Adenovirus and Oxaliplatin cooperate as agnostic sensitizers for immunogenic cell death in colorectal carcinoma

Adenovirus and Oxaliplatin cooperate as agnostic sensitizers for immunogenic cell death in colorectal carcinoma

Treatments with cytotoxic agents or viruses may cause Immunogenic Cell Death (ICD) that immunize tumor-bearing hosts but do not cause complete regression of tumor. We postulate that combining two ICD inducers may cause durable regression in immunocompetent mice. ICD was optimized in vitro by maximiz...

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Bibliographic Details
Main Authors: J. Milburn Jessup, Mohamed Kabbout, Nikolay Korokhov, Alex Joun, Ann E. Tollefson, William S. M. Wold, Abid R. Mattoo
Format: Article
Language:English
Published: Taylor & Francis Group 2020-03-01
Series:Human Vaccines & Immunotherapeutics
Subjects:
adenovirus
immunogenic cell death
complete response
rectal carcinoma
calreticulin
ct26
4t1
oxaliplatin
Online Access:http://dx.doi.org/10.1080/21645515.2019.1665960

Internet

http://dx.doi.org/10.1080/21645515.2019.1665960

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