The multi-tissue landscape of somatic mtDNA mutations indicates tissue-specific accumulation and removal in aging
Accumulation of somatic mutations in the mitochondrial genome (mtDNA) has long been proposed as a possible mechanism of mitochondrial and tissue dysfunction that occurs during aging. A thorough characterization of age-associated mtDNA somatic mutations has been hampered by the limited ability to det...
Main Authors: | Monica Sanchez-Contreras, Mariya T Sweetwyne, Kristine A Tsantilas, Jeremy A Whitson, Matthew D Campbell, Brenden F Kohrn, Hyeon Jeong Kim, Michael J Hipp, Jeanne Fredrickson, Megan M Nguyen, James B Hurley, David J Marcinek, Peter S Rabinovitch, Scott R Kennedy |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2023-02-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/83395 |
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