Preclinical Models of Pancreatic Ductal Adenocarcinoma and Their Utility in Immunotherapy Studies

Preclinical Models of Pancreatic Ductal Adenocarcinoma and Their Utility in Immunotherapy Studies

The advent of immunotherapy has transformed the treatment landscape for several human malignancies. Antibodies against immune checkpoints, such as anti-PD-1/PD-L1 and anti-CTLA-4, demonstrate durable clinical benefits in several cancer types. However, checkpoint blockade has failed to elicit effecti...

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Bibliographic Details
Main Authors: Thao N. D. Pham, Mario A. Shields, Christina Spaulding, Daniel R. Principe, Bo Li, Patrick W. Underwood, Jose G. Trevino, David J. Bentrem, Hidayatullah G. Munshi
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Cancers
Subjects:
immunotherapy
pancreatic cancer
murine models
genetically-engineered mouse models
patient-derived xenografts
organoids
Online Access:https://www.mdpi.com/2072-6694/13/3/440

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