Geraniol Ameliorates Doxorubicin-Mediated Kidney Injury through Alteration of Antioxidant Status, Inflammation, and Apoptosis: Potential Roles of NF-κB and Nrf2/Ho-1

Geraniol Ameliorates Doxorubicin-Mediated Kidney Injury through Alteration of Antioxidant Status, Inflammation, and Apoptosis: Potential Roles of NF-κB and Nrf2/Ho-1

Doxorubicin-mediated kidney impairment is a serious problem in cancer treatment. Accordingly, this work investigated the ability of geraniol to modulate doxorubicin-induced kidney damage using a rat model. Rats were randomly assigned to four groups: control, doxorubicin (20 mg/kg, intraperitoneal, i...

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Bibliographic Details
Main Authors: Abdullah F. AlAsmari, Nemat Ali, Metab Alharbi, Faleh Alqahtani, Fawaz Alasmari, Daad Almoqbel, Mohammed AlSwayyed, Abdulrahman Alshammari, Mohammed M. Alanazi, Ali Alhoshani, Naif O. Al-Harbi
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Nutrients
Subjects:
doxorubicin
inflammation
oxidative stress
apoptosis
kidney injury
geraniol
Online Access:https://www.mdpi.com/2072-6643/14/8/1620

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