Associations between repetitive negative thinking and resting-state network segregation among healthy middle-aged adults
BackgroundRepetitive Negative Thinking (RNT) includes negative thoughts about the future and past, and is a risk factor for depression and anxiety. Prefrontal and anterior cingulate cortices have been linked to RNT but several regions within large-scale networks are also involved, the efficiency of...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2022.1062887/full |
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| author | Cristina Solé-Padullés Cristina Solé-Padullés Gabriele Cattaneo Natalie L. Marchant María Cabello-Toscano María Cabello-Toscano Lídia Mulet-Pons Lídia Mulet-Pons Javier Solana Núria Bargalló Josep M. Tormos Álvaro Pascual-Leone Álvaro Pascual-Leone David Bartrés-Faz David Bartrés-Faz David Bartrés-Faz |
| author_facet | Cristina Solé-Padullés Cristina Solé-Padullés Gabriele Cattaneo Natalie L. Marchant María Cabello-Toscano María Cabello-Toscano Lídia Mulet-Pons Lídia Mulet-Pons Javier Solana Núria Bargalló Josep M. Tormos Álvaro Pascual-Leone Álvaro Pascual-Leone David Bartrés-Faz David Bartrés-Faz David Bartrés-Faz |
| author_sort | Cristina Solé-Padullés |
| collection | DOAJ |
| description | BackgroundRepetitive Negative Thinking (RNT) includes negative thoughts about the future and past, and is a risk factor for depression and anxiety. Prefrontal and anterior cingulate cortices have been linked to RNT but several regions within large-scale networks are also involved, the efficiency of which depends on their ability to remain segregated.MethodsAssociations between RNT and system segregation (SyS) of the Anterior Salience Network (ASN), Default Mode Network (DMN) and Executive Control Network (ECN) were explored in healthy middle-aged adults (N = 341), after undergoing resting-state functional magnetic resonance imaging. Regression analyses were conducted with RNT as outcome variable. Explanatory variables were: SyS, depression, emotional stability, cognitive complaints, age and sex.ResultsAnalyses indicated that RNT was associated with depression, emotional stability, cognitive complaints, age and segregation of the left ECN (LECN) and ASN. Further, the ventral DMN (vDMN) presented higher connectivity with the ASN and decreased connectivity with the LECN, as a function of RNT.ConclusionHigher levels of perseverative thinking were related to increased segregation of the LECN and decreased segregation of the ASN. The dissociative connectivity of these networks with the vDMN may partially account for poorer cognitive control and increased self-referential processes characteristic of RNT. |
| first_indexed | 2024-04-11T13:06:07Z |
| format | Article |
| id | doaj.art-761322c0b0b5450486bc73fca234a642 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-04-11T13:06:07Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-761322c0b0b5450486bc73fca234a6422022-12-22T04:22:45ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652022-12-011410.3389/fnagi.2022.10628871062887Associations between repetitive negative thinking and resting-state network segregation among healthy middle-aged adultsCristina Solé-Padullés0Cristina Solé-Padullés1Gabriele Cattaneo2Natalie L. Marchant3María Cabello-Toscano4María Cabello-Toscano5Lídia Mulet-Pons6Lídia Mulet-Pons7Javier Solana8Núria Bargalló9Josep M. Tormos10Álvaro Pascual-Leone11Álvaro Pascual-Leone12David Bartrés-Faz13David Bartrés-Faz14David Bartrés-Faz15Department of Medicine, Faculty of Medicine and Health Sciences; Institute of Neurosciences, University of Barcelona, Barcelona, SpainInstitut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, SpainInstitut Guttmann, Institut Universitari de Neurorehabilitació adscrit a la UAB, Barcelona, SpainDivision of Psychiatry, University College London, London, United KingdomDepartment of Medicine, Faculty of Medicine and Health Sciences; Institute of Neurosciences, University of Barcelona, Barcelona, SpainInstitut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, SpainDepartment of Medicine, Faculty of Medicine and Health Sciences; Institute of Neurosciences, University of Barcelona, Barcelona, SpainInstitut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, SpainInstitut Guttmann, Institut Universitari de Neurorehabilitació adscrit a la UAB, Barcelona, SpainMagnetic Resonance Image Core Facility, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, SpainInstitut Guttmann, Institut Universitari de Neurorehabilitació adscrit a la UAB, Barcelona, SpainMagnetic Resonance Image Core Facility, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, SpainHinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Harvard Medical School, Boston, MA, United StatesDepartment of Medicine, Faculty of Medicine and Health Sciences; Institute of Neurosciences, University of Barcelona, Barcelona, SpainInstitut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, SpainInstitut Guttmann, Institut Universitari de Neurorehabilitació adscrit a la UAB, Barcelona, SpainBackgroundRepetitive Negative Thinking (RNT) includes negative thoughts about the future and past, and is a risk factor for depression and anxiety. Prefrontal and anterior cingulate cortices have been linked to RNT but several regions within large-scale networks are also involved, the efficiency of which depends on their ability to remain segregated.MethodsAssociations between RNT and system segregation (SyS) of the Anterior Salience Network (ASN), Default Mode Network (DMN) and Executive Control Network (ECN) were explored in healthy middle-aged adults (N = 341), after undergoing resting-state functional magnetic resonance imaging. Regression analyses were conducted with RNT as outcome variable. Explanatory variables were: SyS, depression, emotional stability, cognitive complaints, age and sex.ResultsAnalyses indicated that RNT was associated with depression, emotional stability, cognitive complaints, age and segregation of the left ECN (LECN) and ASN. Further, the ventral DMN (vDMN) presented higher connectivity with the ASN and decreased connectivity with the LECN, as a function of RNT.ConclusionHigher levels of perseverative thinking were related to increased segregation of the LECN and decreased segregation of the ASN. The dissociative connectivity of these networks with the vDMN may partially account for poorer cognitive control and increased self-referential processes characteristic of RNT.https://www.frontiersin.org/articles/10.3389/fnagi.2022.1062887/fullrepetitive negative thinkingresting-state networkssystem segregationdepressionanxietyrumination |
| spellingShingle | Cristina Solé-Padullés Cristina Solé-Padullés Gabriele Cattaneo Natalie L. Marchant María Cabello-Toscano María Cabello-Toscano Lídia Mulet-Pons Lídia Mulet-Pons Javier Solana Núria Bargalló Josep M. Tormos Álvaro Pascual-Leone Álvaro Pascual-Leone David Bartrés-Faz David Bartrés-Faz David Bartrés-Faz Associations between repetitive negative thinking and resting-state network segregation among healthy middle-aged adults Frontiers in Aging Neuroscience repetitive negative thinking resting-state networks system segregation depression anxiety rumination |
| title | Associations between repetitive negative thinking and resting-state network segregation among healthy middle-aged adults |
| title_full | Associations between repetitive negative thinking and resting-state network segregation among healthy middle-aged adults |
| title_fullStr | Associations between repetitive negative thinking and resting-state network segregation among healthy middle-aged adults |
| title_full_unstemmed | Associations between repetitive negative thinking and resting-state network segregation among healthy middle-aged adults |
| title_short | Associations between repetitive negative thinking and resting-state network segregation among healthy middle-aged adults |
| title_sort | associations between repetitive negative thinking and resting state network segregation among healthy middle aged adults |
| topic | repetitive negative thinking resting-state networks system segregation depression anxiety rumination |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2022.1062887/full |
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