Uterine fibroids and infertility: a controverse but concrete link
Background: Uterine fibroids (UFs) are the most common female benign tumors linked to significant morbidity. There are large literature data connecting UFs with infertility and adverse pregnancy outcome. In this research, authors reviewed literature on UFs, analyzing their relationship with infertil...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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IMR Press
2022-01-01
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| Series: | Clinical and Experimental Obstetrics & Gynecology |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/CEOG/49/1/10.31083/j.ceog4901018 |
| _version_ | 1828747980297994240 |
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| author | Radmila Sparić Mladen Andjić Lazar Nejković Jelena Štulić Aleksandar Dmitrović Radomir Aničić Zagorka Milovanović Đina Tomašević Andrea Tinelli |
| author_facet | Radmila Sparić Mladen Andjić Lazar Nejković Jelena Štulić Aleksandar Dmitrović Radomir Aničić Zagorka Milovanović Đina Tomašević Andrea Tinelli |
| author_sort | Radmila Sparić |
| collection | DOAJ |
| description | Background: Uterine fibroids (UFs) are the most common female benign tumors linked to significant morbidity. There are large literature data connecting UFs with infertility and adverse pregnancy outcome. In this research, authors reviewed literature on UFs, analyzing their relationship with infertility, influence of different therapeutic approaches of UFs on fertility and the possible mechanisms related to UFs and infertility. Methods: MEDLINE and PubMed search, during the years 1990–2020 was performed using a combination of keywords on such topic. Peer-reviewed, systematic review, meta-analysis and prospective trials, examining relationship between UFs and infertility were included in this investigation. According to authors evaluation, additional articles were also identified from the retrieved papers references and included in this narrative review. Results: UFs, especially the submucous and intramural types, with related treatments are linked to impairment of fertility and adverse pregnancy outcome, but many data are conflicting. Molecular mechanisms investigations could explain relationship between UFs and infertility. Conclusion: UFs are linked to infertility and interventions improve fertility. However, many studies conflict in the final results, so further investigations on UFs and infertility should clarify the exact role of molecular mechanisms of this association. |
| first_indexed | 2024-04-14T04:53:01Z |
| format | Article |
| id | doaj.art-761cdd002424483b97302b08db02cffb |
| institution | Directory Open Access Journal |
| issn | 0390-6663 |
| language | English |
| last_indexed | 2024-04-14T04:53:01Z |
| publishDate | 2022-01-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Clinical and Experimental Obstetrics & Gynecology |
| spelling | doaj.art-761cdd002424483b97302b08db02cffb2022-12-22T02:11:14ZengIMR PressClinical and Experimental Obstetrics & Gynecology0390-66632022-01-014911810.31083/j.ceog4901018S0390-6663(22)01667-0Uterine fibroids and infertility: a controverse but concrete linkRadmila Sparić0Mladen Andjić1Lazar Nejković2Jelena Štulić3Aleksandar Dmitrović4Radomir Aničić5Zagorka Milovanović6Đina Tomašević7Andrea Tinelli8Clinic for Gynecology and Obstetrics, University Clinical Centre of Serbia, 11103 Belgrade, SerbiaClinic for Gynecology and Obstetrics, University Clinical Centre of Serbia, 11103 Belgrade, SerbiaSchool of Medicine, University of Belgrade, 11103 Belgrade, SerbiaClinic of Gynecology and Obstetrics, Narodni Front, 11103 Belgrade, SerbiaClinic for Gynecology and Obstetrics, University Clinical Centre of Serbia, 11103 Belgrade, SerbiaSchool of Medicine, University of Belgrade, 11103 Belgrade, SerbiaSchool of Medicine, University of Belgrade, 11103 Belgrade, SerbiaUniversity Clinical Centre of Serbia, 11103 Belgrade, SerbiaDepartment of Obstetrics and Gynecology and CERICSAL (CEntro di RIcerca Clinico SALentino), "Veris delli Ponti Hospital", 73100 Lecce, ItalyBackground: Uterine fibroids (UFs) are the most common female benign tumors linked to significant morbidity. There are large literature data connecting UFs with infertility and adverse pregnancy outcome. In this research, authors reviewed literature on UFs, analyzing their relationship with infertility, influence of different therapeutic approaches of UFs on fertility and the possible mechanisms related to UFs and infertility. Methods: MEDLINE and PubMed search, during the years 1990–2020 was performed using a combination of keywords on such topic. Peer-reviewed, systematic review, meta-analysis and prospective trials, examining relationship between UFs and infertility were included in this investigation. According to authors evaluation, additional articles were also identified from the retrieved papers references and included in this narrative review. Results: UFs, especially the submucous and intramural types, with related treatments are linked to impairment of fertility and adverse pregnancy outcome, but many data are conflicting. Molecular mechanisms investigations could explain relationship between UFs and infertility. Conclusion: UFs are linked to infertility and interventions improve fertility. However, many studies conflict in the final results, so further investigations on UFs and infertility should clarify the exact role of molecular mechanisms of this association.https://www.imrpress.com/journal/CEOG/49/1/10.31083/j.ceog4901018uterine fibroidsleiomyomasfertilitypregnancymyomectomyin vitro fertilizationpregnancy rate |
| spellingShingle | Radmila Sparić Mladen Andjić Lazar Nejković Jelena Štulić Aleksandar Dmitrović Radomir Aničić Zagorka Milovanović Đina Tomašević Andrea Tinelli Uterine fibroids and infertility: a controverse but concrete link Clinical and Experimental Obstetrics & Gynecology uterine fibroids leiomyomas fertility pregnancy myomectomy in vitro fertilization pregnancy rate |
| title | Uterine fibroids and infertility: a controverse but concrete link |
| title_full | Uterine fibroids and infertility: a controverse but concrete link |
| title_fullStr | Uterine fibroids and infertility: a controverse but concrete link |
| title_full_unstemmed | Uterine fibroids and infertility: a controverse but concrete link |
| title_short | Uterine fibroids and infertility: a controverse but concrete link |
| title_sort | uterine fibroids and infertility a controverse but concrete link |
| topic | uterine fibroids leiomyomas fertility pregnancy myomectomy in vitro fertilization pregnancy rate |
| url | https://www.imrpress.com/journal/CEOG/49/1/10.31083/j.ceog4901018 |
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