Relationship among psychotic features, benzodiazepine receptor agonists, and rehospitalization in patients with electroconvulsive therapy‐responsive major depressive disorder: A retrospective 2‐year observational study
Abstract Aim It is controversial whether psychotic features are a risk factor for relapse in patients with electroconvulsive therapy‐responsive major depressive disorder. A recent study reported that benzodiazepine receptor agonists reduce relapse of psychotic depression. As long‐term use of these a...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-12-01
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| Series: | Neuropsychopharmacology Reports |
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| Online Access: | https://doi.org/10.1002/npr2.12282 |
| _version_ | 1797979244270190592 |
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| author | Akise Umakoshi Masahiro Takeshima Yu Itoh Mari Yamamoto Nana Shibata Masaya Ogasawara Naoko Ayabe Kazuo Mishima |
| author_facet | Akise Umakoshi Masahiro Takeshima Yu Itoh Mari Yamamoto Nana Shibata Masaya Ogasawara Naoko Ayabe Kazuo Mishima |
| author_sort | Akise Umakoshi |
| collection | DOAJ |
| description | Abstract Aim It is controversial whether psychotic features are a risk factor for relapse in patients with electroconvulsive therapy‐responsive major depressive disorder. A recent study reported that benzodiazepine receptor agonists reduce relapse of psychotic depression. As long‐term use of these agonists may induce dependence, further research is required. We examined whether psychotic features are associated with rehospitalization in electroconvulsive therapy‐responsive major depressive disorder patients. We also investigated whether taking benzodiazepine receptor agonists at the end of electro‐convulsive therapy was associated with rehospitalization among patients with psychotic depression. Methods This study included 47 hospitalized patients (22 with psychotic depression, 25 with non‐psychotic depression) who had responded to electroconvulsive therapy. Rehospitalization for major depressive episodes within two years from the last session was investigated. Results Twenty‐three subjects (49%) were rehospitalized during the two‐year follow‐up. Kaplan–Meier analysis revealed no difference in rehospitalization between patients with psychotic and non‐psychotic depression (Log‐rank P = 0.87). Among the 22 responders to electroconvulsive therapy with psychotic depression, there was no difference in benzodiazepine receptor agonist use at the end of electroconvulsive therapy between the rehospitalization and non‐rehospitalization groups. Conclusion Our exploratory study found no difference in the benzodiazepine receptor agonists use at the end of electroconvulsive therapy between rehospitalization and non‐rehospitalization groups in patients with electroconvulsive therapy‐responsive psychotic depression. Thus, the relapse‐preventing effect of these agonists in psychotic depression should be investigated in future randomized controlled trials. Further research is also needed to determine whether psychotic features are associated with rehospitalization in these patients. |
| first_indexed | 2024-04-11T05:35:53Z |
| format | Article |
| id | doaj.art-7609f8fb98e14aad9a47cedb8b6545ae |
| institution | Directory Open Access Journal |
| issn | 2574-173X |
| language | English |
| last_indexed | 2024-04-11T05:35:53Z |
| publishDate | 2022-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neuropsychopharmacology Reports |
| spelling | doaj.art-7609f8fb98e14aad9a47cedb8b6545ae2022-12-22T12:22:50ZengWileyNeuropsychopharmacology Reports2574-173X2022-12-0142444945610.1002/npr2.12282Relationship among psychotic features, benzodiazepine receptor agonists, and rehospitalization in patients with electroconvulsive therapy‐responsive major depressive disorder: A retrospective 2‐year observational studyAkise Umakoshi0Masahiro Takeshima1Yu Itoh2Mari Yamamoto3Nana Shibata4Masaya Ogasawara5Naoko Ayabe6Kazuo Mishima7Department of Neuropsychiatry Akita University Graduate School of Medicine Akita JapanDepartment of Neuropsychiatry Akita University Graduate School of Medicine Akita JapanDepartment of Neuropsychiatry Akita University Graduate School of Medicine Akita JapanDepartment of Neuropsychiatry Akita University Graduate School of Medicine Akita JapanDepartment of Neuropsychiatry Akita University Graduate School of Medicine Akita