Silymarin-Laden PVP-Nanocontainers Prepared Via the Electrospraying Technique for Improved Aqueous Solubility and Dissolution Rate
Abstract The aim of the present research was to develop a silymarin-laden PVP-nanocontainer providing ameliorated aqueous solubility and dissolution of the drug. Several silymarin-laden formulations were formed with varying quantities of PVP and SDS via the solvent evaporation method using the elect...
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| Format: | Article |
| Language: | English |
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Instituto de Tecnologia do Paraná (Tecpar)
2019-11-01
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| Series: | Brazilian Archives of Biology and Technology |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132019000100612&tlng=en |
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| author | Abid Mehmood Yousaf Usman Rashid Malik Yasser Shahzad Talib Hussain Ikram Ullah Khan Fakhar Ud Din Tariq Mahmood Hafiz Muhammad Ahsan Ahmed Shah Syed Muhammad Rouf Akram |
| author_facet | Abid Mehmood Yousaf Usman Rashid Malik Yasser Shahzad Talib Hussain Ikram Ullah Khan Fakhar Ud Din Tariq Mahmood Hafiz Muhammad Ahsan Ahmed Shah Syed Muhammad Rouf Akram |
| author_sort | Abid Mehmood Yousaf |
| collection | DOAJ |
| description | Abstract The aim of the present research was to develop a silymarin-laden PVP-nanocontainer providing ameliorated aqueous solubility and dissolution of the drug. Several silymarin-laden formulations were formed with varying quantities of PVP and SDS via the solvent evaporation method using the electrospraying technique. The influence of the hydrophilic carriers on solubility and dissolution was explored. The solid-state characterization was carried out by particle-size analysis, PXRD, DSC, FTIR and SEM. All of the formulations demonstrated better solubility and dissolution than did silymarin plain powder. Both the SDS and PVP had positive effects on solubility and dissolution of silymarin in the aqueous media. An increased solubility was attained as the drug/PVP ratio was 1/4; however, further increase in PVP did not provide significant improvement. In particular, a nanocontainer formulation prepared with silymarin, PVP and SDS (1/4/0.5, w/w/w) exhibited the best solubility (26432.76 ± 1749.00 μg/mL) and an excellent dissolution (~92 % in 20 min) than did silymarin plain powder. Also, it demonstrated similar dissolution profiles compared to a commercial product; therefore, might be bioequivalent to the commercial product (f 1 = 3 and f 2 = 69). Moreover, cumulative undersize distribution values as represented by X10, X50 and X90 were 201 ± 21.01 nm, 488 ± 36.05 nm and 392 ± 48.10 nm, respectively. The drug existed in the amorphous state in the PVP-nanocontainers with no strong chemical bonding with other excipients. Thus, this formulation might be used for more effective administration of silymarin via the oral route. |
| first_indexed | 2024-04-11T16:43:49Z |
| format | Article |
| id | doaj.art-762abff90f5f43aaa7d599bb3e9991c7 |
| institution | Directory Open Access Journal |
| issn | 1678-4324 |
| language | English |
| last_indexed | 2024-04-11T16:43:49Z |
| publishDate | 2019-11-01 |
| publisher | Instituto de Tecnologia do Paraná (Tecpar) |
| record_format | Article |
| series | Brazilian Archives of Biology and Technology |
