Ubiquitination of α-integrin cytoplasmic tails
Recent findings have shown that ubiquitination is involved in regulating several proteins required for cell adhesion and migration. We showed that α5 integrin is ubiquitinated at its cytoplasmic lysines in response to fibronectin binding, and that this is required for its sorting to lysosomes togeth...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2010-11-01
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| Series: | Communicative & Integrative Biology |
| Online Access: | https://www.tandfonline.com/doi/10.4161/cib.3.6.13176 |
| _version_ | 1827816552614854656 |
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| author | Viola Hélène Lobert Harald Stenmark |
| author_facet | Viola Hélène Lobert Harald Stenmark |
| author_sort | Viola Hélène Lobert |
| collection | DOAJ |
| description | Recent findings have shown that ubiquitination is involved in regulating several proteins required for cell adhesion and migration. We showed that α5 integrin is ubiquitinated at its cytoplasmic lysines in response to fibronectin binding, and that this is required for its sorting to lysosomes together with fibronectin. Here we speculate whether other α integrin tails may also be ubiquitinated, and discuss the significance of ubiquitin linkages in the regulation of cell adhesion and migration. |
| first_indexed | 2024-03-12T00:21:10Z |
| format | Article |
| id | doaj.art-761bdd55d773416db0fdd6276d07d7b2 |
| institution | Directory Open Access Journal |
| issn | 1942-0889 |
| language | English |
| last_indexed | 2024-03-12T00:21:10Z |
| publishDate | 2010-11-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Communicative & Integrative Biology |
| spelling | doaj.art-761bdd55d773416db0fdd6276d07d7b22023-09-15T13:06:45ZengTaylor & Francis GroupCommunicative & Integrative Biology1942-08892010-11-013658358510.4161/cib.3.6.13176Ubiquitination of α-integrin cytoplasmic tailsViola Hélène Lobert0Harald Stenmark1Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Oslo, NorwayCentre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Oslo, NorwayRecent findings have shown that ubiquitination is involved in regulating several proteins required for cell adhesion and migration. We showed that α5 integrin is ubiquitinated at its cytoplasmic lysines in response to fibronectin binding, and that this is required for its sorting to lysosomes together with fibronectin. Here we speculate whether other α integrin tails may also be ubiquitinated, and discuss the significance of ubiquitin linkages in the regulation of cell adhesion and migration.https://www.tandfonline.com/doi/10.4161/cib.3.6.13176 |
| spellingShingle | Viola Hélène Lobert Harald Stenmark Ubiquitination of α-integrin cytoplasmic tails Communicative & Integrative Biology |
| title | Ubiquitination of α-integrin cytoplasmic tails |
| title_full | Ubiquitination of α-integrin cytoplasmic tails |
| title_fullStr | Ubiquitination of α-integrin cytoplasmic tails |
| title_full_unstemmed | Ubiquitination of α-integrin cytoplasmic tails |
| title_short | Ubiquitination of α-integrin cytoplasmic tails |
| title_sort | ubiquitination of α integrin cytoplasmic tails |
| url | https://www.tandfonline.com/doi/10.4161/cib.3.6.13176 |
| work_keys_str_mv | AT violahelenelobert ubiquitinationofaintegrincytoplasmictails AT haraldstenmark ubiquitinationofaintegrincytoplasmictails |