Multiple CRF01_AE/CRF07_BC Recombinants Enhanced the HIV-1 Epidemic Complexity Among MSM in Shenyang City, Northeast China
The transmission of Unique Recombinant Forms (URFs) has complicated the molecular epidemic of HIV-1. This increasing genetic diversity has implications for prevention surveillance, diagnosis, and vaccine design. In this study, we characterized the HIV-1 URFs from 135 newly diagnosed HIV-1 infected c...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2022.855049/full |
| _version_ | 1818554566164086784 |
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| author | Shan He Shan He Shan He Wei Song Gang Guo Qiang Li Minghui An Minghui An Minghui An Bin Zhao Bin Zhao Bin Zhao Yang Gao Yang Gao Yang Gao Wen Tian Wen Tian Wen Tian Lin Wang Lin Wang Lin Wang Hong Shang Hong Shang Hong Shang Xiaoxu Han Xiaoxu Han Xiaoxu Han |
| author_facet | Shan He Shan He Shan He Wei Song Gang Guo Qiang Li Minghui An Minghui An Minghui An Bin Zhao Bin Zhao Bin Zhao Yang Gao Yang Gao Yang Gao Wen Tian Wen Tian Wen Tian Lin Wang Lin Wang Lin Wang Hong Shang Hong Shang Hong Shang Xiaoxu Han Xiaoxu Han Xiaoxu Han |
| author_sort | Shan He |
| collection | DOAJ |
| description | The transmission of Unique Recombinant Forms (URFs) has complicated the molecular epidemic of HIV-1. This increasing genetic diversity has implications for prevention surveillance, diagnosis, and vaccine design. In this study, we characterized the HIV-1 URFs from 135 newly diagnosed HIV-1 infected cases between 2016 and 2020 in Shenyang, northeast China and analyzed the evolutionary relationship of them by phylogenetic and recombination approaches. Among 135 URFs, we found that the CRF01_AE/CRF07_BC recombinants were the most common (81.5%, 110/135), followed by CRF01_AE/B (11.9%, 16/135), B/C (3.7%, 5/135), and others (3.0%, 4/135). 94.8% (128/135) of patients infected by URFs were through homosexual contact. Among 110 URFs_0107, 60 (54.5%) formed 11 subclusters (branch support value = 1) and shared the consistent recombination structure, respectively. Four subclusters have caused small-scale spread among different high-risk populations. Although the recombination structures of URFs_0107 are various, the hotspots of recombinants gathered between position 2,508 and 2,627 (relative to the HXB2 position). Moreover, the CRF07_BC and CRF01AE fragments of URFs_0107 were mainly derived from the MSM population. In brief, our results reveal the complex recombinant modes and the high transmission risk of URFs_0107, which calls for more attention on the new URFs_0107 monitoring and strict control in the areas led by homosexual transmission route. |
| first_indexed | 2024-12-12T09:41:35Z |
| format | Article |
| id | doaj.art-7616907848074fb6ac428bddb0a40e72 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-12T09:41:35Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-7616907848074fb6ac428bddb0a40e722022-12-22T00:28:32ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2022-05-011310.3389/fmicb.2022.855049855049Multiple CRF01_AE/CRF07_BC Recombinants Enhanced the HIV-1 Epidemic Complexity Among MSM in Shenyang City, Northeast ChinaShan He0Shan He1Shan He2Wei Song3Gang Guo4Qiang Li5Minghui An6Minghui An7Minghui An8Bin Zhao9Bin Zhao10Bin Zhao11Yang Gao12Yang Gao13Yang Gao14Wen Tian15Wen Tian16Wen Tian17Lin Wang18Lin Wang19Lin Wang20Hong Shang21Hong Shang22Hong Shang23Xiaoxu Han24Xiaoxu Han25Xiaoxu Han26NHC Key Laboratory of AIDS Immunology (China Medical University), National Clinical Research Center for Laboratory Medicine, The First Affiliated Hospital of China Medical University, Shenyang, ChinaChinese Academy of Medical Sciences Research Unit (No. 2019RU017), China Medical University, Shenyang, ChinaKey Laboratory of AIDS Immunology of Liaoning Province, Shenyang, ChinaDepartment of Food Safety and Nutrition, Shenyang Center for Health Service and Administrative Law Enforcement (Shenyang Center for Disease Control and Prevention), Shenyang, ChinaDepartment of Clinical Laboratory, The Sixth People’s Hospital of Shenyang, Shenyang, ChinaDepartment of Clinical Laboratory, The Sixth People’s Hospital of Shenyang, Shenyang, ChinaNHC Key Laboratory of AIDS Immunology (China Medical University), National Clinical Research Center for Laboratory Medicine, The First Affiliated Hospital of China Medical University, Shenyang, ChinaChinese Academy of Medical Sciences Research Unit (No. 2019RU017), China Medical University, Shenyang, ChinaKey Laboratory of AIDS Immunology of Liaoning Province, Shenyang, ChinaNHC Key Laboratory of AIDS Immunology (China Medical University), National Clinical Research Center for Laboratory Medicine, The First Affiliated Hospital of China Medical University, Shenyang, ChinaChinese Academy of Medical Sciences Research Unit (No. 2019RU017), China Medical University, Shenyang, ChinaKey Laboratory of AIDS Immunology of Liaoning Province, Shenyang, ChinaNHC Key Laboratory of AIDS Immunology (China Medical University), National