IMMUNOCHEMICAL STUDY OF RECEPTION OF PLAGUE BACTERIOPHAGE POKROVSKY
Aim. Study of mechanism of reception of plague bacteriophage Pokrovsky to cells of Yersinia pestis using a panel of monoclonal antibodies. Materials and methods. Using a method of competitive inhibition, the ability of monoclonal antibodies against antigenic epitopes of outer membrane of Yersinia ge...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
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Central Research Institute for Epidemiology
2016-08-01
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| Series: | Журнал микробиологии, эпидемиологии и иммунобиологии |
| Subjects: | |
| Online Access: | https://microbiol.elpub.ru/jour/article/view/64 |
| _version_ | 1818081082344472576 |
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| author | A. A. Byvalov L. G. Dudina S. G. Litvinets E. A. Martinson |
| author_facet | A. A. Byvalov L. G. Dudina S. G. Litvinets E. A. Martinson |
| author_sort | A. A. Byvalov |
| collection | DOAJ |
| description | Aim. Study of mechanism of reception of plague bacteriophage Pokrovsky to cells of Yersinia pestis using a panel of monoclonal antibodies. Materials and methods. Using a method of competitive inhibition, the ability of monoclonal antibodies against antigenic epitopes of outer membrane of Yersinia genus bacteria to inhibit adhesion of the studied bacteriophage to cells of Y. pestis EV strain, was evaluated. Results. A key role of structure of carbohydrate nature in reception of Pokrovsky bacteriophage was confirmed. Among 5 lines of monoclonal antibodies against protein epitopes 2 were established to cause significant inactivation of bacteriophage adhesion to bacterial cells. Conclusion. An assumption is proposed regarding participation of a structure of polypeptide nature in reception of Pokrovsky bacteriophage by cells of plague microbe. |
| first_indexed | 2024-12-10T19:00:33Z |
| format | Article |
| id | doaj.art-76342c1ad01e41f19d480da86fda50ff |
| institution | Directory Open Access Journal |
| issn | 0372-9311 2686-7613 |
| language | Russian |
| last_indexed | 2024-12-10T19:00:33Z |
| publishDate | 2016-08-01 |
| publisher | Central Research Institute for Epidemiology |
| record_format | Article |
| series | Журнал микробиологии, эпидемиологии и иммунобиологии |
| spelling | doaj.art-76342c1ad01e41f19d480da86fda50ff2022-12-22T01:37:01ZrusCentral Research Institute for EpidemiologyЖурнал микробиологии, эпидемиологии и иммунобиологии0372-93112686-76132016-08-0104162110.36233/0372-9311-2016-4-16-2164IMMUNOCHEMICAL STUDY OF RECEPTION OF PLAGUE BACTERIOPHAGE POKROVSKYA. A. Byvalov0L. G. Dudina1S. G. Litvinets2E. A. Martinson3Vyatsky State University, institute of PhysiologyVyatsky State UniversityVyatsky State UniversityVyatsky State UniversityAim. Study of mechanism of reception of plague bacteriophage Pokrovsky to cells of Yersinia pestis using a panel of monoclonal antibodies. Materials and methods. Using a method of competitive inhibition, the ability of monoclonal antibodies against antigenic epitopes of outer membrane of Yersinia genus bacteria to inhibit adhesion of the studied bacteriophage to cells of Y. pestis EV strain, was evaluated. Results. A key role of structure of carbohydrate nature in reception of Pokrovsky bacteriophage was confirmed. Among 5 lines of monoclonal antibodies against protein epitopes 2 were established to cause significant inactivation of bacteriophage adhesion to bacterial cells. Conclusion. An assumption is proposed regarding participation of a structure of polypeptide nature in reception of Pokrovsky bacteriophage by cells of plague microbe.https://microbiol.elpub.ru/jour/article/view/64bacteriophageyersinia pestismonoclonal antibodiesadhesion |
| spellingShingle | A. A. Byvalov L. G. Dudina S. G. Litvinets E. A. Martinson IMMUNOCHEMICAL STUDY OF RECEPTION OF PLAGUE BACTERIOPHAGE POKROVSKY Журнал микробиологии, эпидемиологии и иммунобиологии bacteriophage yersinia pestis monoclonal antibodies adhesion |
| title | IMMUNOCHEMICAL STUDY OF RECEPTION OF PLAGUE BACTERIOPHAGE POKROVSKY |
| title_full | IMMUNOCHEMICAL STUDY OF RECEPTION OF PLAGUE BACTERIOPHAGE POKROVSKY |
| title_fullStr | IMMUNOCHEMICAL STUDY OF RECEPTION OF PLAGUE BACTERIOPHAGE POKROVSKY |
| title_full_unstemmed | IMMUNOCHEMICAL STUDY OF RECEPTION OF PLAGUE BACTERIOPHAGE POKROVSKY |
| title_short | IMMUNOCHEMICAL STUDY OF RECEPTION OF PLAGUE BACTERIOPHAGE POKROVSKY |
| title_sort | immunochemical study of reception of plague bacteriophage pokrovsky |
| topic | bacteriophage yersinia pestis monoclonal antibodies adhesion |
| url | https://microbiol.elpub.ru/jour/article/view/64 |
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