Simon Groselj Blaz Strojan Primoz Cemazar Maja Sersa Gregor |
| author_sort | Todorovic Vesna |
| collection | DOAJ |
| description | Management of locoregionally recurrent head and neck squamous cell carcinomas (HNSCC) is challenging due to potential radioresistance. Pulsed low-dose rate (PLDR) irradiation exploits phenomena of increased radiosensitivity, low-dose hyperradiosensitivity (LDHRS), and inverse dose-rate effect. The purpose of this study was to evaluate LDHRS and the effect of PLDR irradiation in isogenic HNSCC cells with different radiosensitivity. |
| first_indexed | 2024-12-21T19:20:46Z |
| format | Article |
| id | doaj.art-76091ca792e74542bcf02eed90d7c195 |
| institution | Directory Open Access Journal |
| issn | 1581-3207 |
| language | English |
| last_indexed | 2024-12-21T19:20:46Z |
| publishDate | 2020-03-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Radiology and Oncology |
| spelling | doaj.art-76091ca792e74542bcf02eed90d7c1952022-12-21T18:52:56ZengSciendoRadiology and Oncology1581-32072020-03-0154216817910.2478/raon-2020-0015raon-2020-0015Pulsed low dose-rate irradiation response in isogenic HNSCC cell lines with different radiosensitivityTodorovic Vesna0Prevc Ajda1Zakelj Martina Niksic2Savarin Monika3Bucek Simon4Groselj Blaz5Strojan Primoz6Cemazar Maja7Sersa Gregor8Institute of Oncology Ljubljana, Department of Experimental Oncology, Ljubljana, SloveniaInstitute of Oncology Ljubljana, Department of Experimental Oncology, Ljubljana, SloveniaInstitute of Oncology Ljubljana, Department of Experimental Oncology, Ljubljana, SloveniaInstitute of Oncology Ljubljana, Department of Experimental Oncology, Ljubljana, SloveniaInstitute of Oncology Ljubljana, Department of Cytopathology, Ljubljana, SloveniaInstitute of Oncology Ljubljana, Department of Radiation Oncology, Ljubljana, SloveniaInstitute of Oncology Ljubljana, Department of Radiation Oncology, Ljubljana, SloveniaInstitute of Oncology Ljubljana, Department of Experimental Oncology, Ljubljana, SloveniaInstitute of Oncology Ljubljana, Department of Experimental Oncology, Ljubljana, SloveniaManagement of locoregionally recurrent head and neck squamous cell carcinomas (HNSCC) is challenging due to potential radioresistance. Pulsed low-dose rate (PLDR) irradiation exploits phenomena of increased radiosensitivity, low-dose hyperradiosensitivity (LDHRS), and inverse dose-rate effect. The purpose of this study was to evaluate LDHRS and the effect of PLDR irradiation in isogenic HNSCC cells with different radiosensitivity.https://doi.org/10.2478/raon-2020-0015dna damageisogenic cell lineslow dose irradiationpulsed low dose-rate irradiationradiosensitivity |
| spellingShingle | Todorovic Vesna Prevc Ajda Zakelj Martina Niksic Savarin Monika Bucek Simon Groselj Blaz Strojan Primoz Cemazar Maja Sersa Gregor Pulsed low dose-rate irradiation response in isogenic HNSCC cell lines with different radiosensitivity Radiology and Oncology dna damage isogenic cell lines low dose irradiation pulsed low dose-rate irradiation radiosensitivity |
| title | Pulsed low dose-rate irradiation response in isogenic HNSCC cell lines with different radiosensitivity |
| title_full | Pulsed low dose-rate irradiation response in isogenic HNSCC cell lines with different radiosensitivity |
| title_fullStr | Pulsed low dose-rate irradiation response in isogenic HNSCC cell lines with different radiosensitivity |
| title_full_unstemmed | Pulsed low dose-rate irradiation response in isogenic HNSCC cell lines with different radiosensitivity |
| title_short | Pulsed low dose-rate irradiation response in isogenic HNSCC cell lines with different radiosensitivity |
| title_sort | pulsed low dose rate irradiation response in isogenic hnscc cell lines with different radiosensitivity |
| topic | dna damage isogenic cell lines low dose irradiation pulsed low dose-rate irradiation radiosensitivity |
| url | https://doi.org/10.2478/raon-2020-0015 |
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