Preoperative versus postoperative misoprostol use for prevention of blood loss during caesarean section in pregnant women at term: a multi-centre randomised controlled trial
Objective Caesarean section is associated with higher blood loss than vaginal delivery. This study was performed to compare the safety and efficacy of preoperative versus postoperative rectal and sublingual misoprostol use for prevention of blood loss in women undergoing elective caesarean delivery....
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2023-11-01
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| Series: | Journal of International Medical Research |
| Online Access: | https://doi.org/10.1177/03000605231213242 |
| _version_ | 1797498059139055616 |
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| author | Leonard Ogbonna Ajah Monique Iheoma Ajah Hyginus Uzo Ezegwui Theophilus Ogochukwu Nwankwo Chukwuemeka Anthony Iyoke Wilson Ndukwe Nwigboji |
| author_facet | Leonard Ogbonna Ajah Monique Iheoma Ajah Hyginus Uzo Ezegwui Theophilus Ogochukwu Nwankwo Chukwuemeka Anthony Iyoke Wilson Ndukwe Nwigboji |
| author_sort | Leonard Ogbonna Ajah |
| collection | DOAJ |
| description | Objective Caesarean section is associated with higher blood loss than vaginal delivery. This study was performed to compare the safety and efficacy of preoperative versus postoperative rectal and sublingual misoprostol use for prevention of blood loss in women undergoing elective caesarean delivery. Methods Eligible patients in Southeast Nigeria were randomly classified into those that received 600 µg of preoperative rectal, postoperative rectal, preoperative sublingual, and postoperative sublingual misoprostol. All patients received 10 units of intravenous oxytocin immediately after delivery. Data were analysed with SPSS Version 23. Results Preoperative sublingual misoprostol use caused the highest postoperative packed cell volume, least change in the packed cell volume, and lowest intraoperative blood loss. Preoperative sublingual and rectal misoprostol use was associated with better haematological indices and maternal outcomes than postoperative use by these routes. However, preoperative sublingual and rectal use caused more maternal side effects than postoperative use by these routes. Conclusion Preoperative sublingual misoprostol was associated with the most favourable haematological indices. Although preoperative sublingual and rectal misoprostol use caused more maternal side effects, these routes were associated with better haematological indices and maternal outcomes than postoperative sublingual and rectal misoprostol use. |
| first_indexed | 2024-03-10T03:28:00Z |
| format | Article |
| id | doaj.art-762e78a9c40f48f38ae9d0ea623f919a |
| institution | Directory Open Access Journal |
| issn | 1473-2300 |
| language | English |
| last_indexed | 2024-03-10T03:28:00Z |
| publishDate | 2023-11-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of International Medical Research |
| spelling | doaj.art-762e78a9c40f48f38ae9d0ea623f919a2023-11-23T12:03:57ZengSAGE PublishingJournal of International Medical Research1473-23002023-11-015110.1177/03000605231213242Preoperative versus postoperative misoprostol use for prevention of blood loss during caesarean section in pregnant women at term: a multi-centre randomised controlled trialLeonard Ogbonna AjahMonique Iheoma AjahHyginus Uzo EzegwuiTheophilus Ogochukwu NwankwoChukwuemeka Anthony IyokeWilson Ndukwe NwigbojiObjective Caesarean section is associated with higher blood loss than vaginal delivery. This study was performed to compare the safety and efficacy of preoperative versus postoperative rectal and sublingual misoprostol use for prevention of blood loss in women undergoing elective caesarean delivery. Methods Eligible patients in Southeast Nigeria were randomly classified into those that received 600 µg of preoperative rectal, postoperative rectal, preoperative sublingual, and postoperative sublingual misoprostol. All patients received 10 units of intravenous oxytocin immediately after delivery. Data were analysed with SPSS Version 23. Results Preoperative sublingual misoprostol use caused the highest postoperative packed cell volume, least change in the packed cell volume, and lowest intraoperative blood loss. Preoperative sublingual and rectal misoprostol use was associated with better haematological indices and maternal outcomes than postoperative use by these routes. However, preoperative sublingual and rectal use caused more maternal side effects than postoperative use by these routes. Conclusion Preoperative sublingual misoprostol was associated with the most favourable haematological indices. Although preoperative sublingual and rectal misoprostol use caused more maternal side effects, these routes were associated with better haematological indices and maternal outcomes than postoperative sublingual and rectal misoprostol use.https://doi.org/10.1177/03000605231213242 |
| spellingShingle | Leonard Ogbonna Ajah Monique Iheoma Ajah Hyginus Uzo Ezegwui Theophilus Ogochukwu Nwankwo Chukwuemeka Anthony Iyoke Wilson Ndukwe Nwigboji Preoperative versus postoperative misoprostol use for prevention of blood loss during caesarean section in pregnant women at term: a multi-centre randomised controlled trial Journal of International Medical Research |
| title | Preoperative versus postoperative misoprostol use for prevention of blood loss during caesarean section in pregnant women at term: a multi-centre randomised controlled trial |
| title_full | Preoperative versus postoperative misoprostol use for prevention of blood loss during caesarean section in pregnant women at term: a multi-centre randomised controlled trial |
| title_fullStr | Preoperative versus postoperative misoprostol use for prevention of blood loss during caesarean section in pregnant women at term: a multi-centre randomised controlled trial |
| title_full_unstemmed | Preoperative versus postoperative misoprostol use for prevention of blood loss during caesarean section in pregnant women at term: a multi-centre randomised controlled trial |
| title_short | Preoperative versus postoperative misoprostol use for prevention of blood loss during caesarean section in pregnant women at term: a multi-centre randomised controlled trial |
| title_sort | preoperative versus postoperative misoprostol use for prevention of blood loss during caesarean section in pregnant women at term a multi centre randomised controlled trial |
| url | https://doi.org/10.1177/03000605231213242 |
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