Anti-inflammatory role of fenofibrate in treating diseases
Inflammation contributes to the pathogenesis of several diseases. Fenofibrate, known as a peroxisome proliferator-activated receptor - α (PPAR-α) agonist, is a classic drug for treating hyperlipidemia. In addition to its lipid-lowering effect, fenofibrate has also been reported to exert anti-inflam...
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| 格式: | 文件 |
| 语言: | English |
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Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
2023-05-01
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| 丛编: | Biomolecules & Biomedicine |
| 主题: | |
| 在线阅读: | https://www.bjbms.org/ojs/index.php/bjbms/article/view/8534 |
| _version_ | 1827317517193838592 |
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| author | Lv Jin Hu Hua Yong Ji Zhanjun Jia Mingqi Peng Songming Huang |
| author_facet | Lv Jin Hu Hua Yong Ji Zhanjun Jia Mingqi Peng Songming Huang |
| author_sort | Lv Jin |
| collection | DOAJ |
| description |
Inflammation contributes to the pathogenesis of several diseases. Fenofibrate, known as a peroxisome proliferator-activated receptor - α (PPAR-α) agonist, is a classic drug for treating hyperlipidemia. In addition to its lipid-lowering effect, fenofibrate has also been reported to exert anti-inflammatory effects with complicated underlying mechanisms of action. In general, the anti-inflammatory effect of fenofibrate is secondary to its lipid-lowering effect, especially for the inflammation caused by hyperlipidemia in the circulatory system. Some anti-inflammatory actions may also come from its regulatory effects on intracellular lipid metabolism by activating PPAR-α. In addition, some roles in anti-inflammation might be mediated by its direct regulation of inflammatory signaling pathways. In order to understand anti-inflammatory activities and the underlying mechanisms of fenofibrate action in disease better, we herein reviewed and discussed the anti-inflammatory roles and its subserving mechanisms in various diseases of different organ systems. Thus, this review offers insights into the optimal use of fenofibrate in the clinical setting.
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| first_indexed | 2024-04-24T23:40:09Z |
| format | Article |
| id | doaj.art-7616ac6f1be242debc74045f97944343 |
| institution | Directory Open Access Journal |
| issn | 2831-0896 2831-090X |
| language | English |
| last_indexed | 2024-04-24T23:40:09Z |
| publishDate | 2023-05-01 |
| publisher | Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina |
| record_format | Article |
| series | Biomolecules & Biomedicine |
| spelling | doaj.art-7616ac6f1be242debc74045f979443432024-03-15T13:22:35ZengAssociation of Basic Medical Sciences of Federation of Bosnia and HerzegovinaBiomolecules & Biomedicine2831-08962831-090X2023-05-0123310.17305/bb.2022.8534Anti-inflammatory role of fenofibrate in treating diseasesLv Jin0Hu Hua1Yong Ji2Zhanjun Jia3Mingqi Peng4Songming Huang5Department of Nephrology, Children’s Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Nephrology, Children’s Hospital of Nanjing Medical University, Nanjing, China; Nanjing Key Laboratory of Pediatrics, Children’s Hospital of Nanjing Medical University, Nanjing, China; Jiangsu Key Laboratory of Pediatrics, Nanjing Medical University, Nanjing, ChinaDepartment of Nephrology, Children’s Hospital of Nanjing Medical University, Nanjing, China; Nanjing Key Laboratory of Pediatrics, Children’s Hospital of Nanjing Medical University, Nanjing, China; Jiangsu Key Laboratory of Pediatrics, Nanjing Medical University, Nanjing, ChinaDepartment of Nephrology, Children’s Hospital of Nanjing Medical University, 72 Guangzhou Road, Nanjing 210008, China; Nanjing Key Laboratory of Pediatrics, Children’s Hospital of Nanjing Medical University, Nanjing, China; Jiangsu Key Laboratory of Pediatrics, Nanjing Medical University, Nanjing, ChinaNursing Department, Children’s Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Nephrology, Children’s Hospital of Nanjing Medical University, Nanjing, China; Nanjing Key Laboratory of Pediatrics, Children’s Hospital of Nanjing Medical University, Nanjing, China; Jiangsu Key Laboratory of Pediatrics, Nanjing Medical University, Nanjing, China Inflammation contributes to the pathogenesis of several diseases. Fenofibrate, known as a peroxisome proliferator-activated receptor - α (PPAR-α) agonist, is a classic drug for treating hyperlipidemia. In addition to its lipid-lowering effect, fenofibrate has also been reported to exert anti-inflammatory effects with complicated underlying mechanisms of action. In general, the anti-inflammatory effect of fenofibrate is secondary to its lipid-lowering effect, especially for the inflammation caused by hyperlipidemia in the circulatory system. Some anti-inflammatory actions may also come from its regulatory effects on intracellular lipid metabolism by activating PPAR-α. In addition, some roles in anti-inflammation might be mediated by its direct regulation of inflammatory signaling pathways. In order to understand anti-inflammatory activities and the underlying mechanisms of fenofibrate action in disease better, we herein reviewed and discussed the anti-inflammatory roles and its subserving mechanisms in various diseases of different organ systems. Thus, this review offers insights into the optimal use of fenofibrate in the clinical setting. https://www.bjbms.org/ojs/index.php/bjbms/article/view/8534FenofibrateinflammationmechanismPPAR-αdiseasestherapy |
| spellingShingle | Lv Jin Hu Hua Yong Ji Zhanjun Jia Mingqi Peng Songming Huang Anti-inflammatory role of fenofibrate in treating diseases Biomolecules & Biomedicine Fenofibrate inflammation mechanism PPAR-α diseases therapy |
| title | Anti-inflammatory role of fenofibrate in treating diseases |
| title_full | Anti-inflammatory role of fenofibrate in treating diseases |
| title_fullStr | Anti-inflammatory role of fenofibrate in treating diseases |
| title_full_unstemmed | Anti-inflammatory role of fenofibrate in treating diseases |
| title_short | Anti-inflammatory role of fenofibrate in treating diseases |
| title_sort | anti inflammatory role of fenofibrate in treating diseases |
| topic | Fenofibrate inflammation mechanism PPAR-α diseases therapy |
| url | https://www.bjbms.org/ojs/index.php/bjbms/article/view/8534 |
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