Zinc and pH modulate the ability of insulin to inhibit aggregation of islet amyloid polypeptide
Abstract Aggregation of the human islet amyloid polypeptide (hIAPP) contributes to the development and progression of Type 2 Diabetes (T2D). hIAPP aggregates within a few hours at few micromolar concentration in vitro but exists at millimolar concentrations in vivo. Natively occurring inhibitors of...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-06-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-024-06388-y |