Computational, spectroscopic, sensor and biological studies of Cu(II) complex of Fluoro substituted Schiff base
Schiff base ligand (FHPB - 2-[N-(fluorophenyl)-4‑hydroxy-4-phenyl] 3-butene), and its copper complex Cu[FHPB]2 were prepared and the structural framework of prepared compounds were characterized by analytical, spectroscopic and DFT calculation techniques. The result suggests that, prepared Cu[FPB]2...
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Elsevier
2024-06-01
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| Series: | Chemical Physics Impact |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667022424001269 |
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| author | Chinnaraj Kanagavalli Manivannan Kalanithi Shunmugasundaram Gurusamy Radhakrishnan Nandini Asha Nagaraj Menaka Megtalin Murugesan Sankarganesh |
| author_facet | Chinnaraj Kanagavalli Manivannan Kalanithi Shunmugasundaram Gurusamy Radhakrishnan Nandini Asha Nagaraj Menaka Megtalin Murugesan Sankarganesh |
| author_sort | Chinnaraj Kanagavalli |
| collection | DOAJ |
| description | Schiff base ligand (FHPB - 2-[N-(fluorophenyl)-4‑hydroxy-4-phenyl] 3-butene), and its copper complex Cu[FHPB]2 were prepared and the structural framework of prepared compounds were characterized by analytical, spectroscopic and DFT calculation techniques. The result suggests that, prepared Cu[FPB]2 complex possesses square planar geometry. Electrochemical studies reveal that Cu[FPB]2 complex is quasi reversible in nature. Sensing ability of prepared ligand with various cations were analyzed by absorption and emission spectral techniques and infer that the ligand FHPB is highly sensitive and selective sensor for the Cu2+ ion as compared to other selected metal ions. Antimicrobial activities of FHPB and Cu[FPB]2 against selected bacterial and fungal strains were checked by Disc Diffusion method. DNA interaction of prepared compounds were analyzed by spectrophotometric and spectrofluorometric techniques. The analysis illustrates that the synthesized compounds interact with calf thymus DNA by the way of an intercalation mode. Moreover, the binding ability of FHPB and Cu[FPB]2 were demonstrated by molecular docking and it evidences the strong binding with CT-DNA double helix. |
| first_indexed | 2024-04-24T16:24:41Z |
| format | Article |
| id | doaj.art-76328cfef8ed43829f7d0bfc6190b158 |
| institution | Directory Open Access Journal |
| issn | 2667-0224 |
| language | English |
| last_indexed | 2024-04-24T16:24:41Z |
| publishDate | 2024-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Chemical Physics Impact |
| spelling | doaj.art-76328cfef8ed43829f7d0bfc6190b1582024-03-31T04:38:09ZengElsevierChemical Physics Impact2667-02242024-06-018100582Computational, spectroscopic, sensor and biological studies of Cu(II) complex of Fluoro substituted Schiff baseChinnaraj Kanagavalli0Manivannan Kalanithi1Shunmugasundaram Gurusamy2Radhakrishnan Nandini Asha3Nagaraj Menaka Megtalin4Murugesan Sankarganesh5PG and Research Centre of Chemistry, Jayaraj Annapackium College for Women (Affiliated to Mother Teresa Women's University, Kodaikanal), Periyakulam, Theni, Tamil Nadu 625601, IndiaPG and Research Centre of Chemistry, Jayaraj Annapackium College for Women (Affiliated to Mother Teresa Women's University, Kodaikanal), Periyakulam, Theni, Tamil Nadu 625601, India; Corresponding authors: PG & Research Department of Chemistry, JayarajAnnapackium College for Women, (Affiliated to Mother Teresa Women's University), Periyakulam, Theni, Tamil Nadu 625601, India.Department of Chemistry, V.O. Chidambaram College, Tuticorin, Tamil Nadu 628 008, IndiaDepartment of Chemistry, Sarah Tucker College (Autonomous), Tirunelveli, Tamil Nadu 627 007, IndiaPG and Research Centre of Chemistry, Jayaraj Annapackium College for Women (Affiliated to Mother Teresa Women's University, Kodaikanal), Periyakulam, Theni, Tamil Nadu 625601, IndiaDepartment of Chemistry, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, Tamil Nadu 602105, India; Corresponding Authors: Department of Chemistry, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai 602105, India.Schiff base ligand (FHPB - 2-[N-(fluorophenyl)-4‑hydroxy-4-phenyl] 3-butene), and its copper complex Cu[FHPB]2 were prepared and the structural framework of prepared compounds were characterized by analytical, spectroscopic and DFT calculation techniques. The result suggests that, prepared Cu[FPB]2 complex possesses square planar geometry. Electrochemical studies reveal that Cu[FPB]2 complex is quasi reversible in nature. Sensing ability of prepared ligand with various cations were analyzed by absorption and emission spectral techniques and infer that the ligand FHPB is highly sensitive and selective sensor for the Cu2+ ion as compared to other selected metal ions. Antimicrobial activities of FHPB and Cu[FPB]2 against selected bacterial and fungal strains were checked by Disc Diffusion method. DNA interaction of prepared compounds were analyzed by spectrophotometric and spectrofluorometric techniques. The analysis illustrates that the synthesized compounds interact with calf thymus DNA by the way of an intercalation mode. Moreover, the binding ability of FHPB and Cu[FPB]2 were demonstrated by molecular docking and it evidences the strong binding with CT-DNA double helix.http://www.sciencedirect.com/science/article/pii/S2667022424001269Fluoro-schiff baseCu(ii) complexDftDNA bindingmolecular docking |
| spellingShingle | Chinnaraj Kanagavalli Manivannan Kalanithi Shunmugasundaram Gurusamy Radhakrishnan Nandini Asha Nagaraj Menaka Megtalin Murugesan Sankarganesh Computational, spectroscopic, sensor and biological studies of Cu(II) complex of Fluoro substituted Schiff base Chemical Physics Impact Fluoro-schiff base Cu(ii) complex Dft DNA binding molecular docking |
| title | Computational, spectroscopic, sensor and biological studies of Cu(II) complex of Fluoro substituted Schiff base |
| title_full | Computational, spectroscopic, sensor and biological studies of Cu(II) complex of Fluoro substituted Schiff base |
| title_fullStr | Computational, spectroscopic, sensor and biological studies of Cu(II) complex of Fluoro substituted Schiff base |
| title_full_unstemmed | Computational, spectroscopic, sensor and biological studies of Cu(II) complex of Fluoro substituted Schiff base |
| title_short | Computational, spectroscopic, sensor and biological studies of Cu(II) complex of Fluoro substituted Schiff base |
| title_sort | computational spectroscopic sensor and biological studies of cu ii complex of fluoro substituted schiff base |
| topic | Fluoro-schiff base Cu(ii) complex Dft DNA binding molecular docking |
| url | http://www.sciencedirect.com/science/article/pii/S2667022424001269 |
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