A Cross-Sectional Study of Oral Lichen Planus Associated With Thyroid Diseases in East China
Objective: To investigate the prevalence of thyroid diseases in patients with oral lichen planus (OLP) and to explore the correlation between the two diseases.Methods: A cross-sectional study was conducted to investigate the history of thyroid disease in 585 patients with oral lichen planus diagnose...
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Frontiers Media S.A.
2020-01-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fendo.2019.00928/full |
| _version_ | 1818176877471203328 |
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| author | Yunju Tang Yunju Tang Linjun Shi Linjun Shi Boren Jiang Zengtong Zhou Zengtong Zhou Xuemin Shen Xuemin Shen |
| author_facet | Yunju Tang Yunju Tang Linjun Shi Linjun Shi Boren Jiang Zengtong Zhou Zengtong Zhou Xuemin Shen Xuemin Shen |
| author_sort | Yunju Tang |
| collection | DOAJ |
| description | Objective: To investigate the prevalence of thyroid diseases in patients with oral lichen planus (OLP) and to explore the correlation between the two diseases.Methods: A cross-sectional study was conducted to investigate the history of thyroid disease in 585 patients with oral lichen planus diagnosed in the Department of Oral Mucosal Diseases of the Ninth People's Hospital, Shanghai Jiaotong University, School of Medicine from June 2017 to April 2018 and in 10,441 normal people in an epidemiological survey conducted by endocrinology department of Ninth People's Hospitalin eastern China from 2014 to 2015. Personal medical history of thyroid disease was obtained through questionnaire and thyroid function was also tested.Results: Of the 585 patients with OLP, 190 (32.48%) had thyroid disease (excluding coexistence of multiple thyroid diseases), 62 (32.6%) had thyroid nodules, and 71 (37.4%) had Hashimoto's thyroiditis. Hyperthyroidism was diagnosed in six patients (3.2%), hypothyroidism in seven patients (3.7%), and thyroid cancer in 11 patients (5.8%). The prevalence of Hashimoto's thyroiditis was significantly higher in patients with oral lichen planus than in the general population. The probability of thyroid disease was significantly higher in women with OLP than in men with OLP (P < 0.001).Conclusion: OLP is associated with a high probability of developing thyroid disease, especially Hashimoto's thyroiditis. In the management of OLP patients, especially in female patients, thyroid disease must be screened. |
| first_indexed | 2024-12-11T20:23:10Z |
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| id | doaj.art-7614b4b5a5c84a259bb472ec7281dc11 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-11T20:23:10Z |
| publishDate | 2020-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-7614b4b5a5c84a259bb472ec7281dc112022-12-22T00:52:01ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922020-01-011010.3389/fendo.2019.00928500510A Cross-Sectional Study of Oral Lichen Planus Associated With Thyroid Diseases in East ChinaYunju Tang0Yunju Tang1Linjun Shi2Linjun Shi3Boren Jiang4Zengtong Zhou5Zengtong Zhou6Xuemin Shen7Xuemin Shen8Department of Oral Mucosal Diseases, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaNational Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai, ChinaDepartment of Oral Mucosal Diseases, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaNational Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai, ChinaDepartment of Endocrinology and Metabolism, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Oral Mucosal Diseases, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaNational Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai, ChinaDepartment of Oral Mucosal Diseases, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaNational Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai, ChinaObjective: To investigate the prevalence of thyroid diseases in patients with oral lichen planus (OLP) and to explore the correlation between the two diseases.Methods: A cross-sectional study was conducted to investigate the history of thyroid disease in 585 patients with oral lichen planus diagnosed in the Department of Oral Mucosal Diseases of the Ninth People's Hospital, Shanghai Jiaotong University, School of Medicine from June 2017 to April 2018 and in 10,441 normal people in an epidemiological survey conducted by endocrinology department of Ninth People's Hospitalin eastern China from 2014 to 2015. Personal medical history of thyroid disease was obtained through questionnaire and thyroid function was also tested.Results: Of the 585 patients with OLP, 190 (32.48%) had thyroid disease (excluding coexistence of multiple thyroid diseases), 62 (32.6%) had thyroid nodules, and 71 (37.4%) had Hashimoto's thyroiditis. Hyperthyroidism was diagnosed in six patients (3.2%), hypothyroidism in seven patients (3.7%), and thyroid cancer in 11 patients (5.8%). The prevalence of Hashimoto's thyroiditis was significantly higher in patients with oral lichen planus than in the general population. The probability of thyroid disease was significantly higher in women with OLP than in men with OLP (P < 0.001).Conclusion: OLP is associated with a high probability of developing thyroid disease, especially Hashimoto's thyroiditis. In the management of OLP patients, especially in female patients, thyroid disease must be screened.https://www.frontiersin.org/article/10.3389/fendo.2019.00928/fulloral lichen planusthyroid diseaseHashimoto's thyroiditisimmunologycross-sectional study |
| spellingShingle | Yunju Tang Yunju Tang Linjun Shi Linjun Shi Boren Jiang Zengtong Zhou Zengtong Zhou Xuemin Shen Xuemin Shen A Cross-Sectional Study of Oral Lichen Planus Associated With Thyroid Diseases in East China Frontiers in Endocrinology oral lichen planus thyroid disease Hashimoto's thyroiditis immunology cross-sectional study |
| title | A Cross-Sectional Study of Oral Lichen Planus Associated With Thyroid Diseases in East China |
| title_full | A Cross-Sectional Study of Oral Lichen Planus Associated With Thyroid Diseases in East China |
| title_fullStr | A Cross-Sectional Study of Oral Lichen Planus Associated With Thyroid Diseases in East China |
| title_full_unstemmed | A Cross-Sectional Study of Oral Lichen Planus Associated With Thyroid Diseases in East China |
| title_short | A Cross-Sectional Study of Oral Lichen Planus Associated With Thyroid Diseases in East China |
| title_sort | cross sectional study of oral lichen planus associated with thyroid diseases in east china |
| topic | oral lichen planus thyroid disease Hashimoto's thyroiditis immunology cross-sectional study |
| url | https://www.frontiersin.org/article/10.3389/fendo.2019.00928/full |
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