Genomic Characterization of the Genus Nairovirus (Family Bunyaviridae)
Nairovirus, one of five bunyaviral genera, includes seven species. Genomic sequence information is limited for members of the Dera Ghazi Khan, Hughes, Qalyub, Sakhalin, and Thiafora nairovirus species. We used next-generation sequencing and historical virus-culture samples to determine 14 complete a...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2016-06-01
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| Series: | Viruses |
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| Online Access: | http://www.mdpi.com/1999-4915/8/6/164 |
| _version_ | 1819264808247099392 |
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| author | Jens H. Kuhn Michael R. Wiley Sergio E. Rodriguez Yīmíng Bào Karla Prieto Amelia P. A. Travassos da Rosa Hilda Guzman Nazir Savji Jason T. Ladner Robert B. Tesh Jiro Wada Peter B. Jahrling Dennis A. Bente Gustavo Palacios |
| author_facet | Jens H. Kuhn Michael R. Wiley Sergio E. Rodriguez Yīmíng Bào Karla Prieto Amelia P. A. Travassos da Rosa Hilda Guzman Nazir Savji Jason T. Ladner Robert B. Tesh Jiro Wada Peter B. Jahrling Dennis A. Bente Gustavo Palacios |
| author_sort | Jens H. Kuhn |
| collection | DOAJ |
| description | Nairovirus, one of five bunyaviral genera, includes seven species. Genomic sequence information is limited for members of the Dera Ghazi Khan, Hughes, Qalyub, Sakhalin, and Thiafora nairovirus species. We used next-generation sequencing and historical virus-culture samples to determine 14 complete and nine coding-complete nairoviral genome sequences to further characterize these species. Previously unsequenced viruses include Abu Mina, Clo Mor, Great Saltee, Hughes, Raza, Sakhalin, Soldado, and Tillamook viruses. In addition, we present genomic sequence information on additional isolates of previously sequenced Avalon, Dugbe, Sapphire II, and Zirqa viruses. Finally, we identify Tunis virus, previously thought to be a phlebovirus, as an isolate of Abu Hammad virus. Phylogenetic analyses indicate the need for reassignment of Sapphire II virus to Dera Ghazi Khan nairovirus and reassignment of Hazara, Tofla, and Nairobi sheep disease viruses to novel species. We also propose new species for the Kasokero group (Kasokero, Leopards Hill, Yogue viruses), the Ketarah group (Gossas, Issyk-kul, Keterah/soft tick viruses) and the Burana group (Wēnzhōu tick virus, Huángpí tick virus 1, Tǎchéng tick virus 1). Our analyses emphasize the sister relationship of nairoviruses and arenaviruses, and indicate that several nairo-like viruses (Shāyáng spider virus 1, Xīnzhōu spider virus, Sānxiá water strider virus 1, South Bay virus, Wǔhàn millipede virus 2) require establishment of novel genera in a larger nairovirus-arenavirus supergroup. |
| first_indexed | 2024-12-23T20:35:22Z |
| format | Article |
| id | doaj.art-7620e956959d4f36b50c5177e4fda114 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-12-23T20:35:22Z |
| publishDate | 2016-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-7620e956959d4f36b50c5177e4fda1142022-12-21T17:32:07ZengMDPI AGViruses1999-49152016-06-018616410.3390/v8060164v8060164Genomic Characterization of the Genus Nairovirus (Family Bunyaviridae)Jens H. Kuhn0Michael R. Wiley1Sergio E. Rodriguez2Yīmíng Bào3Karla Prieto4Amelia P. A. Travassos da Rosa5Hilda Guzman6Nazir Savji7Jason T. Ladner8Robert B. Tesh9Jiro Wada10Peter B. Jahrling11Dennis A. Bente12Gustavo Palacios13Integrated Research Facility at Fort Detrick, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USACenter for Genome Sciences, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USAGalveston National Laboratory, Institute for Human Infection and Immunity, Department of Microbiology & Immunology, University of Texas Medical Branch, Galveston, TX 77555, USAInformation Engineering Branch, National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20892, USACenter for Genome Sciences, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USAGalveston National Laboratory, Institute for Human Infection and Immunity, Department