Extracellular matrix containing nanocomposite bone graft in periodontal regeneration – A randomized controlled clinical and radiographic evaluation
Background: The study aims to evaluate the effect of adding extracellular matrix (ECM) component – natural collagen to nanocrystalline hydroxyapatite (nHA) bone graft in the treatment of intrabony defect in chronic periodontitis patients. Materials and Methods: Forty chronic periodontitis patients h...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2021-01-01
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| Series: | Journal of Indian Society of Periodontology |
| Subjects: | |
| Online Access: | http://www.jisponline.com/article.asp?issn=0972-124X;year=2021;volume=25;issue=4;spage=313;epage=319;aulast=Deshpande |
| _version_ | 1818607818595368960 |
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| author | Abhinav Prakash Deshpande Mala Dixit Baburaj Lashika Vasant Tambe Upendra Prasad |
| author_facet | Abhinav Prakash Deshpande Mala Dixit Baburaj Lashika Vasant Tambe Upendra Prasad |
| author_sort | Abhinav Prakash Deshpande |
| collection | DOAJ |
| description | Background: The study aims to evaluate the effect of adding extracellular matrix (ECM) component – natural collagen to nanocrystalline hydroxyapatite (nHA) bone graft in the treatment of intrabony defect in chronic periodontitis patients. Materials and Methods: Forty chronic periodontitis patients having at least one intrabony defect were treated surgically by open flap debridement and the defect grafted (Group A: 20 sites grafted with nHA with natural collagen and Group B: 20 sites grafted with nHA). Plaque index, gingival index, probing pocket depth (PPD), clinical attachment level (CAL), and radiographic defect depth (RDD) were evaluated. Results: The mean PPD reduced from 7.6 ± 0.88 at baseline to 4.45 ± 0.69 and 2.60 ± 0.6 at 3 and 6 months, respectively, in Group A. In Group B, the mean PPD reduced from 7.5 ± 0.89 at baseline to 4.95 ± 0.60 and 2.65 ± 0.59 at 3 and 6 months, respectively. The mean CAL reduced from 7.75 ± 0.85 at baseline to 5.05 ± 0.76 and 3.6 ± 0.68 at 3 and 6 months, respectively, in Group A. In Group B, the mean CAL reduced from 7.70 ± 0.86 at baseline to 5.8 ± 0.7 and 3.75 ± 0.64 at 3 and 6 months, respectively. The mean RDD reduced from 8.13 ± 0.78 and 8.12 ± 0.83 at baseline to 4.27 ± 0.66 and 3.94 ± 0.5 after 6 months in Groups A and B, respectively. After 3 months, a statistically significant reduction in mean PPD and CAL values was noted in Group A while the results were comparable after 6 months. Conclusion: The effectiveness of nHA composite during initial healing phase (3 months) can be attributed to the presence of ECM-collagen in bone graft matrix. |
| first_indexed | 2024-12-16T14:32:48Z |
| format | Article |
| id | doaj.art-762f8d9e65b84f0b98a1b3d090d7145d |
| institution | Directory Open Access Journal |
| issn | 0972-124X |
| language | English |
| last_indexed | 2024-12-16T14:32:48Z |
| publishDate | 2021-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Indian Society of Periodontology |
| spelling | doaj.art-762f8d9e65b84f0b98a1b3d090d7145d2022-12-21T22:28:11ZengWolters Kluwer Medknow PublicationsJournal of Indian Society of Periodontology0972-124X2021-01-0125431331910.4103/jisp.jisp_440_20Extracellular matrix containing nanocomposite bone graft in periodontal regeneration – A randomized controlled clinical and radiographic evaluationAbhinav Prakash DeshpandeMala Dixit BaburajLashika Vasant TambeUpendra PrasadBackground: The study aims to evaluate the effect of adding extracellular matrix (ECM) component – natural collagen to nanocrystalline hydroxyapatite (nHA) bone graft in the treatment of intrabony defect in chronic periodontitis patients. Materials and Methods: Forty chronic periodontitis patients having at least one intrabony defect were treated surgically by open flap debridement and the defect grafted (Group A: 20 sites grafted with nHA with natural collagen and Group B: 20 sites grafted with nHA). Plaque index, gingival index, probing pocket depth (PPD), clinical attachment level (CAL), and radiographic defect depth (RDD) were evaluated. Results: The mean PPD reduced from 7.6 ± 0.88 at baseline to 4.45 ± 0.69 and 2.60 ± 0.6 at 3 and 6 months, respectively, in Group A. In Group B, the mean PPD reduced from 7.5 ± 0.89 at baseline to 4.95 ± 0.60 and 2.65 ± 0.59 at 3 and 6 months, respectively. The mean CAL reduced from 7.75 ± 0.85 at baseline to 5.05 ± 0.76 and 3.6 ± 0.68 at 3 and 6 months, respectively, in Group A. In Group B, the mean CAL reduced from 7.70 ± 0.86 at baseline to 5.8 ± 0.7 and 3.75 ± 0.64 at 3 and 6 months, respectively. The mean RDD reduced from 8.13 ± 0.78 and 8.12 ± 0.83 at baseline to 4.27 ± 0.66 and 3.94 ± 0.5 after 6 months in Groups A and B, respectively. After 3 months, a statistically significant reduction in mean PPD and CAL values was noted in Group A while the results were comparable after 6 months. Conclusion: The effectiveness of nHA composite during initial healing phase (3 months) can be attributed to the presence of ECM-collagen in bone graft matrix.http://www.jisponline.com/article.asp?issn=0972-124X;year=2021;volume=25;issue=4;spage=313;epage=319;aulast=Deshpandebone graftscollagenextracellular matrixnanocrystalline hydroxyapatiteperiodontal regeneration |
| spellingShingle | Abhinav Prakash Deshpande Mala Dixit Baburaj Lashika Vasant Tambe Upendra Prasad Extracellular matrix containing nanocomposite bone graft in periodontal regeneration – A randomized controlled clinical and radiographic evaluation Journal of Indian Society of Periodontology bone grafts collagen extracellular matrix nanocrystalline hydroxyapatite periodontal regeneration |
| title | Extracellular matrix containing nanocomposite bone graft in periodontal regeneration – A randomized controlled clinical and radiographic evaluation |
| title_full | Extracellular matrix containing nanocomposite bone graft in periodontal regeneration – A randomized controlled clinical and radiographic evaluation |
| title_fullStr | Extracellular matrix containing nanocomposite bone graft in periodontal regeneration – A randomized controlled clinical and radiographic evaluation |
| title_full_unstemmed | Extracellular matrix containing nanocomposite bone graft in periodontal regeneration – A randomized controlled clinical and radiographic evaluation |
| title_short | Extracellular matrix containing nanocomposite bone graft in periodontal regeneration – A randomized controlled clinical and radiographic evaluation |
| title_sort | extracellular matrix containing nanocomposite bone graft in periodontal regeneration a randomized controlled clinical and radiographic evaluation |
| topic | bone grafts collagen extracellular matrix nanocrystalline hydroxyapatite periodontal regeneration |
| url | http://www.jisponline.com/article.asp?issn=0972-124X;year=2021;volume=25;issue=4;spage=313;epage=319;aulast=Deshpande |
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