Rescue of mitochondrial import failure by intercellular organellar transfer
Abstract Mitochondria are the powerhouses of eukaryotic cells, composed mostly of nuclear-encoded proteins imported from the cytosol. Thus, problems with the import machinery will disrupt their regenerative capacity and the cell’s energy supplies – particularly troublesome for energy-demanding cells...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-45283-2 |
| _version_ | 1797274099961036800 |
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| author | Hope I. Needs Emily Glover Gonçalo C. Pereira Alina Witt Wolfgang Hübner Mark P. Dodding Jeremy M. Henley Ian Collinson |
| author_facet | Hope I. Needs Emily Glover Gonçalo C. Pereira Alina Witt Wolfgang Hübner Mark P. Dodding Jeremy M. Henley Ian Collinson |
| author_sort | Hope I. Needs |
| collection | DOAJ |
| description | Abstract Mitochondria are the powerhouses of eukaryotic cells, composed mostly of nuclear-encoded proteins imported from the cytosol. Thus, problems with the import machinery will disrupt their regenerative capacity and the cell’s energy supplies – particularly troublesome for energy-demanding cells of nervous tissue and muscle. Unsurprisingly then, import breakdown is implicated in disease. Here, we explore the consequences of import failure in mammalian cells; wherein, blocking the import machinery impacts mitochondrial ultra-structure and dynamics, but, surprisingly, does not affect import. Our data are consistent with a response involving intercellular mitochondrial transport via tunnelling nanotubes to import healthy mitochondria and jettison those with blocked import sites. These observations support the existence of a widespread mechanism for the rescue of mitochondrial dysfunction. |
| first_indexed | 2024-03-07T14:53:33Z |
| format | Article |
| id | doaj.art-76241f22b7d343e9b3d616b1e3d7924b |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-03-07T14:53:33Z |
| publishDate | 2024-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-76241f22b7d343e9b3d616b1e3d7924b2024-03-05T19:32:42ZengNature PortfolioNature Communications2041-17232024-02-0115111710.1038/s41467-024-45283-2Rescue of mitochondrial import failure by intercellular organellar transferHope I. Needs0Emily Glover1Gonçalo C. Pereira2Alina Witt3Wolfgang Hübner4Mark P. Dodding5Jeremy M. Henley6Ian Collinson7School of Biochemistry, University of BristolSchool of Biochemistry, University of BristolSchool of Biochemistry, University of BristolFakultät für Physik, Universität BielefeldFakultät für Physik, Universität BielefeldSchool of Biochemistry, University of BristolSchool of Biochemistry, University of BristolSchool of Biochemistry, University of BristolAbstract Mitochondria are the powerhouses of eukaryotic cells, composed mostly of nuclear-encoded proteins imported from the cytosol. Thus, problems with the import machinery will disrupt their regenerative capacity and the cell’s energy supplies – particularly troublesome for energy-demanding cells of nervous tissue and muscle. Unsurprisingly then, import breakdown is implicated in disease. Here, we explore the consequences of import failure in mammalian cells; wherein, blocking the import machinery impacts mitochondrial ultra-structure and dynamics, but, surprisingly, does not affect import. Our data are consistent with a response involving intercellular mitochondrial transport via tunnelling nanotubes to import healthy mitochondria and jettison those with blocked import sites. These observations support the existence of a widespread mechanism for the rescue of mitochondrial dysfunction.https://doi.org/10.1038/s41467-024-45283-2 |
| spellingShingle | Hope I. Needs Emily Glover Gonçalo C. Pereira Alina Witt Wolfgang Hübner Mark P. Dodding Jeremy M. Henley Ian Collinson Rescue of mitochondrial import failure by intercellular organellar transfer Nature Communications |
| title | Rescue of mitochondrial import failure by intercellular organellar transfer |
| title_full | Rescue of mitochondrial import failure by intercellular organellar transfer |
| title_fullStr | Rescue of mitochondrial import failure by intercellular organellar transfer |
| title_full_unstemmed | Rescue of mitochondrial import failure by intercellular organellar transfer |
| title_short | Rescue of mitochondrial import failure by intercellular organellar transfer |
| title_sort | rescue of mitochondrial import failure by intercellular organellar transfer |
| url | https://doi.org/10.1038/s41467-024-45283-2 |
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