JapanDepartment of Neuropsychiatry Akita University Graduate School of Medicine Akita JapanDepartment of Regional Studies and Humanities, Faculty of Education and Human Studies Akita University Akita JapanDepartment of Neuropsychiatry Akita University Graduate School of Medicine Akita JapanAbstract Aim It is controversial whether psychotic features are a risk factor for relapse in patients with electroconvulsive therapy‐responsive major depressive disorder. A recent study reported that benzodiazepine receptor agonists reduce relapse of psychotic depression. As long‐term use of these agonists may induce dependence, further research is required. We examined whether psychotic features are associated with rehospitalization in electroconvulsive therapy‐responsive major depressive disorder patients. We also investigated whether taking benzodiazepine receptor agonists at the end of electro‐convulsive therapy was associated with rehospitalization among patients with psychotic depression. Methods This study included 47 hospitalized patients (22 with psychotic depression, 25 with non‐psychotic depression) who had responded to electroconvulsive therapy. Rehospitalization for major depressive episodes within two years from the last session was investigated. Results Twenty‐three subjects (49%) were rehospitalized during the two‐year follow‐up. Kaplan–Meier analysis revealed no difference in rehospitalization between patients with psychotic and non‐psychotic depression (Log‐rank P = 0.87). Among the 22 responders to electroconvulsive therapy with psychotic depression, there was no difference in benzodiazepine receptor agonist use at the end of electroconvulsive therapy between the rehospitalization and non‐rehospitalization groups. Conclusion Our exploratory study found no difference in the benzodiazepine receptor agonists use at the end of electroconvulsive therapy between rehospitalization and non‐rehospitalization groups in patients with electroconvulsive therapy‐responsive psychotic depression. Thus, the relapse‐preventing effect of these agonists in psychotic depression should be investigated in future randomized controlled trials. Further research is also needed to determine whether psychotic features are associated with rehospitalization in these patients.https://doi.org/10.1002/npr2.12282benzodiazepinesdepressionelectroconvulsive therapypsychotic disordersrecurrence |
| spellingShingle | Akise Umakoshi Masahiro Takeshima Yu Itoh Mari Yamamoto Nana Shibata Masaya Ogasawara Naoko Ayabe Kazuo Mishima Relationship among psychotic features, benzodiazepine receptor agonists, and rehospitalization in patients with electroconvulsive therapy‐responsive major depressive disorder: A retrospective 2‐year observational study Neuropsychopharmacology Reports benzodiazepines depression electroconvulsive therapy psychotic disorders recurrence |
| title | Relationship among psychotic features, benzodiazepine receptor agonists, and rehospitalization in patients with electroconvulsive therapy‐responsive major depressive disorder: A retrospective 2‐year observational study |
| title_full | Relationship among psychotic features, benzodiazepine receptor agonists, and rehospitalization in patients with electroconvulsive therapy‐responsive major depressive disorder: A retrospective 2‐year observational study |
| title_fullStr | Relationship among psychotic features, benzodiazepine receptor agonists, and rehospitalization in patients with electroconvulsive therapy‐responsive major depressive disorder: A retrospective 2‐year observational study |
| title_full_unstemmed | Relationship among psychotic features, benzodiazepine receptor agonists, and rehospitalization in patients with electroconvulsive therapy‐responsive major depressive disorder: A retrospective 2‐year observational study |
| title_short | Relationship among psychotic features, benzodiazepine receptor agonists, and rehospitalization in patients with electroconvulsive therapy‐responsive major depressive disorder: A retrospective 2‐year observational study |
| title_sort | relationship among psychotic features benzodiazepine receptor agonists and rehospitalization in patients with electroconvulsive therapy responsive major depressive disorder a retrospective 2 year observational study |
| topic | benzodiazepines depression electroconvulsive therapy psychotic disorders recurrence |
| url | https://doi.org/10.1002/npr2.12282 |
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