The Role of Lyophilized Xenodermotransplants in Repairing the Atria’s Structure and the Peculiarities of Regenerative Processes after Thermal Trauma in an Experiment
The effects of severe burn injuries on the cardiovascular system, specifically the atria and auricles of the heart, were investigated. The potential benefits of using lyophilized xenodermotransplants as a treatment option were also evaluated. The experiments were conducted on adult guinea pigs divid...
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MDPI AG
2023-06-01
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| Online Access: | https://www.mdpi.com/2075-1729/13/7/1470 |
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| author | Adam Osowski Iryna Hetmaniuk Olena Fedchyshyn Mykhailo Sas Yuliia Lomakina Nataliia Tkachuk Olena Budarna Volodymyr Fik Larisa Fedoniuk Joanna Wojtkiewicz |
| author_facet | Adam Osowski Iryna Hetmaniuk Olena Fedchyshyn Mykhailo Sas Yuliia Lomakina Nataliia Tkachuk Olena Budarna Volodymyr Fik Larisa Fedoniuk Joanna Wojtkiewicz |
| author_sort | Adam Osowski |
| collection | DOAJ |
| description | The effects of severe burn injuries on the cardiovascular system, specifically the atria and auricles of the heart, were investigated. The potential benefits of using lyophilized xenodermotransplants as a treatment option were also evaluated. The experiments were conducted on adult guinea pigs divided into three groups: intact animals, animals with burns, and animals with burns who underwent early necrectomy followed by wound closure with lyophilized xenodermotransplants. Third-degree burns caused significant ultrastructural changes in atrial cardiomyocytes, leading to long-term destructive changes in the structural components of the atria. However, the use of lyophilized xenodermotransplants had a positive effect on the atrial ultrastructure over time. This study highlights the complex and varied effects of burn injuries on the body and the potential benefits of lyophilized xenodermotransplants in treating severe burn injuries. By preventing destructive changes in the heart and activating regenerative processes, lyophilized xenodermotransplants can improve the condition of the heart after thermal injury. Further research and development in this area are necessary for understanding the potential of lyophilized xenodermotransplants in tissue repair and regeneration. |
| first_indexed | 2024-03-11T00:54:47Z |
| format | Article |
| id | doaj.art-76243c4ea60c4bb9b95870c4744b9254 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-11T00:54:47Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-76243c4ea60c4bb9b95870c4744b92542023-11-18T20:08:54ZengMDPI AGLife2075-17292023-06-01137147010.3390/life13071470The Role of Lyophilized Xenodermotransplants in Repairing the Atria’s Structure and the Peculiarities of Regenerative Processes after Thermal Trauma in an ExperimentAdam Osowski0Iryna Hetmaniuk1Olena Fedchyshyn2Mykhailo Sas3Yuliia Lomakina4Nataliia Tkachuk5Olena Budarna6Volodymyr Fik7Larisa Fedoniuk8Joanna Wojtkiewicz9Department of Human Physiology and Pathophysiology, University of Warmia and Mazury in Olsztyn, 2 Oczapowskiego Street, 10-719 Olsztyn, PolandMedical Biology Department, Horbachevsky Ternopil National Medical University, 2 Yu. Slovatskyi Street, 46001 Ternopil, UkraineMedical Biology Department, Horbachevsky Ternopil National Medical University, 2 Yu. Slovatskyi Street, 46001 Ternopil, UkraineMedical Biology Department, Horbachevsky Ternopil National Medical University, 2 Yu. Slovatskyi Street, 46001 Ternopil, UkraineDepartment of Medical Biology and Genetics, Bukovinian State Medical University, 15 Yu. Fedkovich Street, 58000 Chernivtsi, UkraineMedical Biology Department, Horbachevsky Ternopil National Medical University, 2 Yu. Slovatskyi Street, 46001 Ternopil, UkraineMedical Biology Department, Horbachevsky Ternopil National Medical University, 2 Yu. Slovatskyi Street, 46001 Ternopil, UkraineDepartment of Normal Anatomy, Danylo Halytsky Lviv National Medical University, 69 Pekarska Street, 79010 Lviv, UkraineMedical Biology Department, Horbachevsky Ternopil National Medical University, 2 Yu. Slovatskyi Street, 46001 Ternopil, UkraineDepartment of Human Physiology and Pathophysiology, University of Warmia and Mazury in Olsztyn, 2 Oczapowskiego Street, 10-719 Olsztyn, PolandThe effects of severe burn injuries on the cardiovascular system, specifically the atria and auricles of the heart, were investigated. The potential benefits of using lyophilized xenodermotransplants as a treatment option were also evaluated. The experiments were conducted on adult guinea pigs divided into three groups: intact animals, animals with burns, and animals with burns who underwent early necrectomy followed by wound closure with lyophilized xenodermotransplants. Third-degree burns caused significant ultrastructural changes in atrial cardiomyocytes, leading to long-term destructive changes in the structural components of the atria. However, the use of lyophilized xenodermotransplants had a positive effect on the atrial ultrastructure over time. This study highlights the complex and varied effects of burn injuries on the body and the potential benefits of lyophilized xenodermotransplants in treating severe burn injuries. By preventing destructive changes in the heart and activating regenerative processes, lyophilized xenodermotransplants can improve the condition of the heart after thermal injury. Further research and development in this area are necessary for understanding the potential of lyophilized xenodermotransplants in tissue repair and regeneration.https://www.mdpi.com/2075-1729/13/7/1470atria and auricles of the heartmorphological changesmicroscopymicroscopythermal traumabiological lyophilized xenografts |
| spellingShingle | Adam Osowski Iryna Hetmaniuk Olena Fedchyshyn Mykhailo Sas Yuliia Lomakina Nataliia Tkachuk Olena Budarna Volodymyr Fik Larisa Fedoniuk Joanna Wojtkiewicz The Role of Lyophilized Xenodermotransplants in Repairing the Atria’s Structure and the Peculiarities of Regenerative Processes after Thermal Trauma in an Experiment Life atria and auricles of the heart morphological changes microscopy microscopy thermal trauma biological lyophilized xenografts |
| title | The Role of Lyophilized Xenodermotransplants in Repairing the Atria’s Structure and the Peculiarities of Regenerative Processes after Thermal Trauma in an Experiment |
| title_full | The Role of Lyophilized Xenodermotransplants in Repairing the Atria’s Structure and the Peculiarities of Regenerative Processes after Thermal Trauma in an Experiment |
| title_fullStr | The Role of Lyophilized Xenodermotransplants in Repairing the Atria’s Structure and the Peculiarities of Regenerative Processes after Thermal Trauma in an Experiment |
| title_full_unstemmed | The Role of Lyophilized Xenodermotransplants in Repairing the Atria’s Structure and the Peculiarities of Regenerative Processes after Thermal Trauma in an Experiment |
| title_short | The Role of Lyophilized Xenodermotransplants in Repairing the Atria’s Structure and the Peculiarities of Regenerative Processes after Thermal Trauma in an Experiment |
| title_sort | role of lyophilized xenodermotransplants in repairing the atria s structure and the peculiarities of regenerative processes after thermal trauma in an experiment |
| topic | atria and auricles of the heart morphological changes microscopy microscopy thermal trauma biological lyophilized xenografts |
| url | https://www.mdpi.com/2075-1729/13/7/1470 |
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