Pulsed low dose-rate irradiation response in isogenic HNSCC cell lines with different radiosensitivity

Pulsed low dose-rate irradiation response in isogenic HNSCC cell lines with different radiosensitivity

Management of locoregionally recurrent head and neck squamous cell carcinomas (HNSCC) is challenging due to potential radioresistance. Pulsed low-dose rate (PLDR) irradiation exploits phenomena of increased radiosensitivity, low-dose hyperradiosensitivity (LDHRS), and inverse dose-rate effect. The p...

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Bibliographic Details
Main Authors: Todorovic Vesna, Prevc Ajda, Zakelj Martina Niksic, Savarin Monika, Bucek Simon, Groselj Blaz, Strojan Primoz, Cemazar Maja, Sersa Gregor
Format: Article
Language:English
Published: Sciendo 2020-03-01
Series:Radiology and Oncology
Subjects:
dna damage
isogenic cell lines
low dose irradiation
pulsed low dose-rate irradiation
radiosensitivity
Online Access:https://doi.org/10.2478/raon-2020-0015

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