Pilot results of therapy of adult Ph-negative acute lymphoblastic leukemia according to the protocol of Research Group of Russian Hematological Centers ALL-2009
Aim. To review results of 2-year experience in execution of the protocol on the treatment of adult acute Ph-negative lymphoblastic leukemia ALL-2009. Material and methods. Of 111 patients registered in the study from November 2008 to December 2010 the analysis covered 96 patients from 23 hematologic...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
"Consilium Medicum" Publishing house
2011-07-01
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| Series: | Терапевтический архив |
| Subjects: | |
| Online Access: | https://ter-arkhiv.ru/0040-3660/article/view/30852 |
| _version_ | 1818148693072674816 |
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| author | Elena Nikolaevna Parovichnikova G A Klyasova V G Isaev A N Sokolov A V Kokhno V V Troitskaya E V Mavrina E E Khodunova E N Ustinova E O Gribanova S K Kravchenko V V Ryzhko T S Kaporskaya O Yu Baranova S N Bondarenko A S Nizametdinova E V Kondakova T V Ryl'tsova A N Alufer'eva O S Samoylova O P Skamorina L V Gavrilova A S Pristupa N A Vopilina T S Konstantinova I V Kryuchkova L V Anchukova T S Tikunova K D Kaplanov V A Lapin V A Tumakov M N Kozmina S A Chernysh E I Podol'tseva S M Kulikov Yu R Davidyan V G Savchenko E N Parovichnikova G A Klyasova V G Isaev A N Sokolov A V Kokhno V V Troitskaya E V Mavrina E E Khodunova E N Ustinova E O Gribanova S K Kravchenko V V Ryzhko T S Kaporskaya O Yu Baranova S N Bondarenko A S Nizametdinova E V Kondakova T V Ryltsova A N Aluferieva O S Samoilova O P Skamorina L V Gavrilova A S Pristupa N A Vopilina T S Konstantinova I V Kryuchkova L V Anchukova T S Tikunova K D Kaplanov V A Lapin V A Tumakov M N Kozmina S A Chernysh E I Podoltseva S M Kulikov Yu R Davidyan V G Savchenko |
| author_facet | Elena Nikolaevna Parovichnikova G A Klyasova V G Isaev A N Sokolov A V Kokhno V V Troitskaya E V Mavrina E E Khodunova E N Ustinova E O Gribanova S K Kravchenko V V Ryzhko T S Kaporskaya O Yu Baranova S N Bondarenko A S Nizametdinova E V Kondakova T V Ryl'tsova A N Alufer'eva O S Samoylova O P Skamorina L V Gavrilova A S Pristupa N A Vopilina T S Konstantinova I V Kryuchkova L V Anchukova T S Tikunova K D Kaplanov V A Lapin V A Tumakov M N Kozmina S A Chernysh E I Podol'tseva S M Kulikov Yu R Davidyan V G Savchenko E N Parovichnikova G A Klyasova V G Isaev A N Sokolov A V Kokhno V V Troitskaya E V Mavrina E E Khodunova E N Ustinova E O Gribanova S K Kravchenko V V Ryzhko T S Kaporskaya O Yu Baranova S N Bondarenko A S Nizametdinova E V Kondakova T V Ryltsova A N Aluferieva O S Samoilova O P Skamorina L V Gavrilova A S Pristupa N A Vopilina T S Konstantinova I V Kryuchkova L V Anchukova T S Tikunova K D Kaplanov V A Lapin V A Tumakov M N Kozmina S A Chernysh E I Podoltseva S M Kulikov Yu R Davidyan V G Savchenko |
| author_sort | Elena Nikolaevna Parovichnikova |
| collection | DOAJ |
| description | Aim. To review results of 2-year experience in execution of the protocol on the treatment of adult acute Ph-negative lymphoblastic leukemia ALL-2009.
Material and methods. Of 111 patients registered in the study from November 2008 to December 2010 the analysis covered 96 patients from 23 hematological centers in 18 towns of the RF.
