Evaluation of levothyroxine effect on pulmonary function inhypothyroidism
(Received 14 Jul, 2008; Accepted 12 Nov, 2008) Abstract Background and purpose: Hypothyroidism is one of the most common diseases in endocrinology Thyroid hormone deficiency effects on nerve and muscle fibers, pulmonary system and alveolar ventilation. The aim of this study was to evaluate the effec...
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| Format: | Article |
| Language: | English |
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Mazandaran University of Medical Sciences
2008-01-01
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| Series: | Journal of Mazandaran University of Medical Sciences |
| Subjects: | |
| Online Access: | http://www.mazums.ac.ir/index.php?digital_library&do=absview&lang=persian&sid=682 |
| _version_ | 1811311169441366016 |
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| author | Hamid Reza Zakeri Zhila Torabi Zadeh Ali Sharif Poor Zahra Kashi Ozra Akha |
| author_facet | Hamid Reza Zakeri Zhila Torabi Zadeh Ali Sharif Poor Zahra Kashi Ozra Akha |
| author_sort | Hamid Reza Zakeri |
| collection | DOAJ |
| description | (Received 14 Jul, 2008; Accepted 12 Nov, 2008) Abstract Background and purpose: Hypothyroidism is one of the most common diseases in endocrinology Thyroid hormone deficiency effects on nerve and muscle fibers, pulmonary system and alveolar ventilation. The aim of this study was to evaluate the effect of Levothyroxine therapy on pulmonary function in hypothyroidism patients in Imam Hospital.Materials and methods: This study was performed on 50 patients with hypothyroidism in Imam Hospital, Sari, Iran, 2006-2007. After a detailed clinical history and systemic examination, level of TSH, T4 and ABG test, chest radiography and spirometery was performed in all patients. The spirometery indexes including FVC, FEV1, FEV1/FVC, FEF 25-75, PEF were recorded. All patients treated with Levothyroxine 1.6μg/kg. After that all systemic and clinical examination, and chest radiography and spirometery performed again. Results analyzed by means of SPSS (11) software and paired t test. The p value less than 0.05 was considered to be significant statisticallyResults: 50 female patients, with mean age of 34.98±13.4 years were studied. The mean of TSH, T4 before treatment were 51.44±25.3 mIu/l and 2.8± 0.9 μg/dl and after treatment were 3.64±2.4 mIu/l and 9.80±4.9 μg/dl respectively (P= 0.0001). The ABG parameters were in normal range and there was no statistically significant difference between before and after treatment. Statistical analysis demonstrated significant differences between mean of FVC, FEV1, FEV1/FVC, FEF 25-75, and PEF before and after treatment.Conclusion: Our study demonstrates that treatment of hypothyroidism with Levothyroxine can improves the pulmonary function according to spirometery findings. |
| first_indexed | 2024-04-13T10:13:06Z |
| format | Article |
| id | doaj.art-76268e8ebb2540739302a5cf3eb7a910 |
| institution | Directory Open Access Journal |
| issn | 1735-9260 1735-9279 |
| language | English |
| last_indexed | 2024-04-13T10:13:06Z |
| publishDate | 2008-01-01 |
| publisher | Mazandaran University of Medical Sciences |
| record_format | Article |
| series | Journal of Mazandaran University of Medical Sciences |
| spelling | doaj.art-76268e8ebb2540739302a5cf3eb7a9102022-12-22T02:50:50ZengMazandaran University of Medical SciencesJournal of Mazandaran University of Medical Sciences1735-92601735-92792008-01-01186716Evaluation of levothyroxine effect on pulmonary function inhypothyroidismHamid Reza ZakeriZhila Torabi ZadehAli Sharif PoorZahra KashiOzra Akha(Received 14 Jul, 2008; Accepted 12 Nov, 2008) Abstract Background and purpose: Hypothyroidism is one of the most common diseases in endocrinology Thyroid hormone deficiency effects on nerve and muscle fibers, pulmonary system and alveolar ventilation. The aim of this study was to evaluate the effect of Levothyroxine therapy on pulmonary function in hypothyroidism patients in Imam Hospital.Materials and methods: This study was performed on 50 patients with hypothyroidism in Imam Hospital, Sari, Iran, 2006-2007. After a detailed clinical history and systemic examination, level of TSH, T4 and ABG test, chest radiography and spirometery was performed in all patients. The spirometery indexes including FVC, FEV1, FEV1/FVC, FEF 25-75, PEF were recorded. All patients treated with Levothyroxine 1.6μg/kg. After that all systemic and clinical examination, and chest radiography and spirometery performed again. Results analyzed by means of SPSS (11) software and paired t test. The p value less than 0.05 was considered to be significant statisticallyResults: 50 female patients, with mean age of 34.98±13.4 years were studied. The mean of TSH, T4 before treatment were 51.44±25.3 mIu/l and 2.8± 0.9 μg/dl and after treatment were 3.64±2.4 mIu/l and 9.80±4.9 μg/dl respectively (P= 0.0001). The ABG parameters were in normal range and there was no statistically significant difference between before and after treatment. Statistical analysis demonstrated significant differences between mean of FVC, FEV1, FEV1/FVC, FEF 25-75, and PEF before and after treatment.Conclusion: Our study demonstrates that treatment of hypothyroidism with Levothyroxine can improves the pulmonary function according to spirometery findings.http://www.mazums.ac.ir/index.php?digital_library&do=absview&lang=persian&sid=682Hypothyroidismpulmonary functionlevothyroxinespirometery |
| spellingShingle | Hamid Reza Zakeri Zhila Torabi Zadeh Ali Sharif Poor Zahra Kashi Ozra Akha Evaluation of levothyroxine effect on pulmonary function inhypothyroidism Journal of Mazandaran University of Medical Sciences Hypothyroidism pulmonary function levothyroxine spirometery |
| title | Evaluation of levothyroxine effect on pulmonary function inhypothyroidism |
| title_full | Evaluation of levothyroxine effect on pulmonary function inhypothyroidism |
| title_fullStr | Evaluation of levothyroxine effect on pulmonary function inhypothyroidism |
| title_full_unstemmed | Evaluation of levothyroxine effect on pulmonary function inhypothyroidism |
| title_short | Evaluation of levothyroxine effect on pulmonary function inhypothyroidism |
| title_sort | evaluation of levothyroxine effect on pulmonary function inhypothyroidism |
| topic | Hypothyroidism pulmonary function levothyroxine spirometery |
| url | http://www.mazums.ac.ir/index.php?digital_library&do=absview&lang=persian&sid=682 |
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