The average 30-minute post-prandial C-peptide predicted diabetic retinopathy progress: a retro-prospective study
Abstract Background The conclusion between Connecting peptide (C-peptide) and diabetic chronic complication was controversial. The purpose of this study is to explore the possible association between average C-peptide with diabetic retinopathy (DR) progression in Chinese patients with type 2 diabete...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-03-01
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| Series: | BMC Endocrine Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12902-023-01300-x |
| _version_ | 1797864499527548928 |
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| author | Ting Pan Jie Gao Xinghua Cai Huihui Zhang Jun Lu Tao Lei |
| author_facet | Ting Pan Jie Gao Xinghua Cai Huihui Zhang Jun Lu Tao Lei |
| author_sort | Ting Pan |
| collection | DOAJ |
| description | Abstract Background The conclusion between Connecting peptide (C-peptide) and diabetic chronic complication was controversial. The purpose of this study is to explore the possible association between average C-peptide with diabetic retinopathy (DR) progression in Chinese patients with type 2 diabetes. Methods This is a retro-prospective study. 622 patients with type 2 diabetes were included. DR was evaluated using non-mydriatic fundus photography and DR progression was defined as any deterioration of either eye. Fasting and postprandial c-peptide levels were assayed at baseline and follow-up period. Differences between continuous variables were compared using the Mann–Whitney U test; and categorical variables were analyzed by the chi-square test. Correlation between parameters and 30-minute postprandial C-peptide were determined by Spearman correlation test. The relationship between C-peptide and DR progression was evaluated by multivariable binary logistic regression. Two-tailed P-values < 0.05 were regarded as statistically significant. Results DR was present in 162 (26.0%) patients at baseline, and 26.4% of patients were found progression of DR at follow-up. Patients with progression of DR had lower average levels of 30-minute postprandial C-peptide (2.01 ng/ml vs. 2.6 ng/ml, p = 0.015) and 120-minute postprandial C-peptide (3.17 ng/ml vs. 3.92 ng/ml, p < 0.029), as well as average increment of 30-minute (0.41 ng/ml vs. 0.64 ng/ml, p = 0.015) and 120-minute postprandial C-peptide (1.48 ng/ml vs. 1.93 ng/ml, p < 0.017), than those without DR aggravation. Multivariate logistic regression analysis determined that 30-minute postprandial C-peptide and its increment were related to reduced odds ratios for DR progression (odds ratios [OR] = 0.83 and 0.74, respectively). Conclusion Our results suggest that the Average 30-minute post-prandial C-peptide and increment were negatively correlated with DR progression, which further demonstrates the importance to preserve β-cell residual function in the prevention for DR progression. Trial registration Not applicable. |
| first_indexed | 2024-04-09T22:52:54Z |
| format | Article |
| id | doaj.art-7612ae0286b14e19bec7d58d14f5b11f |
| institution | Directory Open Access Journal |
| issn | 1472-6823 |
| language | English |
| last_indexed | 2024-04-09T22:52:54Z |
| publishDate | 2023-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Endocrine Disorders |
| spelling | doaj.art-7612ae0286b14e19bec7d58d14f5b11f2023-03-22T11:33:37ZengBMCBMC Endocrine Disorders1472-68232023-03-012311610.1186/s12902-023-01300-xThe average 30-minute post-prandial C-peptide predicted diabetic retinopathy progress: a retro-prospective studyTing Pan0Jie Gao1Xinghua Cai2Huihui Zhang3Jun Lu4Tao Lei5School of Medical and Life Sciences, Chengdu University of Traditional Chinese MedicineDepartment of Endocrinology, Putuo Hospital, Shanghai University of Traditional Chinese MedicineShanghai Putuo Central School of Clinical Medicine, Anhui Medical UniversitySchool of Medical and Life Sciences, Chengdu University of Traditional Chinese MedicineDepartment of Endocrinology, Putuo Hospital, Shanghai University of Traditional Chinese MedicineDepartment of Endocrinology, Putuo Hospital, Shanghai University of Traditional Chinese MedicineAbstract Background The conclusion between Connecting peptide (C-peptide) and diabetic chronic complication was controversial. The purpose of this study is to explore the possible association between average C-peptide with diabetic retinopathy (DR) progression in Chinese patients with type 2 diabetes. Methods This is a retro-prospective study. 622 patients with type 2 diabetes were included. DR was evaluated using non-mydriatic fundus photography and DR progression was defined as any deterioration of either eye. Fasting and postprandial c-peptide levels were assayed at baseline and follow-up period. Differences between continuous variables were compared using the Mann–Whitney U test; and categorical variables were analyzed by the chi-square test. Correlation between parameters and 30-minute postprandial C-peptide were determined by Spearman correlation test. The relationship between C-peptide and DR progression was evaluated by multivariable binary logistic regression. Two-tailed P-values < 0.05 were regarded as statistically significant. Results DR was present in 162 (26.0%) patients at baseline, and 26.4% of patients were found progression of DR at follow-up. Patients with progression of DR had lower average levels of 30-minute postprandial C-peptide (2.01 ng/ml vs. 2.6 ng/ml, p = 0.015) and 120-minute postprandial C-peptide (3.17 ng/ml vs. 3.92 ng/ml, p < 0.029), as well as average increment of 30-minute (0.41 ng/ml vs. 0.64 ng/ml, p = 0.015) and 120-minute postprandial C-peptide (1.48 ng/ml vs. 1.93 ng/ml, p < 0.017), than those without DR aggravation. Multivariate logistic regression analysis determined that 30-minute postprandial C-peptide and its increment were related to reduced odds ratios for DR progression (odds ratios [OR] = 0.83 and 0.74, respectively). Conclusion Our results suggest that the Average 30-minute post-prandial C-peptide and increment were negatively correlated with DR progression, which further demonstrates the importance to preserve β-cell residual function in the prevention for DR progression. Trial registration Not applicable.https://doi.org/10.1186/s12902-023-01300-xC-peptideDiabetic RetinopathyType 2 diabetes Mellitus |
| spellingShingle | Ting Pan Jie Gao Xinghua Cai Huihui Zhang Jun Lu Tao Lei The average 30-minute post-prandial C-peptide predicted diabetic retinopathy progress: a retro-prospective study BMC Endocrine Disorders C-peptide Diabetic Retinopathy Type 2 diabetes Mellitus |
| title | The average 30-minute post-prandial C-peptide predicted diabetic retinopathy progress: a retro-prospective study |
| title_full | The average 30-minute post-prandial C-peptide predicted diabetic retinopathy progress: a retro-prospective study |
| title_fullStr | The average 30-minute post-prandial C-peptide predicted diabetic retinopathy progress: a retro-prospective study |
| title_full_unstemmed | The average 30-minute post-prandial C-peptide predicted diabetic retinopathy progress: a retro-prospective study |
| title_short | The average 30-minute post-prandial C-peptide predicted diabetic retinopathy progress: a retro-prospective study |
| title_sort | average 30 minute post prandial c peptide predicted diabetic retinopathy progress a retro prospective study |
| topic | C-peptide Diabetic Retinopathy Type 2 diabetes Mellitus |
| url | https://doi.org/10.1186/s12902-023-01300-x |
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