Gene activation regresses atherosclerosis, promotes health, and enhances longevity
<p>Abstract</p> <p>Background</p> <p>Lifestyle factors and pharmacological compounds activate genetic mechanisms that influence the development of atherosclerotic and other diseases. This article reviews studies on natural and pharmacological gene activation that promot...
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| Format: | Article |
| Language: | English |
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BMC
2010-07-01
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| Series: | Lipids in Health and Disease |
| Online Access: | http://www.lipidworld.com/content/9/1/67 |
| _version_ | 1818141426631835648 |
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| author | Luoma Pauli V |
| author_facet | Luoma Pauli V |
| author_sort | Luoma Pauli V |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Lifestyle factors and pharmacological compounds activate genetic mechanisms that influence the development of atherosclerotic and other diseases. This article reviews studies on natural and pharmacological gene activation that promotes health and enhances longevity.</p> <p>Results</p> <p>Living habits including healthy diet and regular physical activity, and pharmacotherapy, upregulate genes encoding enzymes and apolipoprotein and ATP-binding cassette transporters, acting in metabolic processes that promote health and increase survival. Cytochrome P450-enzymes, physiological factors in maintaining cholesterol homeostasis, generate oxysterols for the elimination of surplus cholesterol. Hepatic CTP:phosphocholine cytidylyltransferase-α is an important regulator of plasma HDL-C level. Gene-activators produce plasma lipoprotein profile, high HDL-C, HDL<sub>2</sub>-C and HDL-C/cholesterol ratio, which is typical of low risk of atherosclerotic disease, and also of exceptional longevity together with reduced prevalence of cardiovascular, metabolic and other diseases. High HDL contributes to protection against inflammation, oxidation and thrombosis, and associates with good cognitive function in very old people. Avoiding unhealthy stress and managing it properly promotes health and increases life expectancy.</p> <p>Conclusions</p> <p>Healthy living habits and gene-activating xenobiotics upregulate mechanisms that produce lipoprotein pattern typical of very old people and enhance longevity. Lipoprotein metabolism and large HDL<sub>2 </sub>associate with the process of living a very long life. Major future goals for health promotion are the improving of commitment to both wise lifestyle choices and drug therapy, and further the developing of new and more effective and well tolerated drugs and treatments.</p> |
| first_indexed | 2024-12-11T10:59:42Z |
| format | Article |
| id | doaj.art-7629d415810346a58fa688b99337503c |
| institution | Directory Open Access Journal |
| issn | 1476-511X |
| language | English |
| last_indexed | 2024-12-11T10:59:42Z |
| publishDate | 2010-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj.art-7629d415810346a58fa688b99337503c2022-12-22T01:09:56ZengBMCLipids in Health and Disease1476-511X2010-07-01916710.1186/1476-511X-9-67Gene activation regresses atherosclerosis, promotes health, and enhances longevityLuoma Pauli V<p>Abstract</p> <p>Background</p> <p>Lifestyle factors and pharmacological compounds activate genetic mechanisms that influence the development of atherosclerotic and other diseases. This article reviews studies on natural and pharmacological gene activation that promotes health and enhances longevity.</p> <p>Results</p> <p>Living habits including healthy diet and regular physical activity, and pharmacotherapy, upregulate genes encoding enzymes and apolipoprotein and ATP-binding cassette transporters, acting in metabolic processes that promote health and increase survival. Cytochrome P450-enzymes, physiological factors in maintaining cholesterol homeostasis, generate oxysterols for the elimination of surplus cholesterol. Hepatic CTP:phosphocholine cytidylyltransferase-α is an important regulator of plasma HDL-C level. Gene-activators produce plasma lipoprotein profile, high HDL-C, HDL<sub>2</sub>-C and HDL-C/cholesterol ratio, which is typical of low risk of atherosclerotic disease, and also of exceptional longevity together with reduced prevalence of cardiovascular, metabolic and other diseases. High HDL contributes to protection against inflammation, oxidation and thrombosis, and associates with good cognitive function in very old people. Avoiding unhealthy stress and managing it properly promotes health and increases life expectancy.</p> <p>Conclusions</p> <p>Healthy living habits and gene-activating xenobiotics upregulate mechanisms that produce lipoprotein pattern typical of very old people and enhance longevity. Lipoprotein metabolism and large HDL<sub>2 </sub>associate with the process of living a very long life. Major future goals for health promotion are the improving of commitment to both wise lifestyle choices and drug therapy, and further the developing of new and more effective and well tolerated drugs and treatments.</p>http://www.lipidworld.com/content/9/1/67 |
| spellingShingle | Luoma Pauli V Gene activation regresses atherosclerosis, promotes health, and enhances longevity Lipids in Health and Disease |
| title | Gene activation regresses atherosclerosis, promotes health, and enhances longevity |
| title_full | Gene activation regresses atherosclerosis, promotes health, and enhances longevity |
| title_fullStr | Gene activation regresses atherosclerosis, promotes health, and enhances longevity |
| title_full_unstemmed | Gene activation regresses atherosclerosis, promotes health, and enhances longevity |
| title_short | Gene activation regresses atherosclerosis, promotes health, and enhances longevity |
| title_sort | gene activation regresses atherosclerosis promotes health and enhances longevity |
| url | http://www.lipidworld.com/content/9/1/67 |
| work_keys_str_mv | AT luomapauliv geneactivationregressesatherosclerosispromoteshealthandenhanceslongevity |