m6A hypomethylation of DNMT3B regulated by ALKBH5 promotes intervertebral disc degeneration via E4F1 deficiency

m6A hypomethylation of DNMT3B regulated by ALKBH5 promotes intervertebral disc degeneration via E4F1 deficiency

Abstract Background The intervertebral disc (IVD) degeneration is the leading cause of low back pain, which accounts for a main cause of disability. N6‐methyladenosine (m6A) is the most abundant internal modification in eukaryotic messenger RNAs and is involved in various diseases and cellular proce...

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Bibliographic Details
Main Authors:	Gaocai Li, Rongjin Luo, Weifeng Zhang, Shujie He, Bingjin Wang, Huaizhen Liang, Yu Song, Wencan Ke, Yunsong Shi, Xiaobo Feng, Kangcheng Zhao, Xinghuo Wu, Yukun Zhang, Kun Wang, Cao Yang
Format:	Article
Language:	English
Published:	Wiley 2022-03-01
Series:	Clinical and Translational Medicine
Subjects:	ALKBH5 DNMT3B intervertebral disc degeneration m6A nucleus pulposus cell senescence
Online Access:	https://doi.org/10.1002/ctm2.765

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