Investigating pleiotropic effects of statins on ischemic heart disease in the UK Biobank using Mendelian randomisation

Investigating pleiotropic effects of statins on ischemic heart disease in the UK Biobank using Mendelian randomisation

We examined whether specifically statins, of the major lipid modifiers (statins, proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors and ezetimibe) have pleiotropic effects on ischemic heart disease (IHD) via testosterone in men or women. As a validation, we similarly assessed whether a...

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Bibliographic Details
Main Authors: CM Schooling, JV Zhao, SL Au Yeung, GM Leung
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-08-01
Series:eLife
Subjects:
statin
cardiovascular
pleiotropy
sex-specific
testosterone
Online Access:https://elifesciences.org/articles/58567

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