Clinical Research Center for Laboratory Medicine, The First Affiliated Hospital of China Medical University, Shenyang, ChinaChinese Academy of Medical Sciences Research Unit (No. 2019RU017), China Medical University, Shenyang, ChinaKey Laboratory of AIDS Immunology of Liaoning Province, Shenyang, ChinaNHC Key Laboratory of AIDS Immunology (China Medical University), National Clinical Research Center for Laboratory Medicine, The First Affiliated Hospital of China Medical University, Shenyang, ChinaChinese Academy of Medical Sciences Research Unit (No. 2019RU017), China Medical University, Shenyang, ChinaKey Laboratory of AIDS Immunology of Liaoning Province, Shenyang, ChinaNHC Key Laboratory of AIDS Immunology (China Medical University), National Clinical Research Center for Laboratory Medicine, The First Affiliated Hospital of China Medical University, Shenyang, ChinaChinese Academy of Medical Sciences Research Unit (No. 2019RU017), China Medical University, Shenyang, ChinaKey Laboratory of AIDS Immunology of Liaoning Province, Shenyang, ChinaNHC Key Laboratory of AIDS Immunology (China Medical University), National Clinical Research Center for Laboratory Medicine, The First Affiliated Hospital of China Medical University, Shenyang, ChinaChinese Academy of Medical Sciences Research Unit (No. 2019RU017), China Medical University, Shenyang, ChinaKey Laboratory of AIDS Immunology of Liaoning Province, Shenyang, ChinaNHC Key Laboratory of AIDS Immunology (China Medical University), National Clinical Research Center for Laboratory Medicine, The First Affiliated Hospital of China Medical University, Shenyang, ChinaChinese Academy of Medical Sciences Research Unit (No. 2019RU017), China Medical University, Shenyang, ChinaKey Laboratory of AIDS Immunology of Liaoning Province, Shenyang, ChinaThe transmission of Unique Recombinant Forms (URFs) has complicated the molecular epidemic of HIV-1. This increasing genetic diversity has implications for prevention surveillance, diagnosis, and vaccine design. In this study, we characterized the HIV-1 URFs from 135 newly diagnosed HIV-1 infected cases between 2016 and 2020 in Shenyang, northeast China and analyzed the evolutionary relationship of them by phylogenetic and recombination approaches. Among 135 URFs, we found that the CRF01_AE/CRF07_BC recombinants were the most common (81.5%, 110/135), followed by CRF01_AE/B (11.9%, 16/135), B/C (3.7%, 5/135), and others (3.0%, 4/135). 94.8% (128/135) of patients infected by URFs were through homosexual contact. Among 110 URFs_0107, 60 (54.5%) formed 11 subclusters (branch support value = 1) and shared the consistent recombination structure, respectively. Four subclusters have caused small-scale spread among different high-risk populations. Although the recombination structures of URFs_0107 are various, the hotspots of recombinants gathered between position 2,508 and 2,627 (relative to the HXB2 position). Moreover, the CRF07_BC and CRF01AE fragments of URFs_0107 were mainly derived from the MSM population. In brief, our results reveal the complex recombinant modes and the high transmission risk of URFs_0107, which calls for more attention on the new URFs_0107 monitoring and strict control in the areas led by homosexual transmission route.https://www.frontiersin.org/articles/10.3389/fmicb.2022.855049/fullHIV-1men who have sex with menunique recombinant formstransmissionphylogenetics |
| spellingShingle | Shan He Shan He Shan He Wei Song Gang Guo Qiang Li Minghui An Minghui An Minghui An Bin Zhao Bin Zhao Bin Zhao Yang Gao Yang Gao Yang Gao Wen Tian Wen Tian Wen Tian Lin Wang Lin Wang Lin Wang Hong Shang Hong Shang Hong Shang Xiaoxu Han Xiaoxu Han Xiaoxu Han Multiple CRF01_AE/CRF07_BC Recombinants Enhanced the HIV-1 Epidemic Complexity Among MSM in Shenyang City, Northeast China Frontiers in Microbiology HIV-1 men who have sex with men unique recombinant forms transmission phylogenetics |
| title | Multiple CRF01_AE/CRF07_BC Recombinants Enhanced the HIV-1 Epidemic Complexity Among MSM in Shenyang City, Northeast China |
| title_full | Multiple CRF01_AE/CRF07_BC Recombinants Enhanced the HIV-1 Epidemic Complexity Among MSM in Shenyang City, Northeast China |
| title_fullStr | Multiple CRF01_AE/CRF07_BC Recombinants Enhanced the HIV-1 Epidemic Complexity Among MSM in Shenyang City, Northeast China |
| title_full_unstemmed | Multiple CRF01_AE/CRF07_BC Recombinants Enhanced the HIV-1 Epidemic Complexity Among MSM in Shenyang City, Northeast China |
| title_short | Multiple CRF01_AE/CRF07_BC Recombinants Enhanced the HIV-1 Epidemic Complexity Among MSM in Shenyang City, Northeast China |
| title_sort | multiple crf01 ae crf07 bc recombinants enhanced the hiv 1 epidemic complexity among msm in shenyang city northeast china |
| topic | HIV-1 men who have sex with men unique recombinant forms transmission phylogenetics |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2022.855049/full |
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