Reduced Levels of Selenium and Thioredoxin Reductase in the Thoracic Aorta Could Contribute to Aneurysm Formation in Patients with Marfan Syndrome
Marfan syndrome (MFS) is an autosomal dominant disorder caused by a heterozygous mutation of the FBN1 gene. MFS patients present oxidative stress that disturbs redox homeostasis. Redox homeostasis depends in part on the enzymatic antioxidant system, which includes thioredoxin reductase (TrxR) and gl...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-06-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/13/10429 |
| _version_ | 1797591634979848192 |
|---|---|
| author | María Elena Soto Israel Pérez-Torres Linaloe Manzano-Pech Elizabeth Soria-Castro Almilcar Morales-Marín Edgar Samuel Ramírez-Marroquín Humberto Martínez-Hernández Valentín Herrera-Alarcón Verónica Guarner-Lans |
| author_facet | María Elena Soto Israel Pérez-Torres Linaloe Manzano-Pech Elizabeth Soria-Castro Almilcar Morales-Marín Edgar Samuel Ramírez-Marroquín Humberto Martínez-Hernández Valentín Herrera-Alarcón Verónica Guarner-Lans |
| author_sort | María Elena Soto |
| collection | DOAJ |
| description | Marfan syndrome (MFS) is an autosomal dominant disorder caused by a heterozygous mutation of the FBN1 gene. MFS patients present oxidative stress that disturbs redox homeostasis. Redox homeostasis depends in part on the enzymatic antioxidant system, which includes thioredoxin reductase (TrxR) and glutathione peroxidases (GPx), both of which require an adequate concentration of selenium (Se). Therefore, the aim of this study was to determine if Se levels are decreased in the TAA of patients with MFS since this could contribute to the formation of an aneurysm in these patients. The results show that interleukins IL-1β, IL-6 TGF-β1, and TNF-α (<i>p</i> ≤ 0.03), and carbonylation (<i>p</i> ≤ 0.03) were increased in the TAA of patients with MFS in comparison with control subjects, while Se, thiols (<i>p</i> = 0.02), TrxR, and GPx (<i>p</i> ≤ 0.001) were decreased. TLR4 and NOX1 (<i>p</i> ≤ 0.03), MMP9 and MMP2 (<i>p</i> = 0.04) and NOS2 (<i>p</i> < 0.001) were also increased. Therefore, Se concentrations are decreased in the TAA of MFS, which can contribute to a decrease in the activities of TrxR and GPx, and thiol groups. A decrease in the activities of these enzymes can lead to the loss of redox homeostasis, which can, in turn, lead to an increase in the pro-inflammatory interleukins associated with the overexpression of MMP9 and MMP2. |
| first_indexed | 2024-03-11T01:40:06Z |
| format | Article |
| id | doaj.art-760ce710c38847f997c8c1e612ce44ee |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T01:40:06Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-760ce710c38847f997c8c1e612ce44ee2023-11-18T16:38:02ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-06-0124131042910.3390/ijms241310429Reduced Levels of Selenium and Thioredoxin Reductase in the Thoracic Aorta Could Contribute to Aneurysm Formation in Patients with Marfan SyndromeMaría Elena Soto0Israel Pérez-Torres1Linaloe Manzano-Pech2Elizabeth Soria-Castro3Almilcar Morales-Marín4Edgar Samuel Ramírez-Marroquín5Humberto Martínez-Hernández6Valentín Herrera-Alarcón7Verónica Guarner-Lans8Department of Immunology, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano 1, Sección XVI, Tlalpan, México City 14080, MexicoDepartment of Cardiovascular Biomedicine, Instituto Nacional de Cardiología Ignacio Chávez, México City 14080, MexicoDepartment of Cardiovascular Biomedicine, Instituto Nacional de Cardiología Ignacio Chávez, México City 14080, MexicoDepartment of Cardiovascular Biomedicine, Instituto Nacional de Cardiología Ignacio Chávez, México City 14080, MexicoDeparment Cardiothoracic Surgery Instituto Nacional de Cardiología Ignacio Chávez, México City 14080, MexicoDeparment Cardiothoracic Surgery Instituto Nacional de Cardiología Ignacio Chávez, México City 14080, MexicoDeparment Cardiothoracic Surgery Instituto Nacional de Cardiología Ignacio Chávez, México City 14080, MexicoDeparment Cardiothoracic Surgery Instituto Nacional de Cardiología Ignacio Chávez, México City 14080, MexicoDepartment of Physiology, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano 1, Sección XVI, Tlalpan, México City 14080, MexicoMarfan syndrome (MFS) is an autosomal dominant disorder caused by a heterozygous mutation of the FBN1 