Salivary Lactate Dehydrogenase (LDH)- A Novel Technique in Oral Cancer Detection and Diagnosis
Introduction: Oral squamous cell carcinoma (OSCC) is the sixth most common malignancy which is a major cause for cancer morbidity and mortality worldwide. Early diagnosis and intervention improves the overall survival rate. Aim: The current study was done to evaluate the accuracy of salivary LD...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2016-02-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/7223/16243_CE(Ra1)_F(GH)_PF1(EKAK)_PFA(NC_AK)_PF2(PAG).pdf |
| Summary: | Introduction: Oral squamous cell carcinoma (OSCC) is the
sixth most common malignancy which is a major cause for
cancer morbidity and mortality worldwide. Early diagnosis and
intervention improves the overall survival rate.
Aim: The current study was done to evaluate the accuracy of
salivary LDH as a potential biomarker for diagnosis of OSCC
and to correlate the levels of salivary LDH with the histological
differentiation of the tumour.
Materials and Methods: Thirty patients visiting the outpatient
department diagnosed clinically and histologically with OSCC
were selected for the study with a control group of 20 patients.
Unstimulated salivary samples collected from the selected
patients were centrifuged and processed. Readings of enzyme
activity in the salivary samples was established through auto
analysis using International Federation of Clinical Chemistry
(IFCC) method. Levels of the enzyme activity in both the control
and the study group were compared and statistically analysed
using student t-test. The three subgroups were also compared
and statistically analysed.
Results: The results showed a mean value of 497.00 with a SD
of 51.75 among the control group and a mean value of 1225.40
with a SD of 221.79 among the cases with a p-value of 0.0001
which was statistically significant. Furthermore, when the LDH
values for the various grades of OSCC were compared, the
mean values were 1049.07, 1309.50 and 1586.20 respectively,
for well differentiated, moderately differentiated and poorly
differentiated carcinoma.
Conclusion: The p-value thus obtained revealed LDH
values which were significantly higher in patients with OSCC
and furthermore the levels significantly correlated with the
histopathological grade of the tumour. |
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| ISSN: | 2249-782X 0973-709X |