Analysis of Efficacy of DICE (Dexamethasone, Ifosfamide, Cisplatin and Etoposide) Regimen on Recurrent and Refractory Intermediate and High Grade Non-Hodgkin's Lymphoma
OBJECTIVE Thus far there is no standard salvage regimen for patients with recurrent and refractory intermediate and high grade non-Hodgkin’s lymphoma (NHL). This study intends to investigate the therapeutic efficacy of the DICE (dexamethasone, isofosfamide, cisplatin and etoposide) regimen on the...
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| Format: | Article |
| Language: | English |
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China Anti-Cancer Association
2009-02-01
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| Series: | Cancer Biology & Medicine |
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| Online Access: | http://www.cancerbiomed.org/index.php/cocr/article/view/176 |
| _version_ | 1817996655821062144 |
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| author | Lei YANG Zhucheng SONG Xiaohong XU |
| author_facet | Lei YANG Zhucheng SONG Xiaohong XU |
| author_sort | Lei YANG |
| collection | DOAJ |
| description | OBJECTIVE Thus far there is no standard salvage regimen for patients with recurrent and refractory intermediate and high grade non-Hodgkin’s lymphoma (NHL). This study intends to investigate the therapeutic efficacy of the DICE (dexamethasone, isofosfamide, cisplatin and etoposide) regimen on the recurrent and refractory NHL, and to observe the related adverse effects. METHODS Clinical records of 22 patients with recurrent and refractory NHL, who failed to achieve a remission from the CHOP [cyclophosphamide, hydroxydaunomycin/doxorubicin (adriamycin), oncovin, prednisone] regimen within 2 to 6 cycles of treatment, were reviewed. DICE, as a salvage regimen with a median course of treatment of 4 cycles (ranging from 2 to 7 cycles), was now used, and evaluation of the therapeutic efficacy and adverse eff ect of DICE was conducted in all the patients. Of the 22 NHL cases, 8 were of T-cell origin and the other 14 B-cell origin. Salvage treatment was performed in the patients, with appraisal, prevention and treatment of the toxic reactions. RESULTS Following DICE treatment in the 22 patients, the total effective rate of the regimen was 63.6%, and the complete remission (CR) rate was 40.9%. The effective rates of DICE on the T and B-cell sourced NHL were 75.0% and 57.1%, and the CR rate were 37.5%, 42.9%, respectively ( P > 0.05). An increase of the lactate dehydrogenase (LDH) level accompanied by a giant lump was the short-term effect on patients with recurrence (mean P < 0.05) who were drug resistant. Myelosuppression, digestive system reaction and alopecia were the commonly-seen complications in the patients who received DICE regimen. All patients recovered after treatment, and no chemotherapy-related death occurred. CONCLUSION DICE regimen is effective in treating refractory and recurrent NHL. |
| first_indexed | 2024-04-14T02:26:32Z |
| format | Article |
| id | doaj.art-761fe6324a4641b9b3e4478904a2bcb8 |
| institution | Directory Open Access Journal |
| issn | 2095-3941 |
| language | English |
| last_indexed | 2024-04-14T02:26:32Z |
| publishDate | 2009-02-01 |
| publisher | China Anti-Cancer Association |
| record_format | Article |
| series | Cancer Biology & Medicine |
| spelling | doaj.art-761fe6324a4641b9b3e4478904a2bcb82022-12-22T02:17:52ZengChina Anti-Cancer AssociationCancer Biology & Medicine2095-39412009-02-0161596310.1007/s11805-009-0059-1Analysis of Efficacy of DICE (Dexamethasone, Ifosfamide, Cisplatin and Etoposide) Regimen on Recurrent and Refractory Intermediate and High Grade Non-Hodgkin's LymphomaLei YANGZhucheng SONGXiaohong XUOBJECTIVE Thus far there is no standard salvage regimen for patients with recurrent and refractory intermediate and high grade non-Hodgkin’s lymphoma (NHL). This study intends to investigate the therapeutic efficacy of the DICE (dexamethasone, isofosfamide, cisplatin and etoposide) regimen on the recurrent and refractory NHL, and to observe the related adverse effects. METHODS Clinical records of 22 patients with recurrent and refractory NHL, who failed to achieve a remission from the CHOP [cyclophosphamide, hydroxydaunomycin/doxorubicin (adriamycin), oncovin, prednisone] regimen within 2 to 6 cycles of treatment, were reviewed. DICE, as a salvage regimen with a median course of treatment of 4 cycles (ranging from 2 to 7 cycles), was now used, and evaluation of the therapeutic efficacy and adverse eff ect of DICE was conducted in all the patients. Of the 22 NHL cases, 8 were of T-cell origin and the other 14 B-cell origin. Salvage treatment was performed in the patients, with appraisal, prevention and treatment of the toxic reactions. RESULTS Following DICE treatment in the 22 patients, the total effective rate of the regimen was 63.6%, and the complete remission (CR) rate was 40.9%. The effective rates of DICE on the T and B-cell sourced NHL were 75.0% and 57.1%, and the CR rate were 37.5%, 42.9%, respectively ( P > 0.05). An increase of the lactate dehydrogenase (LDH) level accompanied by a giant lump was the short-term effect on patients with recurrence (mean P < 0.05) who were drug resistant. Myelosuppression, digestive system reaction and alopecia were the commonly-seen complications in the patients who received DICE regimen. All patients recovered after treatment, and no chemotherapy-related death occurred. CONCLUSION DICE regimen is effective in treating refractory and recurrent NHL.http://www.cancerbiomed.org/index.php/cocr/article/view/176Non-Hodgkin’s lymphomachemotherapyDICE regimentherapeutic effectadverse effect. |
| spellingShingle | Lei YANG Zhucheng SONG Xiaohong XU Analysis of Efficacy of DICE (Dexamethasone, Ifosfamide, Cisplatin and Etoposide) Regimen on Recurrent and Refractory Intermediate and High Grade Non-Hodgkin's Lymphoma Cancer Biology & Medicine Non-Hodgkin’s lymphoma chemotherapy DICE regimen therapeutic effect adverse effect. |
| title | Analysis of Efficacy of DICE (Dexamethasone, Ifosfamide, Cisplatin and Etoposide) Regimen on Recurrent and Refractory Intermediate and High Grade Non-Hodgkin's Lymphoma |
| title_full | Analysis of Efficacy of DICE (Dexamethasone, Ifosfamide, Cisplatin and Etoposide) Regimen on Recurrent and Refractory Intermediate and High Grade Non-Hodgkin's Lymphoma |
| title_fullStr | Analysis of Efficacy of DICE (Dexamethasone, Ifosfamide, Cisplatin and Etoposide) Regimen on Recurrent and Refractory Intermediate and High Grade Non-Hodgkin's Lymphoma |
| title_full_unstemmed | Analysis of Efficacy of DICE (Dexamethasone, Ifosfamide, Cisplatin and Etoposide) Regimen on Recurrent and Refractory Intermediate and High Grade Non-Hodgkin's Lymphoma |
| title_short | Analysis of Efficacy of DICE (Dexamethasone, Ifosfamide, Cisplatin and Etoposide) Regimen on Recurrent and Refractory Intermediate and High Grade Non-Hodgkin's Lymphoma |
| title_sort | analysis of efficacy of dice dexamethasone ifosfamide cisplatin and etoposide regimen on recurrent and refractory intermediate and high grade non hodgkin s lymphoma |
| topic | Non-Hodgkin’s lymphoma chemotherapy DICE regimen therapeutic effect adverse effect. |
| url | http://www.cancerbiomed.org/index.php/cocr/article/view/176 |
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