gene. MFS patients present oxidative stress that disturbs redox homeostasis. Redox homeostasis depends in part on the enzymatic antioxidant system, which includes thioredoxin reductase (TrxR) and glutathione peroxidases (GPx), both of which require an adequate concentration of selenium (Se). Therefore, the aim of this study was to determine if Se levels are decreased in the TAA of patients with MFS since this could contribute to the formation of an aneurysm in these patients. The results show that interleukins IL-1β, IL-6 TGF-β1, and TNF-α (<i>p</i> ≤ 0.03), and carbonylation (<i>p</i> ≤ 0.03) were increased in the TAA of patients with MFS in comparison with control subjects, while Se, thiols (<i>p</i> = 0.02), TrxR, and GPx (<i>p</i> ≤ 0.001) were decreased. TLR4 and NOX1 (<i>p</i> ≤ 0.03), MMP9 and MMP2 (<i>p</i> = 0.04) and NOS2 (<i>p</i> < 0.001) were also increased. Therefore, Se concentrations are decreased in the TAA of MFS, which can contribute to a decrease in the activities of TrxR and GPx, and thiol groups. A decrease in the activities of these enzymes can lead to the loss of redox homeostasis, which can, in turn, lead to an increase in the pro-inflammatory interleukins associated with the overexpression of MMP9 and MMP2.https://www.mdpi.com/1422-0067/24/13/10429marfan syndromeseleniumthoracic aneurysmthioredoxinoxidative stress |
| spellingShingle | María Elena Soto Israel Pérez-Torres Linaloe Manzano-Pech Elizabeth Soria-Castro Almilcar Morales-Marín Edgar Samuel Ramírez-Marroquín Humberto Martínez-Hernández Valentín Herrera-Alarcón Verónica Guarner-Lans Reduced Levels of Selenium and Thioredoxin Reductase in the Thoracic Aorta Could Contribute to Aneurysm Formation in Patients with Marfan Syndrome International Journal of Molecular Sciences marfan syndrome selenium thoracic aneurysm thioredoxin oxidative stress |
| title | Reduced Levels of Selenium and Thioredoxin Reductase in the Thoracic Aorta Could Contribute to Aneurysm Formation in Patients with Marfan Syndrome |
| title_full | Reduced Levels of Selenium and Thioredoxin Reductase in the Thoracic Aorta Could Contribute to Aneurysm Formation in Patients with Marfan Syndrome |
| title_fullStr | Reduced Levels of Selenium and Thioredoxin Reductase in the Thoracic Aorta Could Contribute to Aneurysm Formation in Patients with Marfan Syndrome |
| title_full_unstemmed | Reduced Levels of Selenium and Thioredoxin Reductase in the Thoracic Aorta Could Contribute to Aneurysm Formation in Patients with Marfan Syndrome |
| title_short | Reduced Levels of Selenium and Thioredoxin Reductase in the Thoracic Aorta Could Contribute to Aneurysm Formation in Patients with Marfan Syndrome |
| title_sort | reduced levels of selenium and thioredoxin reductase in the thoracic aorta could contribute to aneurysm formation in patients with marfan syndrome |
| topic | marfan syndrome selenium thoracic aneurysm thioredoxin oxidative stress |
| url | https://www.mdpi.com/1422-0067/24/13/10429 |
| work_keys_str_mv | AT mariaelenasoto reducedlevelsofseleniumandthioredoxinreductaseinthethoracicaortacouldcontributetoaneurysmformationinpatientswithmarfansyndrome AT israelpereztorres reducedlevelsofseleniumandthioredoxinreductaseinthethoracicaortacouldcontributetoaneurysmformationinpatientswithmarfansyndrome AT linaloemanzanopech reducedlevelsofseleniumandthioredoxinreductaseinthethoracicaortacouldcontributetoaneurysmformationinpatientswithmarfansyndrome AT elizabethsoriacastro reducedlevelsofseleniumandthioredoxinreductaseinthethoracicaortacouldcontributetoaneurysmformationinpatientswithmarfansyndrome AT almilcarmoralesmarin reducedlevelsofseleniumandthioredoxinreductaseinthethoracicaortacouldcontributetoaneurysmformationinpatientswithmarfansyndrome AT edgarsamuelramirezmarroquin reducedlevelsofseleniumandthioredoxinreductaseinthethoracicaortacouldcontributetoaneurysmformationinpatientswithmarfansyndrome AT humbertomartinezhernandez reducedlevelsofseleniumandthioredoxinreductaseinthethoracicaortacouldcontributetoaneurysmformationinpatientswithmarfansyndrome AT valentinherreraalarcon reducedlevelsofseleniumandthioredoxinreductaseinthethoracicaortacouldcontributetoaneurysmformationinpatientswithmarfansyndrome AT veronicaguarnerlans reducedlevelsofseleniumandthioredoxinreductaseinthethoracicaortacouldcontributetoaneurysmformationinpatientswithmarfansyndrome |