Early predictors of conversion in patients with clinically isolated syndrome: a preliminary Egyptian study
Abstract Background Clinically isolated syndrome (CIS) is the first neurologic episode of multiple sclerosis (MS). Clinical presentation, neurophysiological studies, and magnetic resonance imaging (MRI) are used to predict risk of conversion to MS. There is little information regarding the risk fact...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2018-07-01
|
| Series: | The Egyptian Journal of Neurology, Psychiatry and Neurosurgery |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s41983-018-0021-3 |
| _version_ | 1831761895595442176 |
|---|---|
| author | Hala A. Shaheen Sayed S. Sayed Lamiaa I. Daker Mohamed A. Taha |
| author_facet | Hala A. Shaheen Sayed S. Sayed Lamiaa I. Daker Mohamed A. Taha |
| author_sort | Hala A. Shaheen |
| collection | DOAJ |
| description | Abstract Background Clinically isolated syndrome (CIS) is the first neurologic episode of multiple sclerosis (MS). Clinical presentation, neurophysiological studies, and magnetic resonance imaging (MRI) are used to predict risk of conversion to MS. There is little information regarding the risk factors of CIS conversion to MS so far in the Egyptian patients. This study aimed to evaluate the predictors of early conversion of the Egyptian patients with CIS to MS. Methods A longitudinal prospective study was conducted on 43 Egyptian patients diagnosed as CIS according to the McDonald criteria (2010). The CIS patients underwent clinical assessment of disability using Expanded Disability Status Scale(EDSS), brain imaging by magnetic resonance imaging (MRI), and visual evoked potential (VEP) at baseline and after 1-year follow-up. Results Eight patients (19.6%) with CIS converted to clinically definite MS after 1 year. A logistic regression analysis revealed that the CIS patients with initial clinical presentation with optic neuritis and higher MRI brain lesion number were associated with early conversion to MS (p = 0.003, p = 0.002, respectively). The total MRI brain T2 lesion number that predicts early conversion to MS was four lesions with sensitivity (100%) and specificity (85.7%). Conclusions The patients with CIS that early presented with optic neuritis and higher MRI brain lesion number are at higher risk for conversion to clinically definite MS. |
| first_indexed | 2024-12-22T04:57:17Z |
| format | Article |
| id | doaj.art-760951e589d14a46ae4cd330b69ead35 |
| institution | Directory Open Access Journal |
| issn | 1687-8329 |
| language | English |
| last_indexed | 2024-12-22T04:57:17Z |
| publishDate | 2018-07-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Neurology, Psychiatry and Neurosurgery |
| spelling | doaj.art-760951e589d14a46ae4cd330b69ead352022-12-21T18:38:21ZengSpringerOpenThe Egyptian Journal of Neurology, Psychiatry and Neurosurgery1687-83292018-07-015411510.1186/s41983-018-0021-3Early predictors of conversion in patients with clinically isolated syndrome: a preliminary Egyptian studyHala A. Shaheen0Sayed S. Sayed1Lamiaa I. Daker2Mohamed A. Taha3Neurology Department, Faculty of Medicine Fayoum UniversityNeurology Department, Faculty of Medicine Fayoum UniversityNeurology Department, Faculty of Medicine Fayoum UniversityNeurology Department, Faculty of Medicine Fayoum UniversityAbstract Background Clinically isolated syndrome (CIS) is the first neurologic episode of multiple sclerosis (MS). Clinical presentation, neurophysiological studies, and magnetic resonance imaging (MRI) are used to predict risk of conversion to MS. There is little information regarding the risk factors of CIS conversion to MS so far in the Egyptian patients. This study aimed to evaluate the predictors of early conversion of the Egyptian patients with CIS to MS. Methods A longitudinal prospective study was conducted on 43 Egyptian patients diagnosed as CIS according to the McDonald criteria (2010). The CIS patients underwent clinical assessment of disability using Expanded Disability Status Scale(EDSS), brain imaging by magnetic resonance imaging (MRI), and visual evoked potential (VEP) at baseline and after 1-year follow-up. Results Eight patients (19.6%) with CIS converted to clinically definite MS after 1 year. A logistic regression analysis revealed that the CIS patients with initial clinical presentation with optic neuritis and higher MRI brain lesion number were associated with early conversion to MS (p = 0.003, p = 0.002, respectively). The total MRI brain T2 lesion number that predicts early conversion to MS was four lesions with sensitivity (100%) and specificity (85.7%). Conclusions The patients with CIS that early presented with optic neuritis and higher MRI brain lesion number are at higher risk for conversion to clinically definite MS.http://link.springer.com/article/10.1186/s41983-018-0021-3Clinically isolated syndromePredictors of conversionMultiple sclerosis |
| spellingShingle | Hala A. Shaheen Sayed S. Sayed Lamiaa I. Daker Mohamed A. Taha Early predictors of conversion in patients with clinically isolated syndrome: a preliminary Egyptian study The Egyptian Journal of Neurology, Psychiatry and Neurosurgery Clinically isolated syndrome Predictors of conversion Multiple sclerosis |
| title | Early predictors of conversion in patients with clinically isolated syndrome: a preliminary Egyptian study |
| title_full | Early predictors of conversion in patients with clinically isolated syndrome: a preliminary Egyptian study |
| title_fullStr | Early predictors of conversion in patients with clinically isolated syndrome: a preliminary Egyptian study |
| title_full_unstemmed | Early predictors of conversion in patients with clinically isolated syndrome: a preliminary Egyptian study |
| title_short | Early predictors of conversion in patients with clinically isolated syndrome: a preliminary Egyptian study |
| title_sort | early predictors of conversion in patients with clinically isolated syndrome a preliminary egyptian study |
| topic | Clinically isolated syndrome Predictors of conversion Multiple sclerosis |
| url | http://link.springer.com/article/10.1186/s41983-018-0021-3 |
| work_keys_str_mv | AT halaashaheen earlypredictorsofconversioninpatientswithclinicallyisolatedsyndromeapreliminaryegyptianstudy AT sayedssayed earlypredictorsofconversioninpatientswithclinicallyisolatedsyndromeapreliminaryegyptianstudy AT lamiaaidaker earlypredictorsofconversioninpatientswithclinicallyisolatedsyndromeapreliminaryegyptianstudy AT mohamedataha earlypredictorsofconversioninpatientswithclinicallyisolatedsyndromeapreliminaryegyptianstudy |