| spelling | doaj.art-762abff90f5f43aaa7d599bb3e9991c72022-12-22T04:13:37ZengInstituto de Tecnologia do Paraná (Tecpar)Brazilian Archives of Biology and Technology1678-43242019-11-016210.1590/1678-4324-2019170754Silymarin-Laden PVP-Nanocontainers Prepared Via the Electrospraying Technique for Improved Aqueous Solubility and Dissolution RateAbid Mehmood Yousafhttps://orcid.org/0000-0001-7866-9474Usman Rashid Malikhttps://orcid.org/0000-0002-8872-9749Yasser Shahzadhttps://orcid.org/0000-0002-0974-2954Talib Hussainhttps://orcid.org/0000-0002-0465-9713Ikram Ullah Khanhttps://orcid.org/0000-0002-8200-0180Fakhar Ud Dinhttps://orcid.org/0000-0001-9537-4897Tariq Mahmoodhttps://orcid.org/0000-0001-7097-5442Hafiz Muhammad Ahsanhttps://orcid.org/0000-0003-0057-5245Ahmed Shah Syedhttps://orcid.org/0000-0001-9616-7937Muhammad Rouf Akramhttps://orcid.org/0000-0001-9899-8988Abstract The aim of the present research was to develop a silymarin-laden PVP-nanocontainer providing ameliorated aqueous solubility and dissolution of the drug. Several silymarin-laden formulations were formed with varying quantities of PVP and SDS via the solvent evaporation method using the electrospraying technique. The influence of the hydrophilic carriers on solubility and dissolution was explored. The solid-state characterization was carried out by particle-size analysis, PXRD, DSC, FTIR and SEM. All of the formulations demonstrated better solubility and dissolution than did silymarin plain powder. Both the SDS and PVP had positive effects on solubility and dissolution of silymarin in the aqueous media. An increased solubility was attained as the drug/PVP ratio was 1/4; however, further increase in PVP did not provide significant improvement. In particular, a nanocontainer formulation prepared with silymarin, PVP and SDS (1/4/0.5, w/w/w) exhibited the best solubility (26432.76 ± 1749.00 μg/mL) and an excellent dissolution (~92 % in 20 min) than did silymarin plain powder. Also, it demonstrated similar dissolution profiles compared to a commercial product; therefore, might be bioequivalent to the commercial product (f 1 = 3 and f 2 = 69). Moreover, cumulative undersize distribution values as represented by X10, X50 and X90 were 201 ± 21.01 nm, 488 ± 36.05 nm and 392 ± 48.10 nm, respectively. The drug existed in the amorphous state in the PVP-nanocontainers with no strong chemical bonding with other excipients. Thus, this formulation might be used for more effective administration of silymarin via the oral route.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132019000100612&tlng=ensilymarinelectrosprayingPVP-nanocontainersaqueous solubilitydissolution |
| spellingShingle | Abid Mehmood Yousaf Usman Rashid Malik Yasser Shahzad Talib Hussain Ikram Ullah Khan Fakhar Ud Din Tariq Mahmood Hafiz Muhammad Ahsan Ahmed Shah Syed Muhammad Rouf Akram Silymarin-Laden PVP-Nanocontainers Prepared Via the Electrospraying Technique for Improved Aqueous Solubility and Dissolution Rate Brazilian Archives of Biology and Technology silymarin electrospraying PVP-nanocontainers aqueous solubility dissolution |
| title | Silymarin-Laden PVP-Nanocontainers Prepared Via the Electrospraying Technique for Improved Aqueous Solubility and Dissolution Rate |
| title_full | Silymarin-Laden PVP-Nanocontainers Prepared Via the Electrospraying Technique for Improved Aqueous Solubility and Dissolution Rate |
| title_fullStr | Silymarin-Laden PVP-Nanocontainers Prepared Via the Electrospraying Technique for Improved Aqueous Solubility and Dissolution Rate |
| title_full_unstemmed | Silymarin-Laden PVP-Nanocontainers Prepared Via the Electrospraying Technique for Improved Aqueous Solubility and Dissolution Rate |
| title_short | Silymarin-Laden PVP-Nanocontainers Prepared Via the Electrospraying Technique for Improved Aqueous Solubility and Dissolution Rate |
| title_sort | silymarin laden pvp nanocontainers prepared via the electrospraying technique for improved aqueous solubility and dissolution rate |
| topic | silymarin electrospraying PVP-nanocontainers aqueous solubility dissolution |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132019000100612&tlng=en |
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