Alpha1-adrenergic receptor blockade in the ventral tegmental area attenuates acquisition of cocaine-induced pavlovian associative learning

Alpha1-adrenergic receptor blockade in the ventral tegmental area attenuates acquisition of cocaine-induced pavlovian associative learning

Activity of the alpha1-adrenergic receptor (α1-AR) in the ventral tegmental area (VTA) modulates dopaminergic activity, implying its modulatory role in the behavioral functions of the dopamine (DA) system. Indeed, intra-VTA α1-AR blockade attenuates conditioned stimulus dependent behaviors such as d...

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Bibliographic Details
Main Authors: Wojciech B. Solecki, Michał Kielbinski, Joanna Bernacka, Katarzyna Gralec, Adam Klasa, Kamil Pradel, Karolina Rojek-Sito, Ryszard Przewłocki
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
ventral tegmental area (VTA)
phasic dopamine
alpha1-adrenergic receptor
Pavlovian associative learning
salience
Online Access:https://www.frontiersin.org/articles/10.3389/fnbeh.2022.969104/full

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https://www.frontiersin.org/articles/10.3389/fnbeh.2022.969104/full

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