Results. Treatment according to the Protocol ALL-2009 resulted in achievement of a complete remission in 91.2% patients with low early lethality of 5.5%. Postremission lethality fell to 3.7% versus previous studies (22%). Overall 2-year survival and recurrence-free survival reached 77.6 and 78.4%, respectively. Detection of any chromosomic aberrations significantly affected recurrence-free survival: 74 vs 100% in patients with normal karyotype.
Conclusion. Protocol All-2009 demonstrates high efficacy in moderate toxicity and good reproducibility in any hematologic center. |
| first_indexed | 2024-12-11T12:55:11Z |
| format | Article |
| id | doaj.art-761e0f1d85ab4a908e1991369cfd8ab5 |
| institution | Directory Open Access Journal |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| last_indexed | 2024-12-11T12:55:11Z |
| publishDate | 2011-07-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj.art-761e0f1d85ab4a908e1991369cfd8ab52022-12-22T01:06:36Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422011-07-01837111727871Pilot results of therapy of adult Ph-negative acute lymphoblastic leukemia according to the protocol of Research Group of Russian Hematological Centers ALL-2009Elena Nikolaevna ParovichnikovaG A KlyasovaV G IsaevA N SokolovA V KokhnoV V TroitskayaE V MavrinaE E KhodunovaE N UstinovaE O GribanovaS K KravchenkoV V RyzhkoT S KaporskayaO Yu BaranovaS N BondarenkoA S NizametdinovaE V KondakovaT V Ryl'tsovaA N Alufer'evaO S SamoylovaO P SkamorinaL V GavrilovaA S PristupaN A VopilinaT S KonstantinovaI V KryuchkovaL V AnchukovaT S TikunovaK D KaplanovV A LapinV A TumakovM N KozminaS A ChernyshE I Podol'tsevaS M KulikovYu R DavidyanV G SavchenkoE N Parovichnikova0G A Klyasova1V G Isaev2A N Sokolov3A V Kokhno4V V Troitskaya5E V Mavrina6E E Khodunova7E N Ustinova8E O Gribanova9S K Kravchenko10V V Ryzhko11T S Kaporskaya12O Yu Baranova13S N Bondarenko14A S Nizametdinova15E V Kondakova16T V Ryltsova17A N Aluferieva18O S Samoilova19O P Skamorina20L V Gavrilova21A S Pristupa22N A Vopilina23T S Konstantinova24I V Kryuchkova25L V Anchukova26T S Tikunova27K D Kaplanov28V A Lapin29V A Tumakov30M N Kozmina31S A Chernysh32E I Podoltseva33S M Kulikov34Yu R Davidyan35V G Savchenko36Hematological Research Center, MoscowHematological Research Center, MoscowHematological Research Center, MoscowHematological Research Center, MoscowHematological Research Center, MoscowHematological Research Center, MoscowHematological Research Center, MoscowHematological Research Center, MoscowHematological Research Center, MoscowHematological Research Center, MoscowHematological Research Center, MoscowHematological Research Center, MoscowRegional hospital, IrkutskN.N. Blokhin Russian Cancer Research CenterState Medical University, St-PetersburgCity hospital N 17, St-PetersburgRegional hospital, SurgutRegional hospital, TulaRegional hospital, SamaraRegional hospital, N. NovgorodCentral hospital of GSS, MoscowRegional hospital, SaranskRegional hospital, RyazanRegional hospital, TambovRegional hospital, EkaterinburgResearch Clinical Institute, NovosibirskRegional hospital, VologdaRegional hospital, BelgorodRegional hospital, VolgogradRegional hospital, YaroslavlRegional hospital, IvanovoRegional hospital, OrelS.P. Botkin City hospital, MoscowCity hospital N 23, St-PetersburgHematological Research Center, MoscowHematological Research Center, MoscowHematological Research Center, MoscowAim. To review results of 2-year experience in execution of the protocol on the treatment of adult acute Ph-negative