Diagnostic comparison of vibration-controlled transient elastography and MRI techniques in overweight and obese patients with NAFLD
Abstract Non-invasive imaging techniques have greatly advanced the assessment of liver fibrosis and steatosis but are not fully evaluated in overweight patients. We evaluated the diagnostic performance of vibration-controlled transient elastography (VCTE) and magnetic resonance elastography (MRE) to...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-12-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-25843-6 |
| _version_ | 1797977475983081472 |
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| author | Asako Nogami Masato Yoneda Michihiro Iwaki Takashi Kobayashi Takaomi Kessoku Yasushi Honda Yuji Ogawa Kento Imajo Takuma Higurashi Kunihiro Hosono Hiroyuki Kirikoshi Satoru Saito Atsushi Nakajima |
| author_facet | Asako Nogami Masato Yoneda Michihiro Iwaki Takashi Kobayashi Takaomi Kessoku Yasushi Honda Yuji Ogawa Kento Imajo Takuma Higurashi Kunihiro Hosono Hiroyuki Kirikoshi Satoru Saito Atsushi Nakajima |
| author_sort | Asako Nogami |
| collection | DOAJ |
| description | Abstract Non-invasive imaging techniques have greatly advanced the assessment of liver fibrosis and steatosis but are not fully evaluated in overweight patients. We evaluated the diagnostic performance of vibration-controlled transient elastography (VCTE) and magnetic resonance elastography (MRE) to assess fibrosis and controlled attenuation parameter (CAP) and MR imaging (MRI)-proton density fat fraction (MRI-PDFF) to assess steatosis in overweight and obese patients with non-alcoholic fatty liver disease (NAFLD). We included 163 biopsy-proven patients with NAFLD who underwent VCTE, MRE/MRI-PDFF, and liver biopsy (years 2014–2020) who were classified according to their body mass index (BMI) as normal (BMI < 25 kg/m2, n = 38), overweight (25 ≤ BMI < 30 kg/m2, n = 68), and obese (BMI ≥ 30 kg/m2, n = 57). VCTE and MRE detected fibrosis of stages ≥ 2, ≥ 3, and 4 with an area under the receiver operating curve (AUROC) of 0.83–0.94 (VCTE) and 0.85–0.95 (MRE) in all groups, without considerable differences. MRI-PDFF detected steatosis of grades ≥ 2 and 3 with high AUROC in all groups (0.81–1.00). CAP’s diagnostic ability (0.63–0.95) was lower than that of MRI-PDFF and decreased with increasing BMI compared to MRI-PDFF. VCTE and MRE similarly accurately assess fibrosis, although MRI-PDFF is more accurate than CAP in detecting steatosis in overweight and obese patients with NAFLD. |
| first_indexed | 2024-04-11T05:07:32Z |
| format | Article |
| id | doaj.art-76183c0d33dd4b398e8a4f7676698bf5 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-11T05:07:32Z |
| publishDate | 2022-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-76183c0d33dd4b398e8a4f7676698bf52022-12-25T12:14:38ZengNature PortfolioScientific Reports2045-23222022-12-0112111010.1038/s41598-022-25843-6Diagnostic comparison of vibration-controlled transient elastography and MRI techniques in overweight and obese patients with NAFLDAsako Nogami0Masato Yoneda1Michihiro Iwaki2Takashi Kobayashi3Takaomi Kessoku4Yasushi Honda5Yuji Ogawa6Kento Imajo7Takuma Higurashi8Kunihiro Hosono9Hiroyuki Kirikoshi10Satoru Saito11Atsushi Nakajima12Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of MedicineDepartment of Gastroenterology and Hepatology, Yokohama City University Graduate School of MedicineDepartment of Gastroenterology and Hepatology, Yokohama City University Graduate School of MedicineDepartment of Gastroenterology and Hepatology, Yokohama City University Graduate School of MedicineDepartment of Gastroenterology and Hepatology, Yokohama City University Graduate School of MedicineDepartment of Gastroenterology and Hepatology, Yokohama City University Graduate School of MedicineDepartment of Gastroenterology and Hepatology, Yokohama City University Graduate School of MedicineDepartment of Gastroenterology and Hepatology, Yokohama City University Graduate School of MedicineDepartment of Gastroenterology and Hepatology, Yokohama City University Graduate School of MedicineDepartment of Gastroenterology and Hepatology, Yokohama City University Graduate School of MedicineClinical Laboratory Department, Yokohama City University HospitalDepartment of Gastroenterology and Hepatology, Yokohama City University Graduate School of MedicineDepartment of Gastroenterology and Hepatology, Yokohama City University Graduate School of MedicineAbstract Non-invasive imaging techniques have greatly advanced the assessment of liver fibrosis and steatosis but are not fully evaluated in overweight patients. We evaluated the diagnostic performance of vibration-controlled transient elastography (VCTE) and magnetic resonance elastography (MRE) to assess fibrosis and controlled attenuation parameter (CAP) and MR imaging (MRI)-proton density fat fraction (MRI-PDFF) to assess steatosis in overweight and obese patients with non-alcoholic fatty liver disease (NAFLD). We included 163 biopsy-proven patients with NAFLD who underwent VCTE, MRE/MRI-PDFF, and liver biopsy (years 2014–2020) who were classified according to their body mass index (BMI) as normal (BMI < 25 kg/m2, n = 38), overweight (25 ≤ BMI < 30 kg/m2, n = 68), and obese (BMI ≥ 30 kg/m2, n = 57). VCTE and MRE detected fibrosis of stages ≥ 2, ≥ 3, and 4 with an area under the receiver operating curve (AUROC) of 0.83–0.94 (VCTE) and 0.85–0.95 (MRE) in all groups, without considerable differences. MRI-PDFF detected steatosis of grades ≥ 2 and 3 with high AUROC in all groups (0.81–1.00). CAP’s diagnostic ability (0.63–0.95) was lower than that of MRI-PDFF and decreased with increasing BMI compared to MRI-PDFF. VCTE and MRE similarly accurately assess fibrosis, although MRI-PDFF is more accurate than CAP in detecting steatosis in overweight and obese patients with NAFLD.https://doi.org/10.1038/s41598-022-25843-6 |
| spellingShingle | Asako Nogami Masato Yoneda Michihiro Iwaki Takashi Kobayashi Takaomi Kessoku Yasushi Honda Yuji Ogawa Kento Imajo Takuma Higurashi Kunihiro Hosono Hiroyuki Kirikoshi Satoru Saito Atsushi Nakajima Diagnostic comparison of vibration-controlled transient elastography and MRI techniques in overweight and obese patients with NAFLD Scientific Reports |
| title | Diagnostic comparison of vibration-controlled transient elastography and MRI techniques in overweight and obese patients with NAFLD |
| title_full | Diagnostic comparison of vibration-controlled transient elastography and MRI techniques in overweight and obese patients with NAFLD |
| title_fullStr | Diagnostic comparison of vibration-controlled transient elastography and MRI techniques in overweight and obese patients with NAFLD |
| title_full_unstemmed | Diagnostic comparison of vibration-controlled transient elastography and MRI techniques in overweight and obese patients with NAFLD |
| title_short | Diagnostic comparison of vibration-controlled transient elastography and MRI techniques in overweight and obese patients with NAFLD |
| title_sort | diagnostic comparison of vibration controlled transient elastography and mri techniques in overweight and obese patients with nafld |
| url | https://doi.org/10.1038/s41598-022-25843-6 |
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