Zoledronic acid induces ferroptosis by reducing ubiquinone and promoting HMOX1 expression in osteosarcoma cells

Zoledronic acid induces ferroptosis by reducing ubiquinone and promoting HMOX1 expression in osteosarcoma cells

Aims: Ferroptosis plays important roles in tumorigenesis and cancer therapy. Zoledronic acid is known to inhibit the activity of farnesyl pyrophosphate synthase, a key enzyme in the mevalonate pathway. We examined whether zoledronic acid can inhibit the growth of osteosarcoma cells by inducing ferro...

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Bibliographic Details
Main Authors: Tianhao Ren, Ju Huang, Wei Sun, Guangze Wang, Yuwen Wu, Zewei Jiang, Yingshuai Lv, Guang Wu, Jiawei Cao, Min Liu, Haihua Gu
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Pharmacology
Subjects:
zoledronic acid
ferroptosis
ubiquinone
HMOX1
osteosarcoma
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.1071946/full

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