lymphoblastic leukemia ALL-2009. Material and methods. Of 111 patients registered in the study from November 2008 to December 2010 the analysis covered 96 patients from 23 hematological centers in 18 towns of the RF. Results. Treatment according to the Protocol ALL-2009 resulted in achievement of a complete remission in 91.2% patients with low early lethality of 5.5%. Postremission lethality fell to 3.7% versus previous studies (22%). Overall 2-year survival and recurrence-free survival reached 77.6 and 78.4%, respectively. Detection of any chromosomic aberrations significantly affected recurrence-free survival: 74 vs 100% in patients with normal karyotype. Conclusion. Protocol All-2009 demonstrates high efficacy in moderate toxicity and good reproducibility in any hematologic center.https://ter-arkhiv.ru/0040-3660/article/view/30852adult ph-negative acute lymphoblastic leukemiasensitivity to prednisolonel-asparaginasa |
| spellingShingle | Elena Nikolaevna Parovichnikova G A Klyasova V G Isaev A N Sokolov A V Kokhno V V Troitskaya E V Mavrina E E Khodunova E N Ustinova E O Gribanova S K Kravchenko V V Ryzhko T S Kaporskaya O Yu Baranova S N Bondarenko A S Nizametdinova E V Kondakova T V Ryl'tsova A N Alufer'eva O S Samoylova O P Skamorina L V Gavrilova A S Pristupa N A Vopilina T S Konstantinova I V Kryuchkova L V Anchukova T S Tikunova K D Kaplanov V A Lapin V A Tumakov M N Kozmina S A Chernysh E I Podol'tseva S M Kulikov Yu R Davidyan V G Savchenko E N Parovichnikova G A Klyasova V G Isaev A N Sokolov A V Kokhno V V Troitskaya E V Mavrina E E Khodunova E N Ustinova E O Gribanova S K Kravchenko V V Ryzhko T S Kaporskaya O Yu Baranova S N Bondarenko A S Nizametdinova E V Kondakova T V Ryltsova A N Aluferieva O S Samoilova O P Skamorina L V Gavrilova A S Pristupa N A Vopilina T S Konstantinova I V Kryuchkova L V Anchukova T S Tikunova K D Kaplanov V A Lapin V A Tumakov M N Kozmina S A Chernysh E I Podoltseva S M Kulikov Yu R Davidyan V G Savchenko Pilot results of therapy of adult Ph-negative acute lymphoblastic leukemia according to the protocol of Research Group of Russian Hematological Centers ALL-2009 Терапевтический архив adult ph-negative acute lymphoblastic leukemia sensitivity to prednisolone l-asparaginasa |
| title | Pilot results of therapy of adult Ph-negative acute lymphoblastic leukemia according to the protocol of Research Group of Russian Hematological Centers ALL-2009 |
| title_full | Pilot results of therapy of adult Ph-negative acute lymphoblastic leukemia according to the protocol of Research Group of Russian Hematological Centers ALL-2009 |
| title_fullStr | Pilot results of therapy of adult Ph-negative acute lymphoblastic leukemia according to the protocol of Research Group of Russian Hematological Centers ALL-2009 |
| title_full_unstemmed | Pilot results of therapy of adult Ph-negative acute lymphoblastic leukemia according to the protocol of Research Group of Russian Hematological Centers ALL-2009 |
| title_short | Pilot results of therapy of adult Ph-negative acute lymphoblastic leukemia according to the protocol of Research Group of Russian Hematological Centers ALL-2009 |
| title_sort | pilot results of therapy of adult ph negative acute lymphoblastic leukemia according to the protocol of research group of russian hematological centers all 2009 |
| topic | adult ph-negative acute lymphoblastic leukemia sensitivity to prednisolone l-asparaginasa |
| url | https://ter-arkhiv.ru/0040-3660/article/view/30852 |
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