of Microbiology & Immunology, University of Texas Medical Branch, Galveston, TX 77555, USAGalveston National Laboratory, Institute for Human Infection and Immunity, Department of Microbiology & Immunology, University of Texas Medical Branch, Galveston, TX 77555, USASchool of Medicine, New York University, New York, NY 10016, USACenter for Genome Sciences, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USAGalveston National Laboratory, Institute for Human Infection and Immunity, Department of Microbiology & Immunology, University of Texas Medical Branch, Galveston, TX 77555, USAIntegrated Research Facility at Fort Detrick, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USAIntegrated Research Facility at Fort Detrick, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USAGalveston National Laboratory, Institute for Human Infection and Immunity, Department of Microbiology & Immunology, University of Texas Medical Branch, Galveston, TX 77555, USACenter for Genome Sciences, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USANairovirus, one of five bunyaviral genera, includes seven species. Genomic sequence information is limited for members of the Dera Ghazi Khan, Hughes, Qalyub, Sakhalin, and Thiafora nairovirus species. We used next-generation sequencing and historical virus-culture samples to determine 14 complete and nine coding-complete nairoviral genome sequences to further characterize these species. Previously unsequenced viruses include Abu Mina, Clo Mor, Great Saltee, Hughes, Raza, Sakhalin, Soldado, and Tillamook viruses. In addition, we present genomic sequence information on additional isolates of previously sequenced Avalon, Dugbe, Sapphire II, and Zirqa viruses. Finally, we identify Tunis virus, previously thought to be a phlebovirus, as an isolate of Abu Hammad virus. Phylogenetic analyses indicate the need for reassignment of Sapphire II virus to Dera Ghazi Khan nairovirus and reassignment of Hazara, Tofla, and Nairobi sheep disease viruses to novel species. We also propose new species for the Kasokero group (Kasokero, Leopards Hill, Yogue viruses), the Ketarah group (Gossas, Issyk-kul, Keterah/soft tick viruses) and the Burana group (Wēnzhōu tick virus, Huángpí tick virus 1, Tǎchéng tick virus 1). Our analyses emphasize the sister relationship of nairoviruses and arenaviruses, and indicate that several nairo-like viruses (Shāyáng spider virus 1, Xīnzhōu spider virus, Sānxiá water strider virus 1, South Bay virus, Wǔhàn millipede virus 2) require establishment of novel genera in a larger nairovirus-arenavirus supergroup.http://www.mdpi.com/1999-4915/8/6/164BunyaviridaebunyavirusnairovirusDera Ghazi Khan virusErve virusGanjam virusHughes virusQalyub virusSakhalin virusTunis virusvirus classificationvirus taxonomy |
| spellingShingle | Jens H. Kuhn Michael R. Wiley Sergio E. Rodriguez Yīmíng Bào Karla Prieto Amelia P. A. Travassos da Rosa Hilda Guzman Nazir Savji Jason T. Ladner Robert B. Tesh Jiro Wada Peter B. Jahrling Dennis A. Bente Gustavo Palacios Genomic Characterization of the Genus Nairovirus (Family Bunyaviridae) Viruses Bunyaviridae bunyavirus nairovirus Dera Ghazi Khan virus Erve virus Ganjam virus Hughes virus Qalyub virus Sakhalin virus Tunis virus virus classification virus taxonomy |
| title | Genomic Characterization of the Genus Nairovirus (Family Bunyaviridae) |
| title_full | Genomic Characterization of the Genus Nairovirus (Family Bunyaviridae) |
| title_fullStr | Genomic Characterization of the Genus Nairovirus (Family Bunyaviridae) |
| title_full_unstemmed | Genomic Characterization of the Genus Nairovirus (Family Bunyaviridae) |
| title_short | Genomic Characterization of the Genus Nairovirus (Family Bunyaviridae) |
| title_sort | genomic characterization of the genus nairovirus family bunyaviridae |
| topic | Bunyaviridae bunyavirus nairovirus Dera Ghazi Khan virus Erve virus Ganjam virus Hughes virus Qalyub virus Sakhalin virus Tunis virus virus classification virus taxonomy |
| url | http://www.mdpi.com/1999-4915/8/6/164 |
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